Skip to main content
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1993 Jan;52(1):67–73. doi: 10.1136/ard.52.1.67

Iron in joint inflammation.

A J Dabbagh 1, C W Trenam 1, C J Morris 1, D R Blake 1
PMCID: PMC1004961  PMID: 8427520

Full text

PDF
67

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahmadzadeh N., Shingu M., Nobunaga M. Iron-binding proteins and free iron in synovial fluids of rheumatoid arthritis patients. Clin Rheumatol. 1989 Sep;8(3):345–351. doi: 10.1007/BF02030347. [DOI] [PubMed] [Google Scholar]
  2. Andrews F. J., Morris C. J., Kondratowicz G., Blake D. R. Effect of iron chelation on inflammatory joint disease. Ann Rheum Dis. 1987 Apr;46(4):327–333. doi: 10.1136/ard.46.4.327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Andus T., Geiger T., Hirano T., Kishimoto T., Heinrich P. C. Action of recombinant human interleukin 6, interleukin 1 beta and tumor necrosis factor alpha on the mRNA induction of acute-phase proteins. Eur J Immunol. 1988 May;18(5):739–746. doi: 10.1002/eji.1830180513. [DOI] [PubMed] [Google Scholar]
  4. Atmaca L. S., Arcasoy A., Cavdar A. O., Ozmert E. Levels of zinc in plasma, erythrocytes, and hair, and levels of serum copper in patients with retinitis pigmentosa in Turkey. Br J Ophthalmol. 1989 Jan;73(1):29–31. doi: 10.1136/bjo.73.1.29. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. BALL J., CHAPMAN J. A., MUIRDEN K. D. THE UPTAKE OF IRON IN RABBIT SYNOVIAL TISSUE FOLLOWING INTRA-ARTICULAR INJECTION OF IRON DEXTRAN. A LIGHT AND ELECTRON MICROSCOPE STUDY. J Cell Biol. 1964 Aug;22:351–364. doi: 10.1083/jcb.22.2.351. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ballart I. J., Estevez M. E., Sen L., Diez R. A., Giuntoli J., de Miani S. A., Peñalver J. Progressive dysfunction of monocytes associated with iron overload and age in patients with thalassemia major. Blood. 1986 Jan;67(1):105–109. [PubMed] [Google Scholar]
  7. Becroft D. M., Dix M. R., Farmer K. Intramuscular iron-dextran and susceptibility of neonates to bacterial infections. In vitro studies. Arch Dis Child. 1977 Oct;52(10):778–781. doi: 10.1136/adc.52.10.778. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Bennett R. M., Williams E. D., Lewis S. M., Holt P. J. Synovial iron deposition in rheumatoid arthritis. Arthritis Rheum. 1973 May-Jun;16(3):298–304. doi: 10.1002/art.1780160303. [DOI] [PubMed] [Google Scholar]
  9. Bentley D. P., Williams P. Serum ferritin concentration as an index of storage iron in rheumatoid arthritis. J Clin Pathol. 1974 Oct;27(10):786–788. doi: 10.1136/jcp.27.10.786. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Biemond P., van Eijk H. G., Swaak A. J., Koster J. F. Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases. J Clin Invest. 1984 Jun;73(6):1576–1579. doi: 10.1172/JCI111364. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Blake D. R., Bacon P. A., Eastham E. J., Brigham K. Synovial fluid ferritin in rheumatoid arthritis. Br Med J. 1980 Sep 13;281(6242):715–716. doi: 10.1136/bmj.281.6242.715. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Blake D. R., Bacon P. A. Synovial fluid ferritin in rheumatoid arthritis: an index or cause of inflammation? Br Med J (Clin Res Ed) 1981 Jan 17;282(6259):189–189. doi: 10.1136/bmj.282.6259.189. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Blake D. R., Gallagher P. J., Potter A. R., Bell M. J., Bacon P. A. The effect of synovial iron on the progression of rheumatoid disease. A histologic assessment of patients with early rheumatoid synovitis. Arthritis Rheum. 1984 May;27(5):495–501. doi: 10.1002/art.1780270503. [DOI] [PubMed] [Google Scholar]
  14. Blake D. R., Hall N. D., Bacon P. A., Dieppe P. A., Halliwell B., Gutteridge J. M. The importance of iron in rheumatoid disease. Lancet. 1981 Nov 21;2(8256):1142–1144. doi: 10.1016/s0140-6736(81)90590-0. [DOI] [PubMed] [Google Scholar]
  15. Blake D. R., Lunec J., Ahern M., Ring E. F., Bradfield J., Gutteridge J. M. Effect of intravenous iron dextran on rheumatoid synovitis. Ann Rheum Dis. 1985 Mar;44(3):183–188. doi: 10.1136/ard.44.3.183. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Blake D., Bacon P. A. Iron and rheumatoid disease. Lancet. 1982 Mar 13;1(8272):623–623. doi: 10.1016/s0140-6736(82)91779-2. [DOI] [PubMed] [Google Scholar]
  17. Brailsford S., Lunec J., Winyard P., Blake D. R. A possible role for ferritin during inflammation. Free Radic Res Commun. 1985;1(2):101–109. doi: 10.3109/10715768509056542. [DOI] [PubMed] [Google Scholar]
  18. Brock J. H., Alvarez-Hernandez X. Modulation of macrophage iron metabolism by tumour necrosis factor and interleukin 1. FEMS Microbiol Immunol. 1989 Apr;1(5):309–309. doi: 10.1111/j.1574-6968.1989.tb02403.x. [DOI] [PubMed] [Google Scholar]
  19. Brock J. H., Esparza I. Failure of reticulocytes to take up iron from lactoferrin saturated by various methods. Br J Haematol. 1979 Jul;42(3):481–483. doi: 10.1111/j.1365-2141.1979.tb01156.x. [DOI] [PubMed] [Google Scholar]
  20. Brock J. H., Rankin M. C. Transferrin binding and iron uptake by mouse lymph node cells during transformation in response to concanavalin A. Immunology. 1981 Jun;43(2):393–398. [PMC free article] [PubMed] [Google Scholar]
  21. Bryan C. F., Leech S. H., Bozelka B. The immunoregulatory nature of iron. II. Lymphocyte surface marker expression. J Leukoc Biol. 1986 Nov;40(5):589–600. doi: 10.1002/jlb.40.5.589. [DOI] [PubMed] [Google Scholar]
  22. Cartwright G. E., Lee G. R. The anaemia of chronic disorders. Br J Haematol. 1971 Aug;21(2):147–152. doi: 10.1111/j.1365-2141.1971.tb03424.x. [DOI] [PubMed] [Google Scholar]
  23. Dabbagh A. J., Blake D. R., Morris C. J. Effect of iron complexes on adjuvant arthritis in rats. Ann Rheum Dis. 1992 Apr;51(4):516–521. doi: 10.1136/ard.51.4.516. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Darlington G. J., Wilson D. R., Lachman L. B. Monocyte-conditioned medium, interleukin-1, and tumor necrosis factor stimulate the acute phase response in human hepatoma cells in vitro. J Cell Biol. 1986 Sep;103(3):787–793. doi: 10.1083/jcb.103.3.787. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Deiss A. Iron metabolism in reticuloendothelial cells. Semin Hematol. 1983 Apr;20(2):81–90. [PubMed] [Google Scholar]
  26. Fillet G., Beguin Y., Baldelli L. Model of reticuloendothelial iron metabolism in humans: abnormal behavior in idiopathic hemochromatosis and in inflammation. Blood. 1989 Aug 1;74(2):844–851. [PubMed] [Google Scholar]
  27. Fillet G., Cook J. D., Finch C. A. Storage iron kinetics. VII. A biologic model for reticuloendothelial iron transport. J Clin Invest. 1974 Jun;53(6):1527–1533. doi: 10.1172/JCI107703. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Flament J., Goldman M., Waterlot Y., Dupont E., Wybran J., Vanherweghem J. L. Impairment of phagocyte oxidative metabolism in hemodialyzed patients with iron overload. Clin Nephrol. 1986 May;25(5):227–230. [PubMed] [Google Scholar]
  29. Fondu P. Les rôles du fer dans la défense contre les infections, et plus particulièrement l'importance des anomalies de la phagocytose au cours des états de surcharge en fer. Bull Mem Acad R Med Belg. 1989;144(3-4):223–231. [PubMed] [Google Scholar]
  30. Good M. F., Chapman D. E., Powell L. W., Halliday J. W. The effect of iron (Fe3+) on the cloning efficiency of human memory T4+ lymphocytes. Clin Exp Immunol. 1986 Nov;66(2):340–347. [PMC free article] [PubMed] [Google Scholar]
  31. Gutteridge J. M., Rowley D. A., Halliwell B. Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts. Detection of 'free' iron in biological systems by using bleomycin-dependent degradation of DNA. Biochem J. 1981 Oct 1;199(1):263–265. doi: 10.1042/bj1990263. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Hansen T. M., Hansen N. E., Birgens H. S., Hølund B., Lorenzen I. Serum ferritin and the assessment of iron deficiency in rheumatoid arthritis. Scand J Rheumatol. 1983;12(4):353–359. doi: 10.3109/03009748309099740. [DOI] [PubMed] [Google Scholar]
