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. 1986 Mar;43(3):188–191. doi: 10.1136/oem.43.3.188

Spirometric data and penetration of particles to the alveoli.

M Svartengren, E Hassler, K Philipson, P Camner
PMCID: PMC1007631  PMID: 3947582

Abstract

The percentage retention at 24 hours of 4 micron Teflon particles, aerodynamic diameter about 6 micron, was studied in 29 healthy male volunteers. The particles were inhaled at 0.5l/s with maximally deep breaths. The 24 hour retention correlated significantly with FEV1 and FVC and persisted when the subjects were divided into different categories according to profession and smoking habits. The results suggest that for exposure to metal particles at a size where impaction is an important deposition mechanism--that is, particles larger than a few microns--workers with large FEV1 values may run a greater risk of receiving systemic toxic effects than those with small FEV1 values.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Agnew J. E., Pavia D., Clarke S. W. Airways penetration of inhaled radioaerosol: an index to small airways function? Eur J Respir Dis. 1981 Aug;62(4):239–255. [PubMed] [Google Scholar]
  2. BERGLUND E., BIRATH G., BJURE J., GRIMBY G., KJELLMER I., SANDQVIST L., SODERHOLM B. Spirometric studies in normal subjects. I. Forced expirograms in subjects between 7 and 70 years of age. Acta Med Scand. 1963 Feb;173:185–192. [PubMed] [Google Scholar]
  3. Bailey M. R., Fry F. A., James A. C. The long-term clearance kinetics of insoluble particles from the human lung. Ann Occup Hyg. 1982;26(1-4):273–290. [PubMed] [Google Scholar]
  4. Bohning D. E., Atkins H. L., Cohn S. H. Long-term particle clearance in man: normal and impaired. Ann Occup Hyg. 1982;26(1-4):259–271. [PubMed] [Google Scholar]
  5. Camner P., Philipson K., Arvidsson T. Withdrawal of cigarette smoking: a study on tracheobronchial clearance. Arch Environ Health. 1973 Feb;26(2):90–92. doi: 10.1080/00039896.1973.10666231. [DOI] [PubMed] [Google Scholar]
  6. Camner P., Philipson K. Human alveolar deposition of 4 micron teflon particles. Arch Environ Health. 1978 Jul-Aug;33(4):181–185. doi: 10.1080/00039896.1978.10667331. [DOI] [PubMed] [Google Scholar]
  7. Camner P., Philipson K. Tracheobronchial clearance in smoking-discordant twins. Arch Environ Health. 1972 Jul;25(1):60–63. doi: 10.1080/00039896.1972.10666136. [DOI] [PubMed] [Google Scholar]
  8. Dolovich M. B., Sanchis J., Rossman C., Newhouse M. T. Aerosol penetrance: a sensitive index of peripheral airways obstruction. J Appl Physiol. 1976 Mar;40(3):468–471. doi: 10.1152/jappl.1976.40.3.468. [DOI] [PubMed] [Google Scholar]
  9. Goodman R. M., Yergin B. M., Landa J. F., Golivanux M. H., Sackner M. A. Relationship of smoking history and pulmonary function tests to tracheal mucous velocity in nonsmokers, young smokers, ex-smokers, and patients with chronic bronchitis. Am Rev Respir Dis. 1978 Feb;117(2):205–214. doi: 10.1164/arrd.1978.117.2.205. [DOI] [PubMed] [Google Scholar]
  10. Lundborg M., Lind B., Camner P. Ability of rabbit alveolar macrophages to dissolve metals. Exp Lung Res. 1984;7(1):11–22. doi: 10.3109/01902148409087905. [DOI] [PubMed] [Google Scholar]
  11. MORROW P. E., GIBB F. R., JOHNSON L. CLEARANCE OF INSOLUBLE DUST FROM THE LOWER RESPIRATORY TRACT. Health Phys. 1964 Aug;10:543–555. doi: 10.1097/00004032-196408000-00003. [DOI] [PubMed] [Google Scholar]
  12. Mercer T. T. On the role of particle size in the dissolution of lung burdens. Health Phys. 1967 Nov;13(11):1211–1221. doi: 10.1097/00004032-196711000-00005. [DOI] [PubMed] [Google Scholar]
  13. Morrow P. E., Gibb F. R., Gazioglu K. M. A study of particulate clearance from the human lungs. Am Rev Respir Dis. 1967 Dec;96(6):1209–1221. doi: 10.1164/arrd.1967.96.6.1209. [DOI] [PubMed] [Google Scholar]
  14. Pavia D., Thomson M. L., Clarke S. W., Shannon H. S. Effect of lung function and mode of inhalation on penetration of aerosol into the human lung. Thorax. 1977 Apr;32(2):194–197. doi: 10.1136/thx.32.2.194. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Pavia D., Thomson M., Shannon H. S. Aerosol inhalation and depth of deposition in the human lung. The effect of airway obstruction and tidal volume inhaled. Arch Environ Health. 1977 May-Jun;32(3):131–137. doi: 10.1080/00039896.1977.10667269. [DOI] [PubMed] [Google Scholar]
  16. Philipson K., Falk R., Camner P. Long-term lung clearance in humans studied with Teflon particles labeled with chromium-51. Exp Lung Res. 1985;9(1-2):31–42. doi: 10.3109/01902148509061526. [DOI] [PubMed] [Google Scholar]
  17. Puchelle E., Zahm J. M., Bertrand A. Influence of age on bronchial mucociliary transport. Scand J Respir Dis. 1979 Dec;60(6):307–313. [PubMed] [Google Scholar]
  18. Svartengren M., Widtskiöld-Olsson K., Philipson K., Camner P. Retention of particles on the first bifurcation and the trachea of rabbits. Bull Eur Physiopathol Respir. 1981 Jan-Feb;17(1):87–91. [PubMed] [Google Scholar]

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