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. 1992 Sep;51(9):1085–1087. doi: 10.1136/ard.51.9.1085

Systemic lupus erythematosus induced by isoniazid.

M Salazar-Páramo 1, R L Rubin 1, I García-De La Torre 1
PMCID: PMC1004845  PMID: 1417144

Abstract

The case is described of a 73 year old man who presented with a lupus-like syndrome related to treatment with isoniazid and had IgG antinuclear antibodies against the nucleo-histone complex (H2A-H2B)-DNA. After a short course of treatment with prednisone and discontinuation of isoniazid the patient's lupus symptoms resolved and a gradual decrease in antibodies to (H2A-H2B)-DNA occurred. This case suggests that isoniazid is capable of inducing an autoantibody specificity associated with drug related lupus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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