Figure 2. Example of a TMM-, Nonrecanalized Patient.

(A) An 8-year-old girl presented within 3.5 hours of last known well with right MCA-M1 occlusion, NIHSS 8. (B) TMM criteria were not met using either Tmax>6 or Tmax>4 penumbral thresholds. Core infarct of 29 mL defined by ADC< 620 × 10⁻⁶ mm²/s. (C) mTICI 1 (unsuccessful) reperfusion. (D) Final stroke volume was 25.6 mL (consistent with absent penumbra on initial RAPID maps); parenchymal hemorrhage (PH2) noted in the stroke bed. mRS 3 at 6-month follow-up. Abbreviations: ADC = apparent diffusion coefficient; mRS = modified Rankin Scale; mTICI = modified treatment in cerebral infarction; Tmax = time to maximum tissue residue function; TMM = target mismatch.