Skip to main content
JCI Insight logoLink to JCI Insight
. 2023 Mar 22;8(6):e169756. doi: 10.1172/jci.insight.169756

Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

Tomonori Tadokoro, Masataka Ikeda, Tomomi Ide, Hiroko Deguchi, Soichiro Ikeda, Kosuke Okabe, Akihito Ishikita, Shouji Matsushima, Tomoko Koumura, Ken-ichi Yamada, Hirotaka Imai, Hiroyuki Tsutsui
PMCID: PMC10070098  PMID: 36946465

Abstract

graphic file with name jciinsight-8-169756-g226.jpg


Original citation: JCI Insight. 2020;5(9):e132747. https://doi.org/10.1172/jci.insight.132747

Citation for this corrigendum: JCI Insight. 2023;8(6):e169756. https://doi.org/10.1172/jci.insight.169756

The authors recently became aware that the Mito-FerroGreen (MFG) used in this study is not an Fe2+ chelator, but instead reduces Fe2+ via conversion to Fe3+. As MFG mediates reduction of Fe2+ and suppresses ferroptosis, the overall conclusions are not affected. For clarity, the authors have removed references to MFG-mediated chelation throughout, updated the Graphical Abstract, and renumbered the reference list to refer to Hirayama et al. (1) when first describing the use of MFG in the Results section. The text and Graphical Abstract have been updated in the HTML version and PDF. The Journal has also published an online version of the original article with the incorrect statements crossed out and the modified text printed in red (Supplemental File, Redaction).

The authors regret the errors.

Supplementary Material

redacted article

Version 1. 03/22/2023

Electronic publication

Footnotes

References

  • 1.Hirayama T, et al. A mitochondria-targeted fluorescent probe for selective detection of mitochondrial labile Fe(ii) Metallomics. 2018;10(6):794–801. doi: 10.1039/C8MT00049B. [DOI] [PubMed] [Google Scholar]

Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

redacted article

Articles from JCI Insight are provided here courtesy of American Society for Clinical Investigation

RESOURCES