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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1977 Jun;36(3):239–243. doi: 10.1136/ard.36.3.239

Action of nonsteroidal, anti-inflammatory drugs on human and rat peripheral leucocyte migration in vitro.

K A Brown, A J Collins
PMCID: PMC1006672  PMID: 301730

Abstract

Using an in vitro system of cell migration from glass capillary tubes, the nonsteroidal, anti-inflammatory agents sodium salicylate, aspirin, ibuprofen, phenylbutazone, and indomethacin were shown to inhibit the migration of human peripheral leucocytes in a dose-related manner. This drug action was not confined to one species, as shown by the modification of rat peripheral leucocyte motility by sodium salicylate and aspirin. The relevance of the human findings to the clinical effectiveness of these agents is discussed.

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Selected References

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