Abstract
Eighteen patients with polymyalgia rheumatica had corticosteroid treatment withdrawn abruptly under close observation. In each case polymyalgic symptoms reappeared but were controlled rapidly when prednisolone was reintroduced. Prednisolone withdrawal was then started by slow decrements of dose. In no patient was it possible to withdraw prednisolone treatment, after using either method, during the period of observation.
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Selected References
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- Ackerman G. L., Nolsn C. M. Adrenocortical responsiveness after alternate-day corticosteroid therapy. N Engl J Med. 1968 Feb 22;278(8):405–409. doi: 10.1056/NEJM196802222780801. [DOI] [PubMed] [Google Scholar]
- BAGRATUNI L. Prognosis in the anarthritic rheumatoid syndrome. Br Med J. 1963 Feb 23;1(5329):513–518. doi: 10.1136/bmj.1.5329.513. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bacon P. A., Myles A. B., Beardwell C. G., Daly J. R. Corticosteroid withdrawal in rheumatoid arthritis. Lancet. 1966 Oct 29;2(7470):935–937. doi: 10.1016/s0140-6736(66)90537-x. [DOI] [PubMed] [Google Scholar]
- Bruk M. I. Articular and vascular manifestations of polymyalgia rheumatica. Ann Rheum Dis. 1967 Mar;26(2):103–116. doi: 10.1136/ard.26.2.103. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carter M. E., James V. H. Effect of alternate-day, single-dose, corticosteroid therapy on pituitary-adrenal function. Ann Rheum Dis. 1972 Sep;31(5):379–383. doi: 10.1136/ard.31.5.379. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dixon A. S., Beardwell C., Kay A., Wanka J., Wong Y. T. Polymyalgia rheumatica and temporal arteritis. Ann Rheum Dis. 1966 May;25(3):203–208. doi: 10.1136/ard.25.3.203. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Easterbrook W. M., Baxter D. W., Martin J. R. Temporal arteritis developing during indomethacin therapy of polymyalgia rheumatica. Can Med Assoc J. 1967 Aug 5;97(6):296–299. [PMC free article] [PubMed] [Google Scholar]
- Floyd M., Muckle T. J., Kerr D. N. Prednisone-induced leucocytosis in nephrotic syndrome. Lancet. 1969 Jun 14;1(7607):1192–1193. doi: 10.1016/s0140-6736(69)92170-9. [DOI] [PubMed] [Google Scholar]
- GOOD T. A., BENTON J. W., KELLEY V. C. Symptomatology resulting from withdrawal of steroid hormone therapy. Arthritis Rheum. 1959 Aug;2:299–321. doi: 10.1002/1529-0131(195908)2:4<299::aid-art1780020403>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
- GORDON I. Polymyalgia rheumatica. A clinical study of 21 cases. Q J Med. 1960 Oct;29:473–488. [PubMed] [Google Scholar]
- Glick E. N. Raised serum-alkaline-phosphatase levels in polymyalgia rheumatica. Lancet. 1972 Aug 12;2(7772):328–328. doi: 10.1016/s0140-6736(72)92932-7. [DOI] [PubMed] [Google Scholar]
- HEPTINSTALL R. H., PORTER K. A., BARKLEY H. Giant-cell (temporal) arteritis. J Pathol Bacteriol. 1954 Apr;67(2):507–519. doi: 10.1002/path.1700670224. [DOI] [PubMed] [Google Scholar]
- Hall G. H., Hargreaves T. Giant-cell arteritis and raised serum-alkaline-phosphatase levels. Lancet. 1972 Jul 1;2(7766):48–48. doi: 10.1016/s0140-6736(72)91310-4. [DOI] [PubMed] [Google Scholar]
- Hamilton C. R., Jr, Shelley W. M., Tumulty P. A. Giant cell arteritis: including temporal arteritis and polymyalgia rheumatica. Medicine (Baltimore) 1971 Jan;50(1):1–27. [PubMed] [Google Scholar]
- Hargreave F. E., McCarthy D. S., Pepys J. Steroid "pseudorheumatism" in asthma. Br Med J. 1969 Feb 15;1(5641):443–444. doi: 10.1136/bmj.1.5641.443-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hunder G. G., Sheps S. G., Allen G. L., Joyce J. W. Daily and alternate-day corticosteroid regimens in treatment of giant cell arteritis: comparison in a prospective study. Ann Intern Med. 1975 May;82(5):613–618. doi: 10.7326/0003-4819-82-5-613. [DOI] [PubMed] [Google Scholar]
- Livanou T., Ferriman D., James V. H. Recovery of hypothalamo-pituitary-adrenal function after corticosteroid therapy. Lancet. 1967 Oct 21;2(7521):856–859. doi: 10.1016/s0140-6736(67)92592-5. [DOI] [PubMed] [Google Scholar]
- MacGregor R. R., Sheagren J. N., Lipsett M. B., Wolff S. M. Alternate-day prednisone therapy. Evaluation of delayed hypersensitivity responses, control of disease and steroid side effects. N Engl J Med. 1969 Jun 26;280(26):1427–1431. doi: 10.1056/NEJM196906262802601. [DOI] [PubMed] [Google Scholar]
- Mowat A. G., Hazleman B. L. Polymyalgia rheumatica -- a clinical study with particular reference to arterial disease. J Rheumatol. 1974 Jun;1(2):190–202. [PubMed] [Google Scholar]
- NELSON D. H., SANDBERG A. A., PALMER J. G., TYLER F. H. Blood levels of 17-hydroxycorticosteroids following the administration of adrenal steroids and their relation to levels of circulating leukocytes. J Clin Invest. 1952 May;31(9):843–849. doi: 10.1172/JCI102671. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PALMER H. P., MICHAEL I. E. GIANT-CELL MYOCARDITIS WITH MULTIPLE ORGAN INVOLVEMENT. Arch Intern Med. 1965 Sep;116:444–447. doi: 10.1001/archinte.1965.03870030124022. [DOI] [PubMed] [Google Scholar]
- PAULLEY J. W., HUGHES J. P. Giant-cell arteritis, or arteritis of the aged. Br Med J. 1960 Nov 26;2(5212):1562–1567. doi: 10.1136/bmj.2.5212.1562. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Paulsen S., Iversen T. O. Rheumatic polymyalgia. Long-term treatment with steroids. Acta Rheumatol Scand. 1971;17(3):165–168. doi: 10.3109/rhe1.1971.17.issue-1-4.22. [DOI] [PubMed] [Google Scholar]
- ROBINSON B. H., MATTINGLY D., COPE C. L. Adrenal function after prolonged corticosteroid therapy. Br Med J. 1962 Jun 9;1(5292):1579–1584. doi: 10.1136/bmj.1.5292.1579. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Siegel R. R., Luke R. G., Hellebusch A. A. Reduction of toxicity of corticosteroid therapy after renal transplantation. Am J Med. 1972 Aug;53(2):159–169. doi: 10.1016/0002-9343(72)90126-x. [DOI] [PubMed] [Google Scholar]
- Wadman B., Werner I. Therapeutic hazards of phenylbutazone and oxyphenbutazone in polymyalgia rheumatica. Lancet. 1967 Mar 18;1(7490):597–598. doi: 10.1016/s0140-6736(67)90444-8. [DOI] [PubMed] [Google Scholar]