Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1977 Apr;36(2):157–159. doi: 10.1136/ard.36.2.157

Correlation between levels of DNA antibodies and clinical disease activity in SLE.

P Davis, J S Percy, A S Russell
PMCID: PMC1006651  PMID: 857742

Abstract

Sera were tested from 23 patients with systemic lupus erythematosus followed over a period of 1 to 5 years. Antibodies to native DNA were measured and correlated retrospectively with clinical evidence of disease activity. The overall degree of correlation between the presence of DNA antibodies and evidence of disease activity was good (P less than 0-001). Of 206 sera tested, only 4 had a normal DNA antibody at a time when significant clinical activity was noted. In contrast, 34 sera had mild to moderately raised DNA antibody levels at times of clinical remission. Although DNA antibodies are a useful investigation in the monitoring of disease activity, changes in therapy should not necessarily be made on DNA antibody levels alone.

Full text

PDF
157

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aarden L. A., Lakmaker F., de Groot E. R., Swaak A. J., Feltkamp T. E. Detection of antibodies to DNA by radioimmunoassay and immunofluorescence. Scand J Rheumatol Suppl. 1975;11:12–19. doi: 10.3109/03009747509095624. [DOI] [PubMed] [Google Scholar]
  2. Bell C., Talal N., Schur P. H. Antibodies to DNA in patients with rheumatoid arthritis and juvenile rheumatoid arthritis. Arthritis Rheum. 1975 Nov-Dec;18(6):535–540. doi: 10.1002/art.1780180602. [DOI] [PubMed] [Google Scholar]
  3. Davis P., Atkins B., Hughes G. R. Antibodies to native DNA in discoid lupus erythematosus. Br J Dermatol. 1974 Aug;91(2):175–181. doi: 10.1111/j.1365-2133.1974.tb15863.x. [DOI] [PubMed] [Google Scholar]
  4. Davis P., Read A. E. Antibodies to double-stranded (native) DNA in active chronic hepatitis. Gut. 1975 Jun;16(6):413–415. doi: 10.1136/gut.16.6.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ginsberg B., Keiser H. A Millipore filter assay for antibodies to native DNA in sera of patients with systemic lupus erythematosus. Arthritis Rheum. 1973 Mar-Apr;16(2):199–207. doi: 10.1002/art.1780160210. [DOI] [PubMed] [Google Scholar]
  6. Koffler D., Carr R., Agnello V., Thoburn R., Kunkel H. G. Antibodies to polynucleotides in human sera: antigenic specificity and relation to disease. J Exp Med. 1971 Jul 1;134(1):294–312. doi: 10.1084/jem.134.1.294. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Koffler D. Immunopathogenesis of systemic lupus erythematosus. Annu Rev Med. 1974;25:149–164. doi: 10.1146/annurev.me.25.020174.001053. [DOI] [PubMed] [Google Scholar]
  8. Lightfoot R. W., Redecha P. B., Levesanos N. Longitudinal studies of anti-DNA antibody levels in SLE. Scand J Rheumatol Suppl. 1975;11:52–58. doi: 10.3109/03009747509095629. [DOI] [PubMed] [Google Scholar]
  9. McGhee J. D., von Hippel P. H. Formaldehyde as a probe of DNA structure. I. Reaction with exocyclic amino groups of DNA bases. Biochemistry. 1975 Mar 25;14(6):1281–1296. doi: 10.1021/bi00677a029. [DOI] [PubMed] [Google Scholar]
  10. Morgan A. R., Pulleyblank D. E. Native and denatured DNA, cross-linked and palindromic DNA and circular covalently-closed DNA analysed by a sensitive fluorometric procedure. Biochem Biophys Res Commun. 1974 Nov 27;61(2):396–403. doi: 10.1016/0006-291x(74)90970-x. [DOI] [PubMed] [Google Scholar]
  11. Riggs A. D., Suzuki H., Bourgeois S. Lac repressor-operator interaction. I. Equilibrium studies. J Mol Biol. 1970 Feb 28;48(1):67–83. doi: 10.1016/0022-2836(70)90219-6. [DOI] [PubMed] [Google Scholar]
  12. Russell A. S., Percy J. S. The antigenicity of polynucleotides in mink, rabbit, and man. J Rheumatol. 1974 Mar;1(1):66–73. [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES