Multinucleation resets human macrophages for specialized functions at the expense of their identity

Abstract

By mutual agreement of all authors and based on the author contribution statement, Graham R Williams and J H Duncan Bassett are added to this manuscript.

The authorship is corrected from:

Kourosh Ahmadzadeh^1,†, Marie Pereira^2,†, Margot Vanoppen¹, Eline Bernaerts¹, Jeong‐Hun Ko², Tania Mitera¹, Christy Maksoudian³, Bella B Manshian⁴, Stefaan Soenen³, Carlos D Rose⁵, Patrick Matthys^1,†, Carine Wouters,^1,6,7,† and Jacques Behmoaras^2,8

†, equal contribution

¹Laboratory of Immunobiology, Department Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven—University of Leuven, Leuven, Belgium

²Centre for Inflammatory Disease, Department of Immunology and Inflammation, Hammersmith Hospital, Imperial College London, Du Cane Road W12 0NN, London, UK

³NanoHealth and Optical Imaging Group, Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000 Leuven, Belgium

⁴Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000 Leuven, Belgium

⁵Division of Pediatric Rheumatology Nemours Children's Hospital, Thomas Jefferson University, Philadelphia, United States of America

⁶Division Pediatric Rheumatology, UZ Leuven, Leuven, Belgium

⁷European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) at University Hospital Leuven, Leuven, Belgium

⁸Programme in Cardiovascular and Metabolic Disorders and Centre for Computational Biology, Duke‐NUS Medical School Singapore, Singapore

To (See additions in bold):

Kourosh Ahmadzadeh^1,†, Marie Pereira^2,†, Margot Vanoppen¹, Eline Bernaerts¹, Jeong‐Hun Ko², Tania Mitera¹, Christy Maksoudian³, Bella B Manshian⁴, Stefaan Soenen³, Carlos D Rose⁵, Graham R Williams ^6,* , JH Duncan Bassett ^6,** , Patrick Matthys^{1,*** ,†}, Carine Wouters^{1,7,8,**** ,†} & Jacques Behmoaras^2,9,*****

¹Laboratory of Immunobiology, Department Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven—University of Leuven, Leuven, Belgium

²Centre for Inflammatory Disease, Department of Immunology and Inflammation, Hammersmith Hospital, Imperial College London, London, UK

³NanoHealth and Optical Imaging Group, Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium

⁴Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium

⁵Division of Pediatric Rheumatology Nemours Children's Hospital, Thomas Jefferson University, Philadelphia, PA, USA

⁶Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

⁷Division Pediatric Rheumatology, UZ Leuven, Leuven, Belgium

⁸European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) at University Hospital Leuven, Leuven, Belgium

⁹Programme in Cardiovascular and Metabolic Disorders and Centre for Computational Biology, Duke‐NUS Medical School Singapore, Singapore, Singapore

*Corresponding author. Tel: +442083831383: E‐mail: graham.williams@imperial.ac.uk

**Corresponding author. Tel: +442083834613: E‐mail: d.bassett@imperial.ac.uk

***Corresponding author. Tel: +32497122503: E‐mail: patrick.matthys@kuleuven.be

****Corresponding author. Tel: +32475415459: E‐mail: carine.wouters@uzleuven.be

*****Corresponding author. Tel: +6566011137: E‐mail: jacquesb@duke-nus.edu.sg

^†These authors contributed equally to this work

Author contributions (added to the “Author Contribution” section)

Graham R Williams: Conceptualization; analysis; supervision; funding acquisition; project administration; writing‐review and approval.

JH Duncan Bassett: Conceptualization; analysis; supervision; funding acquisition; project administration; writing‐review and approval.

Author statement

Contribution to the study and justification for corresponding authorship.

Substantial contributions to the conception or design of the work (Profs Williams and Bassett are co‐applicants on the MRC grant that funded this work, and they conceived, designed, and co‐supervised the osteoclast FACS sorting and RNAseq experiments together with Dr Behmoaras).

Acquisition, analysis, and interpretation of data for the work.

Revising the work critically for important intellectual content.

Final approval of the version to be published.

Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.