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. 1993 May;52(5):365–368. doi: 10.1136/ard.52.5.365

Antinuclear antibodies in patients with scleroderma (systemic sclerosis) and in their blood relatives and spouses.

A J Barnett 1, L J McNeilage 1
PMCID: PMC1005051  PMID: 8323384

Abstract

OBJECTIVE--To test the postulate that there is a higher prevalence of antinuclear antibodies (ANAs) in serum samples from blood relatives and from spouses of patients with scleroderma than in control samples, and that this provides evidence for both genetic and environmental factors influencing autoimmunity in scleroderma. METHOD--Testing for ANAs was performed on 58 patients with scleroderma, 30 of their spouses, 74 first degree relatives, and 66 control subjects broadly age matched to the patients, their spouses, and about half of the relatives (siblings and parents). RESULTS--On the basis of an ANA titre of > 40 as positive, 12 (18%) of the controls, 55 (95%) of the patients, one (3%) of the spouses and five (7%) of the relatives would be classified as positive. Thirty seven (64%) of the patients had defined specificities (ACA, Scl 70, U1 (RNP)) but none of the controls, spouses, or relatives had antibodies of these specificities. CONCLUSION--These findings give no support to the postulate that environmental or genetic factors contribute to the ANAs in scleroderma.

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Selected References

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  1. Alarcón G. S., Phillips R. M., Wasner C. K., Acton R. T., Barger B. O. DR antigens in systemic sclerosis: lack of clinical correlations. Tissue Antigens. 1985 Aug;26(2):156–158. doi: 10.1111/j.1399-0039.1985.tb00950.x. [DOI] [PubMed] [Google Scholar]
  2. Barnett A. J., Coventry D. A. Scleroderma. 1. Clinical features, course of illness and response to treatment in 61 cases. Med J Aust. 1969 May 10;1(19):992–1001. doi: 10.5694/j.1326-5377.1969.tb49844.x. [DOI] [PubMed] [Google Scholar]
  3. Barnett A. J., Tait B. D., Barnett M. A., Toh B. H. T lymphocyte subset abnormalities and HLA antigens in scleroderma (systemic sclerosis). Clin Exp Immunol. 1989 Apr;76(1):24–29. [PMC free article] [PubMed] [Google Scholar]
  4. Black C. M., Welsh K. I., Maddison P. J., Jayson M. I., Bernstein R. M. HLA antigens, autoantibodies and clinical subsets in scleroderma. Br J Rheumatol. 1984 Nov;23(4):267–271. doi: 10.1093/rheumatology/23.4.267. [DOI] [PubMed] [Google Scholar]
  5. Brasington R. D., Jr, Thorpe-Swenson A. J. Systemic sclerosis associated with cutaneous exposure to solvent: case report and review of the literature. Arthritis Rheum. 1991 May;34(5):631–633. doi: 10.1002/art.1780340516. [DOI] [PubMed] [Google Scholar]
  6. Burge K. M., Perry H. O., Stickler G. B. "Familial" scleroderma. Arch Dermatol. 1969 Jun;99(6):681–687. [PubMed] [Google Scholar]
  7. ERASMUS L. D. Scleroderma in goldminers on the Witwatersrand with particular reference to pulmonary manifestations. S Afr J Lab Clin Med. 1957 Sep;3(3):209–231. [PubMed] [Google Scholar]
  8. Gray R. G., Altman R. D. Progressive systemic sclerosis in a family: case report of a mother and son and review of the literature. Arthritis Rheum. 1977 Jan-Feb;20(1):35–41. doi: 10.1002/art.1780200106. [DOI] [PubMed] [Google Scholar]
  9. Haustein U. F., Ziegler V., Herrmann K., Mehlhorn J., Schmidt C. Silica-induced scleroderma. J Am Acad Dermatol. 1990 Mar;22(3):444–448. doi: 10.1016/0190-9622(90)70062-m. [DOI] [PubMed] [Google Scholar]
  10. Hooper B., Whittingham S., Mathews J. D., Mackay I. R., Curnow D. H. Autoimmunity in a rural community. Clin Exp Immunol. 1972 Sep;12(1):79–87. [PMC free article] [PubMed] [Google Scholar]
