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. 1992 Dec;51(12):1330–1331. doi: 10.1136/ard.51.12.1330

Methotrexate treatment of rheumatoid arthritis: is a fortnightly maintenance schedule enough?

M Tishler 1, D Caspi 1, M Yaron 1
PMCID: PMC1004930  PMID: 1485816

Abstract

In 15 patients with rheumatoid arthritis who were in clinical remission the weekly regimen of methotrexate treatment was changed to fortnightly without a change in dose. A total of 13 patients completed a 12 month trial. No change in clinical or laboratory parameters occurred. There was no change in the use of analgesics or non-steroidal anti-inflammatory drugs and the patients remained in remission. Two patients had to be withdrawn after two and four months respectively because of a flare in disease activity. It is suggested that in most patients with rheumatoid arthritis who are treated with methotrexate and whose disease activity is stable a fortnightly regimen can be permitted without affecting drug efficacy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alarcón G. S., Tracy I. C., Blackburn W. D., Jr Methotrexate in rheumatoid arthritis. Toxic effects as the major factor in limiting long-term treatment. Arthritis Rheum. 1989 Jun;32(6):671–676. doi: 10.1002/anr.1780320603. [DOI] [PubMed] [Google Scholar]
  2. Brick J. E., Moreland L. W., Al-Kawas F., Chang W. W., Layne R. D., DiBartolomeo A. G. Prospective analysis of liver biopsies before and after methotrexate therapy in rheumatoid patients. Semin Arthritis Rheum. 1989 Aug;19(1):31–44. doi: 10.1016/0049-0172(89)90085-1. [DOI] [PubMed] [Google Scholar]
  3. Dahl M. G., Gregory M. M., Scheuer P. J. Methotrexate hepatotoxicity in psoriasis--comparison of different dose regimens. Br Med J. 1972 Mar 11;1(5801):654–656. doi: 10.1136/bmj.1.5801.654. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Kremer J. M., Lee J. K. A long-term prospective study of the use of methotrexate in rheumatoid arthritis. Update after a mean of fifty-three months. Arthritis Rheum. 1988 May;31(5):577–584. doi: 10.1002/art.1780310501. [DOI] [PubMed] [Google Scholar]
  5. Kremer J. M., Lee R. G., Tolman K. G. Liver histology in rheumatoid arthritis patients receiving long-term methotrexate therapy. A prospective study with baseline and sequential biopsy samples. Arthritis Rheum. 1989 Feb;32(2):121–127. doi: 10.1002/anr.1780320202. [DOI] [PubMed] [Google Scholar]
  6. Kremer J. M., Rynes R. I., Bartholomew L. E. Severe flare of rheumatoid arthritis after discontinuation of long-term methotrexate therapy. Double-blind study. Am J Med. 1987 Apr;82(4):781–786. doi: 10.1016/0002-9343(87)90015-5. [DOI] [PubMed] [Google Scholar]
  7. Mielants H., Veys E. M., Van der Straeten C., Ackerman C., Goemaere S. The efficacy and toxicity of a constant low dose of methotrexate as a treatment for intractable rheumatoid arthritis: an open prospective study. J Rheumatol. 1991 Jul;18(7):978–983. [PubMed] [Google Scholar]
  8. Tishler M., Caspi D., Rosenbach T. O., Fishel B., Wigler I., Segal R., Gazit E., Yaron M. Methotrexate in rheumatoid arthritis: a prospective study in Israeli patients with immunogenetic correlations. Ann Rheum Dis. 1988 Aug;47(8):654–659. doi: 10.1136/ard.47.8.654. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Weinblatt M. E., Trentham D. E., Fraser P. A., Holdsworth D. E., Falchuk K. R., Weissman B. N., Coblyn J. S. Long-term prospective trial of low-dose methotrexate in rheumatoid arthritis. Arthritis Rheum. 1988 Feb;31(2):167–175. doi: 10.1002/art.1780310203. [DOI] [PubMed] [Google Scholar]

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