Table A1.
Overview of measured exposure biomarkers of 12 phthalate parent compounds.
| Phthalate Diester | Acronym | Classification as Reproductive Toxicant According to Regulation (EC) No 1272/2008 | Identification as SVHC under REACH | REACH | CoRAP |
|---|---|---|---|---|---|
| Di(2-ethylhexyl) phthalate | DEHP | Repr. 1B (2001) | Toxic for reproduction (2008); Endocrine disrupting properties ENV, HH (2014, 2017) |
Subject to Authorization since 2015 (Annex XVI); Restriction in toys, childcare (2005) and any plasticized articles since 2020 (Annex XVII) |
|
| Di-n-butyl phthalate | DnBP | Repr. 1B (2001) | Toxic for reproduction (2008); Endocrine disrupting properties HH (2017) |
Restriction in toys, childcare (2005) and any plasticized articles since 2020 (Annex XVII) | |
| Di-isobutyl phthalate | DiBP | Repr. 1B (2009) | Toxic for reproduction (2008); Endocrine disrupting properties HH (2017) |
Subject to Authorization since 2015 (Annex XVI); Restriction in toys, childcare (2005) and any plasticized articles since 2020 | |
| Butyl benzyl phthalate | BBzP | Repr. 1B (2004) | Toxic for reproduction (2008); Endocrine disrupting properties HH (2017) |
Subject to Authorization since 2015 (Annex XVI); Restriction in toys, childcare (2005) and any plasticized articles since 2020 (Annex XVII) | |
| Diethyl phthalate | DEP | No ED properties HH | |||
| Di-isodecyl phthalate (and 1 DPHP) | DiDP | Restriction in toys, childcare articles since 2005 (Annex XVII) 2 | |||
| Di-isononyl phthalate | DiNP | Restriction in toys, childcare articles since 2005 (Annex XVII) | |||
| Bis(2-propylheptyl) phthalate | DPHP | Evaluation for ED potential | |||
| Dicyclohexyl phthalate | DCHP | Repr. 1B (2016) | Toxic for reproduction (2018); Endocrine disrupting properties HH (2018) |
Evaluation for ED properties ENV | |
| Dimethyl phthalate | DMP | ||||
| Di-n-pentyl phthalate | DnPeP | Repr. 1B (2004) | Toxic for reproduction (2013) | Subject to Authorization since 2020 (Annex XVI) | |
| Di-n-octyl phthalate | DnOP | Restriction in toys, childcare articles since 2005 (Annex XVII) |
REACH: Regulation (EC) No 1907/2006; CoRAP: Community Rolling Action Plan; Repr. 1B: Classification as reproductive toxicant, Category 1B (probably reprotoxic to humans, based on chronic animal studies); ENV: for the environment; HH: for human health; ED: endocrine disrupting.1 The analytical method applied cannot distinguish between DiDP and DPHP metabolites. 2 Only applies to DiDP.