Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1994 May;53(5):327–330. doi: 10.1136/ard.53.5.327

Cerebellum and brainstem vasculopathy in systemic lupus erythematosus: two clinico-pathological cases.

R W Smith 1, D W Ellison 1, E A Jenkins 1, P J Gallagher 1, M I Cawley 1
PMCID: PMC1005332  PMID: 8017987

Abstract

The case histories are reported of two patients with systemic lupus erythematosus (SLE) who developed fatal neurological involvement, each presenting with cerebellar and brainstem signs. Neuro-pathological changes were confined to the cerebellum and brainstem, with clear evidence of a small vessel vasculopathy. The predominant histological abnormalities were multiple perivascular haemorrhages in one case and classical vasculitic changes in the other.

Full text

PDF
327

Images in this article

328Image
on p.328
329Image
on p.329

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adelman D. C., Saltiel E., Klinenberg J. R. The neuropsychiatric manifestations of systemic lupus erythematosus: an overview. Semin Arthritis Rheum. 1986 Feb;15(3):185–199. doi: 10.1016/0049-0172(86)90016-8. [DOI] [PubMed] [Google Scholar]
  2. Bunning R. D., Laureno R., Barth W. F. Florid central nervous system vasculitis in a fatal case of systemic lupus erythematosus. J Rheumatol. 1982 Sep-Oct;9(5):735–738. [PubMed] [Google Scholar]
  3. Devinsky O., Petito C. K., Alonso D. R. Clinical and neuropathological findings in systemic lupus erythematosus: the role of vasculitis, heart emboli, and thrombotic thrombocytopenic purpura. Ann Neurol. 1988 Apr;23(4):380–384. doi: 10.1002/ana.410230411. [DOI] [PubMed] [Google Scholar]
  4. Ellis S. G., Verity M. A. Central nervous system involvement in systemic lupus erythematosus: a review of neuropathologic findings in 57 cases, 1955--1977. Semin Arthritis Rheum. 1979 Feb;8(3):212–221. doi: 10.1016/s0049-0172(79)80009-8. [DOI] [PubMed] [Google Scholar]
  5. Ellison D., Gatter K., Heryet A., Esiri M. Intramural platelet deposition in cerebral vasculopathy of systemic lupus erythematosus. J Clin Pathol. 1993 Jan;46(1):37–40. doi: 10.1136/jcp.46.1.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Feinglass E. J., Arnett F. C., Dorsch C. A., Zizic T. M., Stevens M. B. Neuropsychiatric manifestations of systemic lupus erythematosus: diagnosis, clinical spectrum, and relationship to other features of the disease. Medicine (Baltimore) 1976 Jul;55(4):323–339. doi: 10.1097/00005792-197607000-00004. [DOI] [PubMed] [Google Scholar]
  7. Hanly J. G., Walsh N. M., Sangalang V. Brain pathology in systemic lupus erythematosus. J Rheumatol. 1992 May;19(5):732–741. [PubMed] [Google Scholar]
  8. Johnson R. T., Richardson E. P. The neurological manifestations of systemic lupus erythematosus. Medicine (Baltimore) 1968 Jul;47(4):337–369. doi: 10.1097/00005792-196807000-00002. [DOI] [PubMed] [Google Scholar]
  9. Sergent J. S., Lockshin M. D., Klempner M. S., Lipsky B. A. Central nervous system disease in systemic lupus erythematosus. Therapy and prognosis. Am J Med. 1975 May;58(5):644–654. doi: 10.1016/0002-9343(75)90500-8. [DOI] [PubMed] [Google Scholar]
  10. Sibbitt W. L., Jr, Sibbitt R. R., Griffey R. H., Eckel C., Bankhurst A. D. Magnetic resonance and computed tomographic imaging in the evaluation of acute neuropsychiatric disease in systemic lupus erythematosus. Ann Rheum Dis. 1989 Dec;48(12):1014–1022. doi: 10.1136/ard.48.12.1014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Sibley J. T., Olszynski W. P., Decoteau W. E., Sundaram M. B. The incidence and prognosis of central nervous system disease in systemic lupus erythematosus. J Rheumatol. 1992 Jan;19(1):47–52. [PubMed] [Google Scholar]
  12. Singh R. R., Prasad K., Kumar A., Misra A., Padmakumar K., Malaviya A. N. Cerebellar ataxia in systemic lupus erythematosus: three case reports. Ann Rheum Dis. 1988 Nov;47(11):954–956. doi: 10.1136/ard.47.11.954. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Tuchman A. J., Daras M., David S. Cerebellar ataxia in systemic lupus erythematosus. N Y State J Med. 1983 Jun;83(7):983–984. [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES