Abstract
OBJECTIVES--To determine whether polymorphisms of the TAP genes, which lie within the major histocompatibility complex (MHC), are associated with juvenile chronic arthritis (JCA). METHODS--Eighty five JCA patients and 166 white controls were typed for the TAP gene alleles using ARMS-PCR. The same populations were analysed for DRB1 and DPB1 alleles using PCR-SSO typing. RESULTS--TAP2B was increased in early onset pauciarticular JCA (EOPA-JCA) compared with controls (62% v 44% Odds ratio (OR) 2.1, 95% CI 0.9-4.7). After allowing for the known linkage disequilibrium between TAP2B and DR1 the association of TAP2B and EOPA-JCA was maintained (OR 3.5, 95% CI 1.3-9.7). HLA-DRB1*04 and TAP2D were found to be in linkage disequilibrium in both the control (delta 0.018 p < 0.05) and JCA patient groups (delta 0.021 p < 0.05). No linkage disequilibrium was found between the TAP and DPB1 alleles. CONCLUSIONS--The association between TAP2B and EOPA-JCA is a further indication of the heterogeneity which exists in this clinically defined subgroup of patients.
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- Colonna M., Bresnahan M., Bahram S., Strominger J. L., Spies T. Allelic variants of the human putative peptide transporter involved in antigen processing. Proc Natl Acad Sci U S A. 1992 May 1;89(9):3932–3936. doi: 10.1073/pnas.89.9.3932. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kleijmeer M. J., Kelly A., Geuze H. J., Slot J. W., Townsend A., Trowsdale J. Location of MHC-encoded transporters in the endoplasmic reticulum and cis-Golgi. Nature. 1992 May 28;357(6376):342–344. doi: 10.1038/357342a0. [DOI] [PubMed] [Google Scholar]
- Malnati M. S., Marti M., LaVaute T., Jaraquemada D., Biddison W., DeMars R., Long E. O. Processing pathways for presentation of cytosolic antigen to MHC class II-restricted T cells. Nature. 1992 Jun 25;357(6380):702–704. doi: 10.1038/357702a0. [DOI] [PubMed] [Google Scholar]
- Morling N., Friis J., Fugger L., Georgsen J., Heilmann C., Pedersen F. K., Odum N., Svejgaard A. DNA polymorphism of HLA class II genes in pauciarticular juvenile rheumatoid arthritis. Tissue Antigens. 1991 Jul;38(1):16–23. doi: 10.1111/j.1399-0039.1991.tb02030.x. [DOI] [PubMed] [Google Scholar]
- Paul C., Schoenwald U., Truckenbrodt H., Bettinotti M. P., Brünnler G., Keller E., Nevinny-Stickel C., Yao Z., Albert E. D. HLA-DP/DR interaction in early onset pauciarticular juvenile chronic arthritis. Immunogenetics. 1993;37(6):442–448. doi: 10.1007/BF00222468. [DOI] [PubMed] [Google Scholar]
- Powis S. H., Mockridge I., Kelly A., Kerr L. A., Glynne R., Gileadi U., Beck S., Trowsdale J. Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex. Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1463–1467. doi: 10.1073/pnas.89.4.1463. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Powis S. H., Tonks S., Mockridge I., Kelly A. P., Bodmer J. G., Trowsdale J. Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2. Immunogenetics. 1993;37(5):373–380. doi: 10.1007/BF00216802. [DOI] [PubMed] [Google Scholar]
- Powis S. J., Deverson E. V., Coadwell W. J., Ciruela A., Huskisson N. S., Smith H., Butcher G. W., Howard J. C. Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule. Nature. 1992 May 21;357(6375):211–215. doi: 10.1038/357211a0. [DOI] [PubMed] [Google Scholar]