Abstract
In the period 1966-82 lungs from 333 workers who had been employed at a Royal Naval dockyard were referred to the MRC Pneumoconiosis Unit where they were investigated for the severity of asbestosis, the presence of tumours, and an assessment of mineral fibre content and the type and amount of mineral present. The occupational exposure to mineral dust has been coded for 189 of these cases. There is good correlation between the severity of asbestosis and the coded exposures, electron microscopic mineral fibre count, and the fibre count as seen under the light microscope. The information collected showed that mesotheliomas occurred in those who had had minimal or slight asbestosis, by contrast with the pulmonary carcinomas found in those with moderate to severe asbestosis. The amphibole (crocidolite and amosite) lung content correlated with severity of asbestosis.
Full text
PDF![391](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee3/1007669/c1563f0cb218/brjindmed00170-0031.png)
![392](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee3/1007669/a05a4072e98d/brjindmed00170-0032.png)
![393](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee3/1007669/740fbf20c55e/brjindmed00170-0033.png)
![394](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee3/1007669/4720c06945ee/brjindmed00170-0034.png)
![395](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee3/1007669/fdb823791a39/brjindmed00170-0035.png)
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ashcroft T., Heppleston A. G. The optical and electron microscopic determination of pulmonary asbestos fibre concentration and its relation to the human pathological reaction. J Clin Pathol. 1973 Mar;26(3):224–234. doi: 10.1136/jcp.26.3.224. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harries P. G. Asbestos hazards in naval dockyards. Ann Occup Hyg. 1968 Apr;11(2):135–145. doi: 10.1093/annhyg/11.2.135. [DOI] [PubMed] [Google Scholar]
- Pooley F. D. The identification of asbestos dust with an electron microscope microprobe analyser. Ann Occup Hyg. 1975 Dec;18(3):181–186. doi: 10.1093/annhyg/18.3.181. [DOI] [PubMed] [Google Scholar]
- Seal R. M. Current views on pathological aspects of asbestosis (the unresolved questions and problems). IARC Sci Publ. 1980;(30):217–235. [PubMed] [Google Scholar]
- Wagner J. C., Pooley F. D., Berry G., Seal R. M., Munday D. E., Morgan J., Clark N. J. A pathological and mineralogical study of asbestos-related deaths in the United Kingdom in 1977. Ann Occup Hyg. 1982;26(1-4):423–431. [PubMed] [Google Scholar]
- Whitwell F., Scott J., Grimshaw M. Relationship between occupations and asbestos-fibre content of the lungs in patients with pleural mesothelioma, lung cancer, and other diseases. Thorax. 1977 Aug;32(4):377–386. doi: 10.1136/thx.32.4.377. [DOI] [PMC free article] [PubMed] [Google Scholar]