Skip to main content
NCBI home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1994 Feb;53(2):106–111. doi: 10.1136/ard.53.2.106

Does parvovirus B19 have a role in rheumatoid arthritis?

S Nikkari 1, R Luukkainen 1, T Möttönen 1, O Meurman 1, P Hannonen 1, M Skurnik 1, P Toivanen 1
PMCID: PMC1005261  PMID: 8129454

Abstract

OBJECTIVES--To determine whether parvovirus B19 (B19) infection is associated with rheumatoid arthritis (RA). METHODS--The polymerase chain reaction was applied to serum, cells isolated from synovial fluid, and synovial fluid. Enzyme immunoassay technique was used to detect antibodies against B19. RESULTS--Of 142 patients with early RA (onset of disease under one year) and 67 control patients, serological evidence of recent parvoviral infection was found in 4/135 and 2/62, respectively. However, no evidence for the presence of parvoviral DNA was observed in 18 synovial fluids, 21 samples of synovial fluid granulocytes or 40 sera, all obtained from 65 patients diagnosed with early RA. CONCLUSION--Although there is published evidence of chronic rheumatoid-like arthropathy following acute parvovirus infection, our findings do not support the involvement of B19 in the aetiopathogenesis of RA.

Full text

PDF
106

Images in this article

109Image
on p.109

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anand A., Gray E. S., Brown T., Clewley J. P., Cohen B. J. Human parvovirus infection in pregnancy and hydrops fetalis. N Engl J Med. 1987 Jan 22;316(4):183–186. doi: 10.1056/NEJM198701223160403. [DOI] [PubMed] [Google Scholar]
  2. Anderson M. J., Jones S. E., Fisher-Hoch S. P., Lewis E., Hall S. M., Bartlett C. L., Cohen B. J., Mortimer P. P., Pereira M. S. Human parvovirus, the cause of erythema infectiosum (fifth disease)? Lancet. 1983 Jun 18;1(8338):1378–1378. doi: 10.1016/s0140-6736(83)92152-9. [DOI] [PubMed] [Google Scholar]
  3. Arnett F. C., Edworthy S. M., Bloch D. A., McShane D. J., Fries J. F., Cooper N. S., Healey L. A., Kaplan S. R., Liang M. H., Luthra H. S. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988 Mar;31(3):315–324. doi: 10.1002/art.1780310302. [DOI] [PubMed] [Google Scholar]
  4. Bauer H. M., Ting Y., Greer C. E., Chambers J. C., Tashiro C. J., Chimera J., Reingold A., Manos M. M. Genital human papillomavirus infection in female university students as determined by a PCR-based method. JAMA. 1991 Jan 23;265(4):472–477. [PubMed] [Google Scholar]
  5. Clewley J. P. Polymerase chain reaction assay of parvovirus B19 DNA in clinical specimens. J Clin Microbiol. 1989 Dec;27(12):2647–2651. doi: 10.1128/jcm.27.12.2647-2651.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cohen B. J., Buckley M. M., Clewley J. P., Jones V. E., Puttick A. H., Jacoby R. K. Human parvovirus infection in early rheumatoid and inflammatory arthritis. Ann Rheum Dis. 1986 Oct;45(10):832–838. doi: 10.1136/ard.45.10.832. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Dijkmans B. A., van Elsacker-Niele A. M., Salimans M. M., van Albada-Kuipers G. A., de Vries E., Weiland H. T. Human parvovirus B19 DNA in synovial fluid. Arthritis Rheum. 1988 Feb;31(2):279–281. doi: 10.1002/art.1780310218. [DOI] [PubMed] [Google Scholar]
  8. Fridell E., Cohen B. J., Wahren B. Evaluation of a synthetic-peptide enzyme-linked immunosorbent assay for immunoglobulin M to human parvovirus B19. J Clin Microbiol. 1991 Jul;29(7):1376–1381. doi: 10.1128/jcm.29.7.1376-1381.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kandolf R., Kirschner P., Hofschneider P. H., Vischer T. L. Detection of parvovirus in a patient with "reactive arthritis" by in situ hybridization. Clin Rheumatol. 1989 Sep;8(3):398–401. doi: 10.1007/BF02030355. [DOI] [PubMed] [Google Scholar]
  10. Koch W. C., Adler S. P. Detection of human parvovirus B19 DNA by using the polymerase chain reaction. J Clin Microbiol. 1990 Jan;28(1):65–69. doi: 10.1128/jcm.28.1.65-69.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kurtzman G. J., Gascon P., Caras M., Cohen B., Young N. S. B19 parvovirus replicates in circulating cells of acutely infected patients. Blood. 1988 May;71(5):1448–1454. [PubMed] [Google Scholar]
