Abstract
The mortality of over 1250 male and 420 female asbestos factory workers was observed over the period 1971-80. Smoking habits were obtained from the subjects in 1971 before the start of the follow up period. Mortality due to lung cancer and to mesothelioma was related to smoking habits. After allowing for the effect of smoking on lung cancer the relative risk due to asbestos was highest for those who had never smoked, lowest for current smokers, and intermediate for ex-smokers; the trend was statistically significant (p less than 0.05). There was no significant association between smoking and deaths due to mesothelioma. Data from several studies are reviewed, and although overall non-smokers have a relative risk of lung cancer due to asbestos that is 1.8 times that of smokers, there is some uncertainty on the accuracy of this figure because of possible biases and sampling variation. Overall the evidence is that mesothelioma risk is independent of smoking.
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Selected References
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- Berry G., Newhouse M. L., Turok M. Combined effect of asbestos exposure and smoking on mortality from lung cancer in factory workers. Lancet. 1972 Sep 2;2(7775):476–478. doi: 10.1016/s0140-6736(72)91867-3. [DOI] [PubMed] [Google Scholar]
- Berry G. The analysis of mortality by the subject-years method. Biometrics. 1983 Mar;39(1):173–184. [PubMed] [Google Scholar]
- CASE R. A., LEA A. J. Mustard gas poisoning, chronic bronchitis, and lung cancer; an investigation into the possibility that poisoning by mustard gas in the 1914-18 war might be a factor in the production of neoplasia. Br J Prev Soc Med. 1955 Apr;9(2):62–72. doi: 10.1136/jech.9.2.62. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Doll R., Gray R., Hafner B., Peto R. Mortality in relation to smoking: 22 years' observations on female British doctors. Br Med J. 1980 Apr 5;280(6219):967–971. doi: 10.1136/bmj.280.6219.967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Doll R., Peto R. Mortality in relation to smoking: 20 years' observations on male British doctors. Br Med J. 1976 Dec 25;2(6051):1525–1536. doi: 10.1136/bmj.2.6051.1525. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hammond E. C., Selikoff I. J., Seidman H. Asbestos exposure, cigarette smoking and death rates. Ann N Y Acad Sci. 1979;330:473–490. doi: 10.1111/j.1749-6632.1979.tb18749.x. [DOI] [PubMed] [Google Scholar]
- McDonald A. D., McDonald J. C. Malignant mesothelioma in North America. Cancer. 1980 Oct 1;46(7):1650–1656. doi: 10.1002/1097-0142(19801001)46:7<1650::aid-cncr2820460726>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
- McDonald J. C., Liddell F. D., Gibbs G. W., Eyssen G. E., McDonald A. D. Dust exposure and mortality in chrysotile mining, 1910-75. Br J Ind Med. 1980 Feb;37(1):11–24. doi: 10.1136/oem.37.1.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Saracci R. Asbestos and lung cancer: an analysis of the epidemiological evidence on the asbestos-smoking interaction. Int J Cancer. 1977 Sep 15;20(3):323–331. doi: 10.1002/ijc.2910200302. [DOI] [PubMed] [Google Scholar]
- Selikoff I. J., Hammond E. C. Asbestos and smoking. JAMA. 1979 Aug 3;242(5):458–459. [PubMed] [Google Scholar]
- Selikoff I. J., Seidman H., Hammond E. C. Mortality effects of cigarette smoking among amosite asbestos factory workers. J Natl Cancer Inst. 1980 Sep;65(3):507–513. [PubMed] [Google Scholar]