Abstract
The effect of papain treatment on the cartilage tissue of the knee joint of mature rabbits was studied by histological and thermoanalytical methods. Changes taking place in the composition of cartilage in the course of ageing were shown. As a result of papain treatment a significant irreversible destruction of the ground substance took place. Papain-induced loss of proteoglycans and the intensity of repair reactions and age-related differences are discussed.
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Selected References
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- Bentley G. Papain-induced degenerative arthritis of the hip in rabbits. J Bone Joint Surg Br. 1971 May;53(2):324–337. [PubMed] [Google Scholar]
- Bihari-Varga M. Thermoanalytical assay of glycosaminoglycans. Acta Biochim Biophys Acad Sci Hung. 1971;6(3):271–275. [PubMed] [Google Scholar]
- Farkas T., Bihari-Varga M., Biró T. Thermoanalytical and histological study of intra-articular papain-induced degradation and repair of rabbit cartilage. I. Immature animals. Ann Rheum Dis. 1974 Jul;33(4):385–390. doi: 10.1136/ard.33.4.385. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gardner D. L. The Experimental Production of Arthritis: A Review. Ann Rheum Dis. 1960 Dec;19(4):297–317. doi: 10.1136/ard.19.4.297. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mankin H. J. Biochemical and metabolic abnormalities in osteoarthritic human cartilage. Fed Proc. 1973 Apr;32(4):1478–1480. [PubMed] [Google Scholar]