  12. Kwok S., Higuchi R. Avoiding false positives with PCR. Nature. 1989 May 18;339(6221):237–238. doi: 10.1038/339237a0. [DOI] [PubMed] [Google Scholar]
  13. Lefrere J. J., Meyer O., Menkes C. J., Beaulieu M. J., Couroucé A. M. Human parvovirus and rheumatoid arthritis. Lancet. 1985 Apr 27;1(8435):982–982. doi: 10.1016/s0140-6736(85)91751-9. [DOI] [PubMed] [Google Scholar]
  14. Meurman O. H. Persistence of immunoglobulin G and immunoglobulin M antibodies after postnatal rubella infection determined by solid-phase radioimmunoassay. J Clin Microbiol. 1978 Jan;7(1):34–38. doi: 10.1128/jcm.7.1.34-38.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Naides S. J., Scharosch L. L., Foto F., Howard E. J. Rheumatologic manifestations of human parvovirus B19 infection in adults. Initial two-year clinical experience. Arthritis Rheum. 1990 Sep;33(9):1297–1309. doi: 10.1002/art.1780330901. [DOI] [PubMed] [Google Scholar]
  16. Nikkari S., Merilahti-Palo R., Saario R., Söderström K. O., Granfors K., Skurnik M., Toivanen P. Yersinia-triggered reactive arthritis. Use of polymerase chain reaction and immunocytochemical staining in the detection of bacterial components from synovial specimens. Arthritis Rheum. 1992 Jun;35(6):682–687. doi: 10.1002/art.1780350613. [DOI] [PubMed] [Google Scholar]
  17. Nikkari S., Meurman O., Wanne O. Parvovirus B19 and transient erythroblastopenia of childhood. Br J Haematol. 1993 Apr;83(4):679–679. doi: 10.1111/j.1365-2141.1993.tb04716.x. [DOI] [PubMed] [Google Scholar]
  18. Phillips P. E. Evidence implicating infectious agents in rheumatoid arthritis and juvenile rheumatoid arthritis. Clin Exp Rheumatol. 1988 Jan-Mar;6(1):87–94. [PubMed] [Google Scholar]
  19. Saiki R. K., Gelfand D. H., Stoffel S., Scharf S. J., Higuchi R., Horn G. T., Mullis K. B., Erlich H. A. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science. 1988 Jan 29;239(4839):487–491. doi: 10.1126/science.2448875. [DOI] [PubMed] [Google Scholar]
  20. Salimans M. M., Holsappel S., van de Rijke F. M., Jiwa N. M., Raap A. K., Weiland H. T. Rapid detection of human parvovirus B19 DNA by dot-hybridization and the polymerase chain reaction. J Virol Methods. 1989 Jan;23(1):19–28. doi: 10.1016/0166-0934(89)90085-2. [DOI] [PubMed] [Google Scholar]
  21. Sevall J. S. Detection of parvovirus B19 by dot-blot and polymerase chain reaction. Mol Cell Probes. 1990 Jun;4(3):237–246. doi: 10.1016/0890-8508(90)90057-7. [DOI] [PubMed] [Google Scholar]
  22. Shade R. O., Blundell M. C., Cotmore S. F., Tattersall P., Astell C. R. Nucleotide sequence and genome organization of human parvovirus B19 isolated from the serum of a child during aplastic crisis. J Virol. 1986 Jun;58(3):921–936. doi: 10.1128/jvi.58.3.921-936.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Simpson R. W., McGinty L., Simon L., Smith C. A., Godzeski C. W., Boyd R. J. Association of parvoviruses with rheumatoid arthritis of humans. Science. 1984 Mar 30;223(4643):1425–1428. doi: 10.1126/science.6701529. [DOI] [PubMed] [Google Scholar]
  24. Söderlund M., Brown K. E., Meurman O., Hedman K. Prokaryotic expression of a VP1 polypeptide antigen for diagnosis by a human parvovirus B19 antibody enzyme immunoassay. J Clin Microbiol. 1992 Feb;30(2):305–311. doi: 10.1128/jcm.30.2.305-311.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Tamm A., Ziegler T., Lautenschlager I., Nikkari S., Möttönen T., Luukkainen R., Skurnik M., Toivanen P. Detection of cytomegalovirus DNA in cells from synovial fluid and peripheral blood of patients with early rheumatoid arthritis. J Rheumatol. 1993 Sep;20(9):1489–1493. [PubMed] [Google Scholar]
  26. White D. G., Woolf A. D., Mortimer P. P., Cohen B. J., Blake D. R., Bacon P. A. Human parvovirus arthropathy. Lancet. 1985 Feb 23;1(8426):419–421. doi: 10.1016/s0140-6736(85)91145-6. [DOI] [PubMed] [Google Scholar]
  27. Young N. Hematologic and hematopoietic consequences of B19 parvovirus infection. Semin Hematol. 1988 Apr;25(2):159–172. [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES