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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1977 Aug;36(4):381–382. doi: 10.1136/ard.36.4.381

Effect of excising Freund's adjuvant granuloma on subsequent development of experimental allergic arthritis.

D Hirschowitz, A Fox, L E Glynn
PMCID: PMC1006703  PMID: 901038

Abstract

Rabbits were immunized with antigen in Freund's complete adjuvant. Several weeks later the granuloma which developed was excised one day before joint challenge with antigen. The subsequent development of experimental allergic arthritis (EAA) was not affected, which argues against the chronicity of the disease being maintained by continuous recruitment of mycobacterial debris to EAA joints.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Consden R., Doble A., Glynn L. E., Nind A. P. Production of a chronic arthritis with ovalbumin. Its retention in the rabbit knee joint. Ann Rheum Dis. 1971 May;30(3):307–315. doi: 10.1136/ard.30.3.307. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. DUMONDE D. C., GLYNN L. E. The production of arthritis in rabbits by an immunological reaction to fibrin. Br J Exp Pathol. 1962 Aug;43:373–383. [PMC free article] [PubMed] [Google Scholar]
  3. Doble A., Fox A., Glynn L. E., Kingston D. The non-passage of mycobacteria from Freund's complete adjuvant granuloma depots to arthritic joints. Br J Exp Pathol. 1975 Dec;56(6):537–543. [PMC free article] [PubMed] [Google Scholar]
  4. WARD J. R., JONES R. S. Studies on adjuvant-induced polyarthritis in rats. I. Adjuvant composition, route of injection, and removal of depot site. Arthritis Rheum. 1962 Dec;5:557–564. doi: 10.1002/art.1780050604. [DOI] [PubMed] [Google Scholar]

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