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. 1977 Apr;36(2):181–185. doi: 10.1136/ard.36.2.181

Role of ineffective erythropoiesis in the anaemia of rheumatoid arthritis.

D Samson, D Halliday, J M Gumpel
PMCID: PMC1006656  PMID: 857744

Abstract

The importance of inadequate haemoglobin synthesis and ineffective erythropoiesis in the anaemia of rheumatoid arthritis was studied by measuring the incorporation of 15N glycine into haemoglobin haem and early labelled bilirubin in a patient with severe anaemia before and after response to gold therapy. Initially, total erythroid haem turnover was decreased but haem turnover due to ineffective erythropoiesis was markedly increased, accounting for 29% of total erythroid haem turnover. Gold therapy resulted in marked clinical improvement, accompanied by a rise in haemoglobin to normal. Total erythroid haem turnover increased and the percentage ineffective erythropoiesis fell to normal. Ineffective erythropoiesis may thus be an important reversible factor in the production of the anaemia of rheumatoid arthritis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beamish M. R., Davies A. G., Eakins J. D., Jacobs A., Trevett D. The measurement of reticuloendothelial iron release using iron-dextran. Br J Haematol. 1971 Dec;21(6):617–622. doi: 10.1111/j.1365-2141.1971.tb02724.x. [DOI] [PubMed] [Google Scholar]
  2. Bennett R. M., Holt P. J., Lewis S. M. Role of the reticuloendothelial system in the anaemia of rheumatoid arthritis. A study using the 59Fe-labelled dextran model. Ann Rheum Dis. 1974 Mar;33(2):147–152. doi: 10.1136/ard.33.2.147. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cartwright G. E. The anemia of chronic disorders. Semin Hematol. 1966 Oct;3(4):351–375. [PubMed] [Google Scholar]
  4. FREIREICH E. J., ROSS J. F., BAYLES T. B., EMERSON C. P., FINCH S. C. Radioactive iron metabolism and erythrocyte survival studies of the mechanism of the anemia associated with rheumatoid arthritis. J Clin Invest. 1957 Jul;36(7):1043–1058. doi: 10.1172/JCI103500. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. GRAY C. H., SCOTT J. J. The effect of haemorrhage on the incorporation of [alpha-14C]Glycine into stercobilin. Biochem J. 1959 Jan;71(1):38–42. doi: 10.1042/bj0710038. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HAURANI F. I., BURKE W., MARTINEZ E. J. DEFECTIVE REUTILIZATION OF IRON IN THE ANEMIA OF INFLAMMATION. J Lab Clin Med. 1965 Apr;65:560–570. [PubMed] [Google Scholar]
  7. JEFFREY M. R. Some observations on anemia in rheumatoid arthritis. Blood. 1953 Jun;8(6):502–518. [PubMed] [Google Scholar]
  8. LABBE R. F., NISHIDA G. A new method of hemin isolation. Biochim Biophys Acta. 1957 Nov;26(2):437–437. doi: 10.1016/0006-3002(57)90033-1. [DOI] [PubMed] [Google Scholar]
  9. Lawson A. A., Owen E. T., Mowat A. G. Nature of anaemia in rheumatoid arthritis. VII. Storage of iron in rheumatoid disease. Ann Rheum Dis. 1967 Nov;26(6):552–559. doi: 10.1136/ard.26.6.552. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Mowat A. G. Hematologic abnormalities in rheumatoid arthritis. Semin Arthritis Rheum. 1972 Winter;1(3):195–219. doi: 10.1016/0049-0172(72)90001-7. [DOI] [PubMed] [Google Scholar]
  11. ROBERTS F. D., HAGEDORN A. B., SLOCUMB C. H., OWEN C. A. Evaluation of the anemia of rheumatoid arthritis. Blood. 1963 Apr;21:470–478. [PubMed] [Google Scholar]
  12. Samson D., Halliday D., Nicholson D. C., Chanarin I. Quantitation of ineffective erythropoiesis from the incorporation of [15N] delta-aminolaevulinic acid and [15N] glycin into early labelled bilirubin. II. Anaemic patients. Br J Haematol. 1976 Sep;34(1):45–53. doi: 10.1111/j.1365-2141.1976.tb00172.x. [DOI] [PubMed] [Google Scholar]
  13. Samson D., Halliday D., Nicholson D. C., Chanarin I. Quantitation of ineffective erythropoiesis from the incorporation of [15N] delta-aminolaevulinic acid and [15N] glycine into early labelled bilirubin. I. Normal subjects. Br J Haematol. 1976 Sep;34(1):33–44. doi: 10.1111/j.1365-2141.1976.tb00171.x. [DOI] [PubMed] [Google Scholar]
  14. WEINSTEIN I. M. A correlative study of the erythrokinetics and disturbances in iron metabolism associated with the anemia of rheumatoid arthritis. Blood. 1959 Aug;14(8):950–966. [PubMed] [Google Scholar]

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