  33. Hansen T. M., Hansen N. E. Serum ferritin as indicator of iron responsive anaemia in patients with rheumatoid arthritis. Ann Rheum Dis. 1986 Jul;45(7):596–602. doi: 10.1136/ard.45.7.596. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Hewitt S. D., Hider R. C., Sarpong P., Morris C. J., Blake D. R. Investigation of the anti-inflammatory properties of hydroxypyridinones. Ann Rheum Dis. 1989 May;48(5):382–388. doi: 10.1136/ard.48.5.382. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Hoepelman I. M., Jaarsma E. Y., Verhoef J., Marx J. J. Effect of iron on polymorphonuclear granulocyte phagocytic capacity: role of oxidation state and effect of ascorbic acid. Br J Haematol. 1988 Dec;70(4):495–500. doi: 10.1111/j.1365-2141.1988.tb02523.x. [DOI] [PubMed] [Google Scholar]
  36. Houssiau F. A., Devogelaer J. P., Van Damme J., de Deuxchaisnes C. N., Van Snick J. Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum. 1988 Jun;31(6):784–788. doi: 10.1002/art.1780310614. [DOI] [PubMed] [Google Scholar]
  37. Kay J. E., Benzie C. R. The role of the transferrin receptor in lymphocyte activation. Immunol Lett. 1986 Jan;12(1):55–58. doi: 10.1016/0165-2478(86)90081-7. [DOI] [PubMed] [Google Scholar]
  38. Keown P., Descamps-Latscha B. In vitro suppression of cell-mediated immunity by ferroproteins and ferric salts. Cell Immunol. 1983 Sep;80(2):257–266. doi: 10.1016/0008-8749(83)90114-4. [DOI] [PubMed] [Google Scholar]
  39. Keown P., Descamps B. Suppression de la réaction lymphocytaire mixte par des globules rouges autologues et leurs constituants : une hypothèse nouvelle sur l'effet apparement tolérogène des transfusions sanguines en transplantation. C R Acad Sci Hebd Seances Acad Sci D. 1978 Oct 2;287(7):749–752. [PubMed] [Google Scholar]
  40. Konijn A. M., Hershko C. Ferritin synthesis in inflammation. I. Pathogenesis of impaired iron release. Br J Haematol. 1977 Sep;37(1):7–16. [PubMed] [Google Scholar]
  41. Lin J. J., Daniels-McQueen S., Patino M. M., Gaffield L., Walden W. E., Thach R. E. Derepression of ferritin messenger RNA translation by hemin in vitro. Science. 1990 Jan 5;247(4938):74–77. doi: 10.1126/science.2294594. [DOI] [PubMed] [Google Scholar]
  42. Lloyd K. N., Williams P. Reactions to total dose infusion of iron dextran in rheumatoid arthritis. Br Med J. 1970 May 9;2(5705):323–325. doi: 10.1136/bmj.2.5705.323. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Morris C. J., Blake D. R., Hewitt S. D., Lunec J. Macrophage ferritin and iron deposition in the rat air pouch model of inflammatory synovitis. Ann Rheum Dis. 1987 Apr;46(4):334–338. doi: 10.1136/ard.46.4.334. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Morris C. J., Blake D. R., Wainwright A. C., Steven M. M. Relationship between iron deposits and tissue damage in the synovium: an ultrastructural study. Ann Rheum Dis. 1986 Jan;45(1):21–26. doi: 10.1136/ard.45.1.21. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Morris C. J., Wainwright A. C., Steven M. M., Blake D. R. The nature of iron deposits in haemophilic synovitis. An immunohistochemical, ultrastructural and X-ray microanalytical study. Virchows Arch A Pathol Anat Histopathol. 1984;404(1):75–85. doi: 10.1007/BF00704252. [DOI] [PubMed] [Google Scholar]
  46. Muirden K. D. Ferritin in synovial cells in patients with rheumatoid arthritis. Ann Rheum Dis. 1966 Sep;25(5):387–401. doi: 10.1136/ard.25.5.387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Muirden K. D., Fraser J. R., Clarris B. Ferritin formation by synovial cells exposed to haemoglobin in vitro. Ann Rheum Dis. 1967 May;26(3):251–259. doi: 10.1136/ard.26.3.251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Muirden K. D., Senator G. B. Iron in the synovial membrane in rheumatoid arthritis and other joint diseases. Ann Rheum Dis. 1968 Jan;27(1):38–48. doi: 10.1136/ard.27.1.38. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Muirden K. D. The anaemia of rheumatoid arthritis: the significance of iron deposits in the synovial membrane. Australas Ann Med. 1970 May;19(2):97–104. doi: 10.1111/imj.1970.19.2.97. [DOI] [PubMed] [Google Scholar]
