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. 2023 Apr 5;29(6):549–555. doi: 10.1007/s11655-023-3733-2

Therapeutic Application, Phytoactives and Pharmacology of Tinospora cordifolia: An Evocative Review

Rabiya Ahsan 1, Anuradha Mishra 2,✉, Badruddeen Badar 1, Mohammad Owais 1, Vijayshwari Mishra 3
PMCID: PMC10073789  PMID: 37017881

Abstract

Tinospora cordifolia (Guduchi or Gurjo), a herbaceous vine or climbing deciduous shrub, is consider as an important medicine in the Ayurvedic system of medication, which is available in India, China, Myanmar, Bangladesh and Srilanka. Menispermaceae is the family of this compound. T. cordifolia have a variety of properties to treat various ailments such as fevers, jaundice, diabetes, dysentery, urinary infections, and skin diseases. This compound has been subjected to many chemicals, pharmacological, pre-clinical, or clinical investigations and some new therapeutic potential effects have been indicated. This review aims to summarize the critical information concerning in areas of chemical constituents, chemical structure, and pharmacokinetic activities such as anti-diabetic, anticancer, immune-modulatory, antivirus (especially in silico study about COVID-19), antioxidant, antimicrobial, hepatoprotective and its effect on cardiovascular and neurological disorders as well as rheumatoid arthritis. This traditional herb needs more experimental study on the clinical, pre-clinical study, and clinical efficacy of these compounds for the prevention and treatment of COVID-19 and needs large-scale clinical studies to prove the clinical efficacy of this compound, especially in stress-related diseases and other neuronal disorders.

Keywords: Tinospora cordifolia, Guduchi, menispermaceae, pharmacology

Acknowledgment

Author is thankful to Integral University Lucknow for providing manuscript number IU/R&D/2022-MCN0001444.

Author Contribution

Ahsan R and Mishra A conceived and Badar B modified this manuscript, Ahsan R, Owais M and Mishra V have collected the literature. Ahsan R wrote the manuscript. Reviewers helped to revise the manuscript. All authors read and approved the manuscript.

Footnotes

Conflict of Interest

The authors declare no potential conflicts of interest concerning the review, authorship, and/or publication of this article.

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