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. 1994 Oct;53(10):671–674. doi: 10.1136/ard.53.10.671

Autonomic neuropathy in systemic lupus erythematosus: cardiovascular autonomic function assessment.

F Lioté 1, C K Osterland 1
PMCID: PMC1005434  PMID: 7979580

Abstract

AIM--To assess the prevalence and the nature of autonomic neuropathy (AN) in 17 patients with inactive or mild active systemic lupus erythematosus (SLE). METHODS--Patients were tested using questionnaires related to possible AN symptoms, and four non invasive cardiovascular autonomic function tests at rest, during lying to standing, and sustained handgrip. Eleven age matched normal subjects were also enrolled as a control group. RESULTS--At least one abnormal cardiovascular autonomic function test was observed in 15 of the 17 patients. The two groups did not differ in deep-breathing (parasympathetic, PS) and handgrip tests (sympathetic, S) although responses in patients with SLE tended towards abnormal values. Statistical differences were found in standing-heart rate ratio (R-R ratio) (PS) with a lower ratio in the group with SLE (p < 0.01) and in standing blood pressure with a higher decrease in systolic blood pressure (p < 0.05) in patients with SLE. No correlation was found between AN, age, disease duration and presence of Raynaud's phenomenon. CONCLUSION--In inactive or mild active SLE, AN could represent residual abnormalities of autonomic nervous system involvement and/or could be related to glucocorticoids.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Appenzeller O., Arnason B. G., Adams R. D. Experimental autonomic neuropathy: an immunologically induced disorder of reflex vasomotor function. J Neurol Neurosurg Psychiatry. 1965 Dec;28(6):510–515. doi: 10.1136/jnnp.28.6.510. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Baerwald C., Graefe C., Muhl C., Von Wichert P., Krause A. Beta 2-adrenergic receptors on peripheral blood mononuclear cells in patients with rheumatic diseases. Eur J Clin Invest. 1992 Oct;22 (Suppl 1):42–46. [PubMed] [Google Scholar]
  3. Dessein P. H., Joffe B. I., Metz R. M., Millar D. L., Lawson M., Stanwix A. E. Autonomic dysfunction in systemic sclerosis: sympathetic overactivity and instability. Am J Med. 1992 Aug;93(2):143–150. doi: 10.1016/0002-9343(92)90043-b. [DOI] [PubMed] [Google Scholar]
  4. Edelman J., Gubbay S. S., Zilko P. J. Acute pandysautonomia due to mixed connective tissue disease. Aust N Z J Med. 1981 Feb;11(1):68–70. doi: 10.1111/j.1445-5994.1981.tb03740.x. [DOI] [PubMed] [Google Scholar]
  5. Edmonds M. E., Jones T. C., Saunders W. A., Sturrock R. D. Autonomic neuropathy in rheumatoid arthritis. Br Med J. 1979 Jul 21;2(6183):173–175. doi: 10.1136/bmj.2.6183.173. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ewing D. J., Campbell I. W., Clarke B. F. Assessment of cardiovascular effects in diabetic autonomic neuropathy and prognostic implications. Ann Intern Med. 1980 Feb;92(2 Pt 2):308–311. doi: 10.7326/0003-4819-92-2-308. [DOI] [PubMed] [Google Scholar]
  7. Ewing D. J., Clarke B. F. Diagnosis and management of diabetic autonomic neuropathy. Br Med J (Clin Res Ed) 1982 Oct 2;285(6346):916–918. doi: 10.1136/bmj.285.6346.916. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Ewing D. J., Winney R. Autonomic function in patients with chronic renal failure on intermittent haemodialysis. Nephron. 1975;15(6):424–429. doi: 10.1159/000180525. [DOI] [PubMed] [Google Scholar]
  9. Gudesblatt M., Goodman A. D., Rubenstein A. E., Bender A. N., Choi H. S. Autonomic neuropathy associated with autoimmune disease. Neurology. 1985 Feb;35(2):261–264. doi: 10.1212/wnl.35.2.261. [DOI] [PubMed] [Google Scholar]
  10. Guzmán J., Cardiel M. H., Arce-Salinas A., Sánchez-Guerrero J., Alarcón-Segovia D. Measurement of disease activity in systemic lupus erythematosus. Prospective validation of 3 clinical indices. J Rheumatol. 1992 Oct;19(10):1551–1558. [PubMed] [Google Scholar]
  11. Harik S. I., Ghandour M. H., Farah F. S., Afifi A. K. Postganglionic cholinergic dysautonomia. Ann Neurol. 1977 Apr;1(4):393–396. doi: 10.1002/ana.410010411. [DOI] [PubMed] [Google Scholar]
  12. Henrich W. L. Autonomic insufficiency. Arch Intern Med. 1982 Feb;142(2):339–344. [PubMed] [Google Scholar]
  13. Hosking D. J., Bennett T., Hampton J. R. Diabetic autonomic neuropathy. Diabetes. 1978 Oct;27(10):1043–1055. doi: 10.2337/diab.27.10.1043. [DOI] [PubMed] [Google Scholar]
  14. Hoyle C., Ewing D. J., Parker A. C. Acute autonomic neuropathy in association with systemic lupus erythematosus. Ann Rheum Dis. 1985 Jun;44(6):420–424. doi: 10.1136/ard.44.6.420. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Magarò M., Mirone L., Altomonte L., Zoli A., Angelosante S. Lack of correlation between anticardiolipin antibodies and peripheral autonomic nerve involvement in systemic lupus erythematosus. Clin Rheumatol. 1992 Jun;11(2):231–234. doi: 10.1007/BF02207963. [DOI] [PubMed] [Google Scholar]
  16. Tan E. M., Cohen A. S., Fries J. F., Masi A. T., McShane D. J., Rothfield N. F., Schaller J. G., Talal N., Winchester R. J. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982 Nov;25(11):1271–1277. doi: 10.1002/art.1780251101. [DOI] [PubMed] [Google Scholar]
  17. Victor D. I., Green W. R., Stark W. J., Walsh F. B. A non-permanent tonic pupil in rheumatoid arteritis. Can J Neurol Sci. 1977 Aug;4(3):209–212. doi: 10.1017/s0317167100025245. [DOI] [PubMed] [Google Scholar]

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