Abstract
(1) An epidemiological study of a rural African community has been carried out in the Western Transvaal. Altogether 801 respondents over 15 years old were examined; radiographs of the hands and feet were obtained in all these individuals. Serological tests for rheumatoid factor were carried out on 516 blood samples. (2) The diagnosis of inflammatory polyarthritis was based on a modification of the Rome Criteria of 1961. Two categories were defined: 'definite' and 'probable' rheumatoid arthritis. (3) In this population inflammatory polyarthritis was much less common and much milder in its manifestations than in European and American peoples. The prevalence of 'definite' rheumatoid arthritis was 0.12% and of 'definite' and 'probable' rheumatoid arthritis combined, 0.87. Such changes as were encountered on clinical and radiological examination were invariably mild; no respondent in the entire survey had clinical features that would have been accepted in the ordinary way as those of rheumatoid arthritis. (4) The latex fixation test (LFT) was positive in 8.9% of the sera tested; the modified LFT aftaer inactivation of the serum at 56 degrees C was positive in 15.1% of cases. Similar findings in West African populations have been explained on the basis of alteration of the immune response by widespread parasitic infections. No obvious aetiological factor of this type was found in the present survey.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Abe M., Chinone S., Hirako T. Rheumatoid-factor-like substance and antistreptolysin O antibody in leprosy serum. Significance in erythema nodosum leprosum. Int J Lepr Other Mycobact Dis. 1967 Jul-Sep;35(3):336–344. [PubMed] [Google Scholar]
- Adler E., Abramson J. H., Goldberg R., Elkan Z., Hador S. B. Rheumatoid arthritis in a Jerusalem population. II. Epidemiology of rheumatoid factors. Am J Epidemiol. 1967 May;85(3):378–386. doi: 10.1093/oxfordjournals.aje.a120699. [DOI] [PubMed] [Google Scholar]
- BUNIM J. J., BURCH T. A., O'BRIEN W. M. INFLUENCE OF GENETIC AND ENVIRONMENTAL FACTORS ON THE OCCURENCE OF RHEUMATOID ARTHRITIS AND RHEUMATOID FACTOR IN AMERICAN INDIANS. Bull Rheum Dis. 1964 Sep;15:349–350. [PubMed] [Google Scholar]
- Bartfeld H. Distribution of rheumatoid factor activity in nonrheumatoid states. Ann N Y Acad Sci. 1969 Dec 10;168(1):30–40. doi: 10.1111/j.1749-6632.1969.tb43092.x. [DOI] [PubMed] [Google Scholar]
- CATHCART E. S., WILLIAMS R. C., Jr, ROSS H., CALKINS E. The relationship of the latex fixation test to the clinical and serologic manifestations of leprosy. Am J Med. 1961 Nov;31:758–765. doi: 10.1016/0002-9343(61)90160-7. [DOI] [PubMed] [Google Scholar]
- COBB S., WARREN J. E., MERCHANT W. R., THOMPSON D. J. An estimate of the prevalence of rheumatoid arthritis. J Chronic Dis. 1957 Jun;5(6):636–643. doi: 10.1016/0021-9681(57)90073-5. [DOI] [PubMed] [Google Scholar]
- DIAGNOSTIC criteria for rheumatoid arthritis: 1958 revision by a committee of the American Rheumatism Association. Ann Rheum Dis. 1959 Mar;18(1):49–53. [PMC free article] [PubMed] [Google Scholar]
- Gelfand M. "Medical" arthritis in African practice. Cent Afr J Med. 1969 Jun;15(6):131–135. [PubMed] [Google Scholar]
- Greenwood B. M. Autoimmune disease and parasitic infections in Nigerians. Lancet. 1968 Aug 17;2(7564):380–382. doi: 10.1016/s0140-6736(68)90595-3. [DOI] [PubMed] [Google Scholar]
- HOLLEY H. L., HAMMACK W. J., DOUGLAS C. The application of the sensitized sheep cell test to sera of patients with nonrheumatic diseases and false positive serological reactions for rheumatoid arthritis. Am J Med Sci. 1961 Sep;242:331–337. doi: 10.1097/00000441-196109000-00008. [DOI] [PubMed] [Google Scholar]
- Houba V., Allison A. C. M-antiglobulins (rheumatoid-factor-like globulins) and other gamma-globulins in relation to tropical parasitic infections. Lancet. 1966 Apr 16;1(7442):848–852. doi: 10.1016/s0140-6736(66)90186-3. [DOI] [PubMed] [Google Scholar]
- Kanyerezi B. R., Baddeley H., Kisumba D. Rheumatoid arthritis in Ugandan Africans. Ann Rheum Dis. 1970 Nov;29(6):617–621. doi: 10.1136/ard.29.6.617. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kanyerezi B. R. Rheumatoid arthritis in Uganda. East Afr Med J. 1969 Jan;46(1):71–75. [PubMed] [Google Scholar]
- Klein F., Mattern P. rheumatoid factors in primary and reactive macroglobulinaemia. Ann Rheum Dis. 1965 Sep;24(5):458–464. doi: 10.1136/ard.24.5.458. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lawrence J. S., Behrend T., Bennett P. H., Bremner J. M., Burch T. A., Gofton J., O'Brien W., Robinson H. Geographical studies on rheumatoid arthritis. Ann Rheum Dis. 1966 Sep;25(5):425–432. doi: 10.1136/ard.25.5.425. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SINGER J. M., PLOTZ C. M., PERLATA F. M., LYONS H. C. The presence of anti-gamma globulin factors in sera of patients with active pulmonary tuberculosis. Ann Intern Med. 1962 Apr;56:545–552. doi: 10.7326/0003-4819-56-4-545. [DOI] [PubMed] [Google Scholar]