  11. Kumagai Y., Shiokawa Y., Medsger T. A., Jr, Rodnan G. P. Clinical spectrum of connective tissue disease after cosmetic surgery. Observations on eighteen patients and a review of the Japanese literature. Arthritis Rheum. 1984 Jan;27(1):1–12. doi: 10.1002/art.1780270101. [DOI] [PubMed] [Google Scholar]
  12. Livingston J. Z., Scott T. E., Wigley F. M., Anhalt G. J., Bias W. B., McLean R. H., Hochberg M. C. Systemic sclerosis (scleroderma): clinical, genetic, and serologic subsets. J Rheumatol. 1987 Jun;14(3):512–518. [PubMed] [Google Scholar]
  13. Lynch C. J., Singh G., Whiteside T. L., Rodnan G. P., Medsger T. A., Jr, Rabin B. S. Histocompatibility antigens in progressive systemic sclerosis (PSS; scleroderma). J Clin Immunol. 1982 Oct;2(4):314–318. doi: 10.1007/BF00915073. [DOI] [PubMed] [Google Scholar]
  14. Maddison P. J., Skinner R. P., Pereira R. S., Black C. M., Ansell B. M., Jayson M. I., Rowell N. R., Welsh K. I. Antinuclear antibodies in the relatives and spouses of patients with systemic sclerosis. Ann Rheum Dis. 1986 Oct;45(10):793–799. doi: 10.1136/ard.45.10.793. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Maricq H. R., Johnson M. N., Whetstone C. L., LeRoy E. C. Capillary abnormalities in polyvinyl chloride production workers. Examination by in vivo microscopy. JAMA. 1976 Sep 20;236(12):1368–1371. [PubMed] [Google Scholar]
  16. McAndrew G. M., Barnes E. G. Familial scleroderma. Ann Phys Med. 1965 Nov;8(4):128–131. doi: 10.1093/rheumatology/8.4.128. [DOI] [PubMed] [Google Scholar]
  17. McGregor A. R., Watson A., Yunis E., Pandey J. P., Takehara K., Tidwell J. T., Ruggieri A., Silver R. M., LeRoy E. C., Maricq H. R. Familial clustering of scleroderma spectrum disease. Am J Med. 1988 Jun;84(6):1023–1032. doi: 10.1016/0002-9343(88)90307-5. [DOI] [PubMed] [Google Scholar]
  18. Owens G. R., Medsger T. A. Systemic sclerosis secondary to occupational exposure. Am J Med. 1988 Jul;85(1):114–116. doi: 10.1016/0002-9343(88)90515-3. [DOI] [PubMed] [Google Scholar]
  19. Rodnan G. P., Benedek T. G., Medsger T. A., Jr, Cammarata R. J. The association of progressive systemic sclerosis (scleroderma) with coal miners' pneumoconiosis and other forms of silicosis. Ann Intern Med. 1967 Feb;66(2):323–334. doi: 10.7326/0003-4819-66-2-323. [DOI] [PubMed] [Google Scholar]
  20. Sheldon W. B., Lurie D. P., Maricq H. R., Kahaleh M. B., DeLustro F. A., Gibofsky A., LeRoy E. C. Three siblings with scleroderma (systemic sclerosis) and two with Raynaud's phenomenon from a single kindred. Arthritis Rheum. 1981 May;24(5):668–676. doi: 10.1002/art.1780240507. [DOI] [PubMed] [Google Scholar]
  21. Tan E. M. Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv Immunol. 1989;44:93–151. doi: 10.1016/s0065-2776(08)60641-0. [DOI] [PubMed] [Google Scholar]
  22. Tan E. M., Rodnan G. P., Garcia I., Moroi Y., Fritzler M. J., Peebles C. Diversity of antinuclear antibodies in progressive systemic sclerosis. Anti-centromere antibody and its relationship to CREST syndrome. Arthritis Rheum. 1980 Jun;23(6):617–625. doi: 10.1002/art.1780230602. [DOI] [PubMed] [Google Scholar]
  23. Walker A. Occupational acro-osteolysis (two cases). Proc R Soc Med. 1975 Jun;68(6):343–344. [PMC free article] [PubMed] [Google Scholar]
  24. Whiteside T. L., Medsger T. A., Jr, Rodnan G. P. HLA-DR antigens in progressive systemic sclerosis (scleroderma). J Rheumatol. 1983 Feb;10(1):128–131. [PubMed] [Google Scholar]
  25. Wilson R. H., McCormick W. E., Tatum C. F., Creech J. L. Occupational acroosteolysis. Report of 31 cases. JAMA. 1967 Aug 21;201(8):577–581. doi: 10.1001/jama.201.8.577. [DOI] [PubMed] [Google Scholar]

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