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. 2023 Mar 17;28(6):2733. doi: 10.3390/molecules28062733

Table 1.

Mechanism of action of Re complexes and cancer cell lines they act on.

Compound Cell Line Mechanism of Action Ref.
Re-1a HPAF-II, ASPC1, CFPAC Inhibit Growth [81]
Re-2a A2780, A2780CP70 Inhibit Growth [82]
Re-3a A2780, A2780CP70 Cell Necrosis [83]
Re-4a A549 Cell Necrosis [84]
Re-4b A549 Cell Necrosis [84]
Re-5a A431, DLD-1, A2780 Cell Apoptosis [85]
Re-6a HeLa Cell Apoptosis and Ferroptosis [86]
Re-7a Guerink (T-8) Cell Apoptosis [87]
Re-8a A549, HCT-15, HeLa, K562 Cell Apoptosis [88]
Re-9a A2780 Cell Apoptosis [89]
Re-10a A549 Photodynamic Therapy [90]
Re-10b A549 Photodynamic Therapy [90]
Re-11a HeLa Photodynamic Therapy [91]
Re-12a HeLa, H460M2, HBL-100 Photodynamic Therapy [92]
Re-13a HeLa Photodynamic Therapy [93]
Re-13b HeLa Photodynamic Therapy [93]
Re-14a A2780, A2780cis Photodynamic Therapy [94]
Re-15a HeLa, A2780, A2780CP70 Photodynamic Therapy [95]
Re-16a PC-3, MDA-MB-231, CCl-227 Insert DNA [96]
Re-17a PC-3 Insert DNA [97]
Re-18a / Base Bind [98]
Re-19a / Base Bind [99]
Re-20a / DNA Groove Bind [100]
Re-21a T98G, PC3, MCF-7 DNA Groove Bind [101]
Re-22a A2780/AD DNA Groove Bind [102]
Re-23a BeWo DNA Groove Bind [103]
Re-24a NCI-1229 Cell Apoptosis [104]
Re-25a HepG2, HeLa, MCF-7, A549 Cell Apoptosis [105]
Re-26a MCF-7 Cell Apoptosis [106]
Re-27a HeLa, A549, MCF-7 Cell Apoptosis [107]
Re-27b HeLa, A549, MCF-7 Cell Apoptosis [107]
Re-28a A549 Cell Apoptosis [108]
Re-29a HeLa Cell Apoptosis [109]
Re-30a NALM-6, BJAB, MelHO Cell Apoptosis [110]
Re-31a HeLa, A549, HepG2 Cell Apoptosis [111]
Re-31b HeLa, A549, HepG2 Cell Paraptosis [111]
Re-32a 4T1 Sonodynamic–Gas Therapy [112]
Re-33a MDA-MB-231 Photodynamic and Immunotherapy [113]
Re-34a HeLa Cell Apoptosis [114]