Abstract
Temporary remission of scleroderma during the successful treatment of an associated malignant lymphoma by chemotherapy is reported in a patient with systemic sclerosis and mixed connective tissue disease. There is a well established relation between malignant disease and polymyositis/dermatomyositis but no overall association with systemic sclerosis or mixed connective tissue disease. Reports of the coexistence of malignancy and systemic sclerosis, however, emphasise a close temporal relation in their occurrence. A review of published work has identified several postulated mechanisms for this relation which may explain the response to chemotherapy.
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Selected References
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- Alarcón-Segovia D., Ruíz-Arguelles A. Suppressor cell loss and dysfunction in mixed connective tissue disease. Arthritis Rheum. 1980 Mar;23(3):314–318. doi: 10.1002/art.1780230308. [DOI] [PubMed] [Google Scholar]
- Bennett R. M., O'Connell D. J. Mixed connective tisssue disease: a clinicopathologic study of 20 cases. Semin Arthritis Rheum. 1980 Aug;10(1):25–51. doi: 10.1016/0049-0172(80)90013-x. [DOI] [PubMed] [Google Scholar]
- Black C. M. Systemic sclerosis: is there a treatment yet? Ann Rheum Dis. 1990 Sep;49(9):735–737. doi: 10.1136/ard.49.9.735. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Black K. A., Zilko P. J., Dawkins R. L., Armstrong B. K., Mastaglia G. L. Cancer in connective tissue disease. Arthritis Rheum. 1982 Sep;25(9):1130–1133. doi: 10.1002/art.1780250916. [DOI] [PubMed] [Google Scholar]
- Duncan S. C., Winkelmann R. K. Cancer and scleroderma. Arch Dermatol. 1979 Aug;115(8):950–955. [PubMed] [Google Scholar]
- Forbes A. M., Woodrow J. C., Verbov J. L., Graham R. M. Carcinoma of breast and scleroderma: four further cases and a literature review. Br J Rheumatol. 1989 Feb;28(1):65–69. doi: 10.1093/rheumatology/28.1.65. [DOI] [PubMed] [Google Scholar]
- Lee P., Alderdice C., Wilkinson S., Keystone E. C., Urowitz M. B., Gladman D. D. Malignancy in progressive systemic sclerosis--association with breast carcinoma. J Rheumatol. 1983 Aug;10(4):665–666. [PubMed] [Google Scholar]
- Mattingly P. C., Mowat A. G. Rapidly progressive scleroderma associated with carcinoma of the oesophagus. Ann Rheum Dis. 1979 Apr;38(2):177–178. doi: 10.1136/ard.38.2.177. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McLeish K. R., Smith M. R., Gohara A. F. Non-Hodgkin's lymphoma and membranous nephropathy in mixed connective tissue disease. Am J Med Sci. 1985 Oct;290(4):152–154. doi: 10.1097/00000441-198510000-00003. [DOI] [PubMed] [Google Scholar]
- Peters-Golden M., Wise R. A., Hochberg M., Stevens M. B., Wigley F. M. Incidence of lung cancer in systemic sclerosis. J Rheumatol. 1985 Dec;12(6):1136–1139. [PubMed] [Google Scholar]
- Roumm A. D., Medsger T. A., Jr Cancer and systemic sclerosis. An epidemiologic study. Arthritis Rheum. 1985 Dec;28(12):1336–1340. doi: 10.1002/art.1780281204. [DOI] [PubMed] [Google Scholar]
