Abstract
Although systemic lupus erythematosus (SLE) has traditionally been considered a disease of women, men may also be affected. Thirty of 261 patients (12%) with SLE seen in this hospital were men. Arthritis was less common as a first symptom in the men, although this group of patients had discoid lesions and serositis more often than the women. During the follow up a lower incidence of arthritis and malar rash and a higher incidence of other skin complications including discoid lesions and subcutaneous lupus erythematosus was found in the men. The incidence of nephropathy, neurological disease, thrombocytopenia, vasculitis, and serositis, was similar in the two groups. No significant immunological differences were found between men and women. These features indicate that several gender associated clinical differences may be present in patients with SLE.
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- Blum A., Rubinow A., Galun E. Predominance of renal involvement in male patients with systemic lupus erythematosus. Clin Exp Rheumatol. 1991 Mar-Apr;9(2):206–207. [PubMed] [Google Scholar]
- Cervera R., Font J., López-Soto A., Casals F., Pallarés L., Bové A., Ingelmo M., Urbano-Márquez A. Isotype distribution of anticardiolipin antibodies in systemic lupus erythematosus: prospective analysis of a series of 100 patients. Ann Rheum Dis. 1990 Feb;49(2):109–113. doi: 10.1136/ard.49.2.109. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Exner T., Rickard K. A., Kronenberg H. Studies on phospholipids in the action of a lupus coagulation inhibitor. Pathology. 1975 Oct;7(4):319–328. doi: 10.3109/00313027509081688. [DOI] [PubMed] [Google Scholar]
- Font J., Pallarés L., Cervera R., López-Soto A., Navarro M., Bosch X., Ingelmo M. Systemic lupus erythematosus in the elderly: clinical and immunological characteristics. Ann Rheum Dis. 1991 Oct;50(10):702–705. doi: 10.1136/ard.50.10.702. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gharavi A. E., Harris E. N., Asherson R. A., Hughes G. R. Anticardiolipin antibodies: isotype distribution and phospholipid specificity. Ann Rheum Dis. 1987 Jan;46(1):1–6. doi: 10.1136/ard.46.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hochberg M. C., Boyd R. E., Ahearn J. M., Arnett F. C., Bias W. B., Provost T. T., Stevens M. B. Systemic lupus erythematosus: a review of clinico-laboratory features and immunogenetic markers in 150 patients with emphasis on demographic subsets. Medicine (Baltimore) 1985 Sep;64(5):285–295. [PubMed] [Google Scholar]
- Inman R. D., Jovanovic L., Markenson J. A., Longcope C., Dawood M. Y., Lockshin M. D. Systemic lupus erythematosus in men. Genetic and endocrine features. Arch Intern Med. 1982 Oct;142(10):1813–1815. [PubMed] [Google Scholar]
- Kaufman L. D., Gomez-Reino J. J., Heinicke M. H., Gorevic P. D. Male lupus: retrospective analysis of the clinical and laboratory features of 52 patients, with a review of the literature. Semin Arthritis Rheum. 1989 Feb;18(3):189–197. doi: 10.1016/0049-0172(89)90061-9. [DOI] [PubMed] [Google Scholar]
- Lahita R. G., Bradlow H. L., Ginzler E., Pang S., New M. Low plasma androgens in women with systemic lupus erythematosus. Arthritis Rheum. 1987 Mar;30(3):241–248. doi: 10.1002/art.1780300301. [DOI] [PubMed] [Google Scholar]
- Lahita R. G. Sex steroids and the rheumatic diseases. Arthritis Rheum. 1985 Feb;28(2):121–126. doi: 10.1002/art.1780280202. [DOI] [PubMed] [Google Scholar]
- Miller M. H., Urowitz M. B., Gladman D. D., Killinger D. W. Systemic lupus erythematosus in males. Medicine (Baltimore) 1983 Sep;62(5):327–334. doi: 10.1097/00005792-198309000-00005. [DOI] [PubMed] [Google Scholar]
- Schaller J. Lupus in childhood. Clin Rheum Dis. 1982 Apr;8(1):219–228. [PubMed] [Google Scholar]
- Steinberg A. D., Melez K. A., Raveche E. S., Reeves J. P., Boegel W. A., Smathers P. A., Taurog J. D., Weinlein L., Duvic M. Approach to the study of the role of sex hormones in autoimmunity. Arthritis Rheum. 1979 Nov;22(11):1170–1176. doi: 10.1002/art.1780221103. [DOI] [PubMed] [Google Scholar]
- Sthoeger Z. M., Geltner D., Rider A., Bentwich Z. Systemic lupus erythematosus in 49 Israeli males: a retrospective study. Clin Exp Rheumatol. 1987 Jul-Sep;5(3):233–240. [PubMed] [Google Scholar]
- Tan E. M., Cohen A. S., Fries J. F., Masi A. T., McShane D. J., Rothfield N. F., Schaller J. G., Talal N., Winchester R. J. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982 Nov;25(11):1271–1277. doi: 10.1002/art.1780251101. [DOI] [PubMed] [Google Scholar]
- Ward M. M., Studenski S. Systemic lupus erythematosus in men: a multivariate analysis of gender differences in clinical manifestations. J Rheumatol. 1990 Feb;17(2):220–224. [PubMed] [Google Scholar]