Abstract
Following the intravenous injection of live Yersinia enterocolitica O:8, 50-69% of SHR rats developed arthritis; these rats were antibody free against all rat pathogens tested. In contrast, only 20-25% of SHR rats which had serum antibodies against Bacillus piliformis, Kilham rat virus, and Toolan H-1 virus developed arthritis. The results indicate that the microbial load of the host has a profound effect on the susceptibility to experimental arthritis.
Full text
PDF





Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Billingham M. E., Carney S., Butler R., Colston M. J. A mycobacterial 65-kD heat shock protein induces antigen-specific suppression of adjuvant arthritis, but is not itself arthritogenic. J Exp Med. 1990 Jan 1;171(1):339–344. doi: 10.1084/jem.171.1.339. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Granfors K., Viljanen M. K., Toivanen A. Measurement of immunoglobulin M, immunoglobulin G, and immunoglobulin A antibodies against Yersinia enterocolitica by enzyme-linked immunosorbent assay: comparison of lipopolysaccharide and whole bacterium as antigen. J Clin Microbiol. 1981 Jul;14(1):6–14. doi: 10.1128/jcm.14.1.6-14.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hill J. L., Yu D. T. Development of an experimental animal model for reactive arthritis induced by Yersinia enterocolitica infection. Infect Immun. 1987 Mar;55(3):721–726. doi: 10.1128/iai.55.3.721-726.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jeppsson J. O., Laurell C. B., Franzén B. Agarose gel electrophoresis. Clin Chem. 1979 Apr;25(4):629–638. [PubMed] [Google Scholar]
- Kohashi O., Kohashi Y., Takahashi T., Ozawa A., Shigematsu N. Suppressive effect of Escherichia coli on adjuvant-induced arthritis in germ-free rats. Arthritis Rheum. 1986 Apr;29(4):547–553. doi: 10.1002/art.1780290413. [DOI] [PubMed] [Google Scholar]
- Kohashi O., Kuwata J., Umehara K., Uemura F., Takahashi T., Ozawa A. Susceptibility to adjuvant-induced arthritis among germfree, specific-pathogen-free, and conventional rats. Infect Immun. 1979 Dec;26(3):791–794. doi: 10.1128/iai.26.3.791-794.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Laird W. J., Cavanaugh D. C. Correlation of autoagglutination and virulence of yersiniae. J Clin Microbiol. 1980 Apr;11(4):430–432. doi: 10.1128/jcm.11.4.430-432.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Merilahti-Palo R., Gripenberg-Lerche C., Söderström K. O., Toivanen P. Long term follow up of SHR rats with experimental yersinia associated arthritis. Ann Rheum Dis. 1992 Jan;51(1):91–96. doi: 10.1136/ard.51.1.91. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schwimmbeck P. L., Dyrberg T., Oldstone M. B. Abrogation of diabetes in BB rats by acute virus infection. Association of viral-lymphocyte interactions. J Immunol. 1988 May 15;140(10):3394–3400. [PubMed] [Google Scholar]
- Taurog J. D., Leary S. L., Cremer M. A., Mahowald M. L., Sandberg G. P., Manning P. J. Infection with Mycoplasma pulmonis modulates adjuvant- and collagen-induced arthritis in Lewis rats. Arthritis Rheum. 1984 Aug;27(8):943–946. doi: 10.1002/art.1780270816. [DOI] [PubMed] [Google Scholar]
- Thompson S. J., Rook G. A., Brealey R. J., Van der Zee R., Elson C. J. Autoimmune reactions to heat-shock proteins in pristane-induced arthritis. Eur J Immunol. 1990 Nov;20(11):2479–2484. doi: 10.1002/eji.1830201118. [DOI] [PubMed] [Google Scholar]
- Toivanen A., Merilahti-Palo R., Gripenberg C., Lahesmaa-Rantala R., Söderström K. O., Jaakkola U. M. Yersinia-associated arthritis in the rat: experimental model for human reactive arthritis? Acta Pathol Microbiol Immunol Scand C. 1986 Dec;94(6):261–269. doi: 10.1111/j.1699-0463.1986.tb02121.x. [DOI] [PubMed] [Google Scholar]
- Wauben M. H., Boog C. J., van der Zee R., Joosten I., Schlief A., van Eden W. Disease inhibition by major histocompatibility complex binding peptide analogues of disease-associated epitopes: more than blocking alone. J Exp Med. 1992 Sep 1;176(3):667–677. doi: 10.1084/jem.176.3.667. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Williams W. V., Weiner D. B., Borofsky M. A., Rubin D. H., Yui K., Greene M. I. Modulation of T cell responses with MHC-derived peptides. Immunol Res. 1992;11(1):11–23. doi: 10.1007/BF02918604. [DOI] [PubMed] [Google Scholar]
- Winfield J. B. Stress proteins, arthritis, and autoimmunity. Arthritis Rheum. 1989 Dec;32(12):1497–1504. doi: 10.1002/anr.1780321202. [DOI] [PubMed] [Google Scholar]
- Yang X. D., Gasser J., Feige U. Prevention of adjuvant arthritis in rats by a nonapeptide from the 65-kD mycobacterial heat-shock protein. Clin Exp Immunol. 1990 Aug;81(2):189–194. doi: 10.1111/j.1365-2249.1990.tb03316.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- van Eden W., Thole J. E., van der Zee R., Noordzij A., van Embden J. D., Hensen E. J., Cohen I. R. Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis. Nature. 1988 Jan 14;331(6152):171–173. doi: 10.1038/331171a0. [DOI] [PubMed] [Google Scholar]
- van den Broek M. F., Hogervorst E. J., Van Bruggen M. C., Van Eden W., van der Zee R., van den Berg W. B. Protection against streptococcal cell wall-induced arthritis by pretreatment with the 65-kD mycobacterial heat shock protein. J Exp Med. 1989 Aug 1;170(2):449–466. doi: 10.1084/jem.170.2.449. [DOI] [PMC free article] [PubMed] [Google Scholar]