Abstract
A cross sectional study was conducted on workers engaged in manufacturing precious metal powder. Of the 27 workers, 96% had raised urine silver concentrations (range 0.5-52.0 micrograms/l, mean 11.3 micrograms/l) and 92% had raised blood silver concentrations (range 0.05-6.2 micrograms/100 ml, mean 1.0 microgram/100 ml). Nineteen per cent also had raised urine cadmium concentrations (range 1.9-76.0 micrograms/l, mean 11.8 micrograms/l). Most workers had symptoms of respiratory irritation and nose bleeds were reported in eight (30%) of the 27 workers. Deposition of silver in the cornea of the eye was detected in five of eight (63%) of the long term workers. Although not statistically significant, corneal deposition was associated with complaints of decreased night vision. The urinary enzyme N-acetyl-B-D glucosaminidase (NAG) was significantly raised in four individuals and was correlated with blood silver concentrations and age. In addition, the group's average NAG concentration was significantly higher than that found in a control population. No association between age and urinary NAG was found in the control group. Estimated creatinine clearance was also significantly lower in the group exposed to silver than in the control group. Kidney function appears to have been adversely affected by exposures at work but because of the exposure to cadmium the role of silver in causing the decrement in kidney function could not be definitely determined.
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- Alderman M. H., Melcher L., Drayer D. E., Reidenberg M. M. Increased excretion of urinary N-acetyl-beta-glucosaminidase in essential hypertension and its decline with antihypertensive therapy. N Engl J Med. 1983 Nov 17;309(20):1213–1217. doi: 10.1056/NEJM198311173092004. [DOI] [PubMed] [Google Scholar]
- Cockcroft D. W., Gault M. H. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31–41. doi: 10.1159/000180580. [DOI] [PubMed] [Google Scholar]
- Elinder C. G., Edling C., Lindberg E., Kågedal B., Vesterberg O. Assessment of renal function in workers previously exposed to cadmium. Br J Ind Med. 1985 Nov;42(11):754–760. doi: 10.1136/oem.42.11.754. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Falck F. Y., Jr, Fine L. J., Smith R. G., McClatchey K. D., Annesley T., England B., Schork A. M. Occupational cadmium exposure and renal status. Am J Ind Med. 1983;4(4):541–549. doi: 10.1002/ajim.4700040408. [DOI] [PubMed] [Google Scholar]
- Howlett C., Taylor A. Measurement of silver in blood by atomic-absorption spectrophotometry using the micro-cup technique. Analyst. 1978 Sep;103(1230):916–920. doi: 10.1039/an9780300916. [DOI] [PubMed] [Google Scholar]
- Meyer B. R., Fischbein A., Rosenman K., Lerman Y., Drayer D. E., Reidenberg M. M. Increased urinary enzyme excretion in workers exposed to nephrotoxic chemicals. Am J Med. 1984 Jun;76(6):989–998. doi: 10.1016/0002-9343(84)90847-7. [DOI] [PubMed] [Google Scholar]
- Moss A. P., Sugar A., Hargett N. A., Atkin A., Wolkstein M., Rosenman K. D. The ocular manifestations and functional effects of occupational argyrosis. Arch Ophthalmol. 1979 May;97(5):906–908. doi: 10.1001/archopht.1979.01020010464015. [DOI] [PubMed] [Google Scholar]
- PERRY H. M., Jr, PERRY E. F. Normal concentrations of some trace metals in human urine: changes produced by ethylenediaminetetraacetate. J Clin Invest. 1959 Aug;38(8):1452–1463. doi: 10.1172/JCI103922. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rosenman K. D., Moss A., Kon S. Argyria: clinical implications of exposure to silver nitrate and silver oxide. J Occup Med. 1979 Jun;21(6):430–435. [PubMed] [Google Scholar]
- Stonard M. D., Chater B. V., Duffield D. P., Nevitt A. L., O'Sullivan J. J., Steel G. T. An evaluation of renal function in workers occupationally exposed to mercury vapour. Int Arch Occup Environ Health. 1983;52(2):177–189. doi: 10.1007/BF00405421. [DOI] [PubMed] [Google Scholar]