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. 1976 Aug;35(4):339–343. doi: 10.1136/ard.35.4.339

Effects of enzyme induction on metabolism of prednisolone. Clinical and laboratory study.

P M Brooks, W W Buchanan, M Grove, W W Downie
PMCID: PMC1007392  PMID: 970991

Abstract

The addition of phenobarbitone in therapeutic dosage to the drug regimen of prednisolone-treated subjects with rheumatoid arthritis produced measurable deterioration in the clinical status of the patients associated with a more rapid clearance of prednisolone from plasma. It is considered that phenobarbitone induced the hepatic metabolism of prednisolone, effectively reducing the steady state plasma level and resulting in clinical relapse. A slight but significant improvement in the adrenocortical response to tetracosactrin (Synacthen) was noted after phenobarbitone therapy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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