REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-HIF-1α rabbit monoclonal antibody, clone D1S7W (Western blot)	Cell Signaling Technology Inc.	36169; RRID: AB_2799095
anti-α-tubulin mouse monoclonal antibody, clone DM1A (Western blot)	Cell Signaling Technology Inc.	3873; RRID: AB_1904178
Anti-PGC-1alpha rabbit polyclonal (IHC)	Abcam	Ab84139; RRID: AB_1860776
Anti-NDUFA9 mouse monoclonal, clone 20C11B11B11 (IHC)	Abcam	Ab14713; RRID: AB_301431
Biological samples
Tissue microarray in paraffin (human normal organs, custom)	IRIC Histology Platform, University of Montreal	N/A
Human skin (unexposed forearm) sections in paraffin (young and aged non-diseased women)	Pageon et al.70	N/A
Chemicals, peptides, and recombinant proteins
Capryloyl salicylic acid (C8-SA)	L’OREAL/ NOVEAL	N/A
Dimethyl-2-oxoglutarate (dimethyl-2OG)	MilliporeSigma	349631
Lipofectamine 2000	Thermo Fisher Scientific	11668027
Lipofectamine RNAiMAX	Thermo Fisher Scientific	13778075
HiPerFect Transfrection Reagent	QIAGEN	301704
4 siRNA duplexes against human PPARGC1A	QIAGEN	SI00101024, SI00101031, SI02639826, SI02639833
4 siRNA duplexes against human PPARGC1B	QIAGEN	SI03043306, SI0310431, SI00150024, SI02647911
AllStars non-targeting control siRNA	QIAGEN	SI03650318
13C5-L-glutamine	Cambridge Laboratories Inc.	CLM-1822
Western Lightning® Plus-ECL enhanced chemiluminescence substrate	Perkin-Elmer	NEL103E001EA
Propidium iodide(PI)/RNase staining solution	Cell Signaling Technology Inc.	4087
Polybrene (hexadimethrine bromide)	MilliporeSigma	107687
Y-27632 ROCK inhibitor	MilliporeSigma	SCM075
Retinol	Sigma	R7632
Critical commercial assays
Aurum Total RNA Mini Kit	Bio-Rad	7326820
PureLink RNA Mini Kit	Thermo Fisher Scientific	12183020
iScript cDNA synthesis kit	Bio-Rad	1708890
High-Capacity cDNA Reverse Transcription Kit with RNase Inhibitor	Thermo Fisher Scientific	4374966
SsoAdvanced Universal SYBR Green Supermix	Bio-Rad	1725272
TaqMan Fast Advanced Master Mix	Thermo Fisher Scientific	4444556
Seahorse XF Cell Mito Stress Test Kit	Agilent	103015-100
PierceTM BCA protein assay	Thermo Fisher Scientific	23227
Deposited data
Raw and analyzed transcriptomic data	This paper	GEO: GSE108674
Experimental models: Cell lines
Normal human epidermal keratinocytes (NHEK)	PromoCell	12003
Normal human epidermal keratinocytes (NHEK)	Lonza	192627
Normal human epidermal keratinocytes (NHEK)	Thermo Fisher Scientific	C0055C
Normal human foreskin keratinocytes (reconstructed epidermis)	Episkin	N/A
Human: HaCaT	Addexbio	T0020001
Human: HEK 293T	ATCC	CRL-3216
Software and algorithms
DAVID Bioinformatics	Huang et al.71; Sherman et al.72	SCR_001881
Gene Ontology	Ashburner et al.73; Gene Ontology Consortium74	SCR_002811
R Project for Statistical Computing, R Bioconductor	R Foundation for Statistical Computing, (R Development Core Team, 2019)	SCR_001905 SCR_006442
GeneOverlap v.1.34.0	Shen Lab	http://shenlab-sinai.github.io/shenlab-sinai/
Pscan	Zambelli et al.75	http://159.149.160.88/pscan/
Gene Set Enrichment Analysis (GSEA)	Mootha et al.76; Subramanian et al.77	SCR_003199
CytoScape	Shannon et al.78	SCR_003032
Enrichment Map	Merico et al.79	N/A
Genotype-Tissue Expression (GTEX)	NIH Common Fund	SCR_013042
Correction for naturally occurring isotopes in-house JAVA program	Nanchen et al.80; McGuirk et al.81	N/A
FACSDivaTM software	BD Biosciences	SCR_001456
ImageScope software	Leica Biosystems	SCR_014311
Chemstation software	Agilent	SCR_015742