Figure 11.

(a) Schematic illustration of the proposed photodynamic/chemodynamic theranostic platform based on TPCI/MMT for efficient bacterial eradication and fast wound healing. (b) ESR spectra of TPCI/MMT for the detection of •OH (left) and ¹O₂ (right) with DMPO before and after illumination. (c) The survival rate of (left) E. coli and (right) S. aureus treated with MMT (0.5 mg·mL⁻¹) and TPCI/MMT (0.5 mg·mL⁻¹) with or without light irradiation (4 mW·cm⁻²). (d) SEM images of E. coli bacteria treated with PBS, MMT (0.1 mg·mL⁻¹), and TPCI/MMT (0.1 mg·mL⁻¹). (e) The schematic illustration of drug administration, light treatment, and wound evaluation regimens toward P. aeruginosa-infected mice. (f) Representative images of infected skin wounds after various treatments at different time points (0, 2, 4, 8, and 12 days). Scale bar: 50 mm. (g) Assessment of wound healing rate. (h) P. aeruginosa bacteria colony removed from the wound area and cultured on LB agar plates; images at days 2, 8, and 14. Adapted from [81], copyright 2022, American Chemical Society.