  50. Nishiya K., Chiao J. W., De Sousa M. Iron binding proteins in selected human peripheral blood cell sets: immunofluorescence. Br J Haematol. 1980 Oct;46(2):235–245. doi: 10.1111/j.1365-2141.1980.tb05962.x. [DOI] [PubMed] [Google Scholar]
  51. Phillips J. L., Azari P. Effect of iron transferrin on nucleic acid synthesis in phytohemagglutinin-stimulated human lymphocytes. Cell Immunol. 1975 Jan;15(1):94–99. doi: 10.1016/0008-8749(75)90167-7. [DOI] [PubMed] [Google Scholar]
  52. Reddy P. S., Lewis M. The adverse effect of intravenous iron-dextran in rheumatoid arthritis. Arthritis Rheum. 1969 Aug;12(4):454–457. doi: 10.1002/art.1780120413. [DOI] [PubMed] [Google Scholar]
  53. Roberts D., Davies J. Exacerbation of rheumatoid synovitis by iron-dextran infusion. Lancet. 1987 Feb 14;1(8529):391–391. doi: 10.1016/s0140-6736(87)91771-5. [DOI] [PubMed] [Google Scholar]
  54. Rogers K. R., Morris C. J., Blake D. R. Cytoskeletal rearrangement by oxidative stress. Int J Tissue React. 1989;11(6):309–314. [PubMed] [Google Scholar]
  55. Rowley D., Gutteridge J. M., Blake D., Farr M., Halliwell B. Lipid peroxidation in rheumatoid arthritis: thiobarbituric acid-reactive material and catalytic iron salts in synovial fluid from rheumatoid patients. Clin Sci (Lond) 1984 Jun;66(6):691–695. doi: 10.1042/cs0660691. [DOI] [PubMed] [Google Scholar]
  56. Schumacher H. R., Kitridou R. C. Synovitis of recent onset. A clinicopathologic study during the first month of disease. Arthritis Rheum. 1972 Sep-Oct;15(5):465–485. doi: 10.1002/art.1780150502. [DOI] [PubMed] [Google Scholar]
  57. Smith R. J., Speziale S. C., Bowman B. J. Properties of interleukin-1 as a complete secretagogue for human neutrophils. Biochem Biophys Res Commun. 1985 Aug 15;130(3):1233–1240. doi: 10.1016/0006-291x(85)91746-2. [DOI] [PubMed] [Google Scholar]
  58. Tormey D. C., Imrie R. C., Mueller G. C. Identification of transferrin as a lymphocyte growth promoter in human serum. Exp Cell Res. 1972 Sep;74(1):163–169. doi: 10.1016/0014-4827(72)90492-2. [DOI] [PubMed] [Google Scholar]
  59. Van Snick J. L., Masson P. L., Heremans J. F. The involvement of lactoferrin in the hyposideremia of acute inflammation. J Exp Med. 1974 Oct 1;140(4):1068–1084. doi: 10.1084/jem.140.4.1068. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Vogt A., Mishell R. I., Dutton R. W. Stimulation of DNA synthesis in cultures of mouse spleen cell suspensions by bovine transferrin. Exp Cell Res. 1969 Feb;54(2):195–200. doi: 10.1016/0014-4827(69)90232-8. [DOI] [PubMed] [Google Scholar]
  61. Ward P. A., Goldschmidt P., Greene N. D. Suppressive effects of metal salts on leukocyte and fibroblastic function. J Reticuloendothel Soc. 1975 Nov;18(5):313–321. [PubMed] [Google Scholar]
  62. Weinberg E. D. Iron withholding: a defense against infection and neoplasia. Physiol Rev. 1984 Jan;64(1):65–102. doi: 10.1152/physrev.1984.64.1.65. [DOI] [PubMed] [Google Scholar]
  63. Winyard P. G., Blake D. R., Chirico S., Gutteridge J. M., Lunec J. Mechanism of exacerbation of rheumatoid synovitis by total-dose iron-dextran infusion: in-vivo demonstration of iron-promoted oxidant stress. Lancet. 1987 Jan 10;1(8524):69–72. doi: 10.1016/s0140-6736(87)91909-x. [DOI] [PubMed] [Google Scholar]
  64. Yoshino S., Blake D. R., Hewitt S., Morris C., Bacon P. A. Effect of blood on the activity and persistence of antigen induced inflammation in the rat air pouch. Ann Rheum Dis. 1985 Jul;44(7):485–490. doi: 10.1136/ard.44.7.485. [DOI] [PMC free article] [PubMed] [Google Scholar]
  65. de Sousa M., Dynesius-Trentham R., Mota-Garcia F., da Silva M. T., Trentham D. E. Activation of rat synovium by iron. Arthritis Rheum. 1988 May;31(5):653–661. doi: 10.1002/art.1780310511. [DOI] [PubMed] [Google Scholar]
  66. van Asbeck B. S., Marx J. J., Struyvenberg A., Verhoef J. Functional defects in phagocytic cells from patients with iron overload. J Infect. 1984 May;8(3):232–240. doi: 10.1016/s0163-4453(84)93955-0. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES