Abstract
A group of 137 male workers with known exposure (mean 20 fibre years per millilitre) to asbestos cement who had symptoms or signs of pulmonary disease was studied together with a reference group of 49 healthy industrial workers with no exposure to asbestos. Lung function measurements were made at rest and during exercise. Evidence of lung fibrosis was found as well as of obstructive airways disease in the exposed group compared with the reference group. Asbestos cement exposure was related to variables reflecting lung fibrosis but not to variables reflecting airflow obstruction. Smoking was related to variables reflecting obstructive lung disease. Exercise capacity was reduced in the exposed workers and was related to smoking and to lung function variables, reflecting obstructive airways disease. There was no significant correlation between exercise capacity and exposure to asbestos cement.
Full text
PDF![542](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9813/1007873/be0807028c1a/brjindmed00160-0038.png)
![543](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9813/1007873/251d561aa808/brjindmed00160-0039.png)
![544](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9813/1007873/3f881c58f21e/brjindmed00160-0040.png)
![545](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9813/1007873/805311708150/brjindmed00160-0041.png)
![546](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9813/1007873/7a12fffc632a/brjindmed00160-0042.png)
![547](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9813/1007873/c2143e6f1b78/brjindmed00160-0043.png)
![548](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9813/1007873/5c6713798b31/brjindmed00160-0044.png)
![549](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9813/1007873/c491fbc16251/brjindmed00160-0045.png)
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ahlström H., Jonson B. Pulmonary mechanics in infants. Methodological aspects. Scand J Respir Dis. 1974;55(2):129–140. [PubMed] [Google Scholar]
- BERGLUND E., BIRATH G., BJURE J., GRIMBY G., KJELLMER I., SANDQVIST L., SODERHOLM B. Spirometric studies in normal subjects. I. Forced expirograms in subjects between 7 and 70 years of age. Acta Med Scand. 1963 Feb;173:185–192. [PubMed] [Google Scholar]
- Bader M. E., Bader R. A., Teirstein A. S., Miller A., Selikoff I. J. Pulmonary function and radiographic changes in 598 workers with varying duration of exposure to asbestos. Mt Sinai J Med. 1970 Jul-Aug;37(4):492–500. [PubMed] [Google Scholar]
- Becklake M. R. Asbestos-related diseases of the lung and other organs: their epidemiology and implications for clinical practice. Am Rev Respir Dis. 1976 Jul;114(1):187–227. doi: 10.1164/arrd.1976.114.1.187. [DOI] [PubMed] [Google Scholar]
- Becklake M. R., Fournier-Massey G., Rossiter C. E., McDonald J. C. Lung function in chrysotile asbestos mine and mill workers of Quebec. Arch Environ Health. 1972 Jun;24(6):401–409. doi: 10.1080/00039896.1972.10666115. [DOI] [PubMed] [Google Scholar]
- Berry G., Gilson J. C., Holmes S., Lewinsohn H. C., Roach S. A. Asbestosis: a study of dose-response relationships in an asbestos textile factory. Br J Ind Med. 1979 May;36(2):98–112. doi: 10.1136/oem.36.2.98. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Epler G. R., Saber F. A., Gaensler E. A. Determination of severe impairment (disability) in interstitial lung disease. Am Rev Respir Dis. 1980 Apr;121(4):647–659. doi: 10.1164/arrd.1980.121.4.647. [DOI] [PubMed] [Google Scholar]
- Harless K. W., Watanabe S., Renzetti A. D., Jr The acute effects of chrysotile asbestos exposure on lung function. Environ Res. 1978 Jul;16(1-3):360–372. doi: 10.1016/0013-9351(78)90169-x. [DOI] [PubMed] [Google Scholar]
- Hourihane D. O., McCaughey W. T. Pathological aspects of asbestosis. Postgrad Med J. 1966 Oct;42(492):613–622. doi: 10.1136/pgmj.42.492.613. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Howard J., Mohsenifar Z., Brown H. V., Koerner S. K. Role of exercise testing in assessing functional respiratory impairment due to asbestos exposure. J Occup Med. 1982 Sep;24(9):685–689. doi: 10.1097/00043764-198209000-00016. [DOI] [PubMed] [Google Scholar]
- Jodoin G., Gibbs G. W., Macklem P. T., McDonald J. C., Becklake M. R. Early effects of asbestos exposure on lung function. Am Rev Respir Dis. 1971 Oct;104(4):525–535. doi: 10.1164/arrd.1971.104.4.525. [DOI] [PubMed] [Google Scholar]
- Johansson L. G., Albin M. P., Jakobsson K. M., Welinder H. E., Ranstam P. J., Attewell R. G. Ferruginous bodies and pulmonary fibrosis in dead low to moderately exposed asbestos cement workers: histological examination. Br J Ind Med. 1987 Aug;44(8):550–558. doi: 10.1136/oem.44.8.550. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Leathart G. L. Pulmonary function tests in asbestos workers. Trans Soc Occup Med. 1968 Apr;18(2):49–55. doi: 10.1093/occmed/18.1.49. [DOI] [PubMed] [Google Scholar]
- Lebowitz M. D. Occupational exposures in relation to symptomatology and lung function in a community population. Environ Res. 1977 Aug;14(1):59–67. doi: 10.1016/0013-9351(77)90066-4. [DOI] [PubMed] [Google Scholar]
- McDonald J. C., Becklake M. R., Fournier-Massey G., Rossiter C. E. Respiratory symptoms in chrysotile asbestos mine and mill workers of Quebec. Arch Environ Health. 1972 May;24(5):358–363. doi: 10.1080/00039896.1972.10666104. [DOI] [PubMed] [Google Scholar]
- McDonald J. C., Becklake M. R., Gibbs G. W., McDonald A. D., Rossiter C. E. The health of chrysotile asbestos mine and mill workers of Quebec. Arch Environ Health. 1974 Feb;28(2):61–68. doi: 10.1080/00039896.1974.10666438. [DOI] [PubMed] [Google Scholar]
- Morgan W. K. Industrial bronchitis. Br J Ind Med. 1978 Nov;35(4):285–291. doi: 10.1136/oem.35.4.285. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Murphy R. L., Jr, Gaensler E. A., Redding R. A., Belleau R., Keelan P. J., Smith A. A., Goff A. M., Ferris B. G., Jr Low exposure to asbestos. Gas exchange in ship pipe coverers and controls. Arch Environ Health. 1972 Oct;25(4):253–264. doi: 10.1080/00039896.1972.10666171. [DOI] [PubMed] [Google Scholar]
- OTIS A. B., MCKERROW C. B., BARTLETT R. A., MEAD J., MCILROY M. B., SELVER-STONE N. J., RADFORD E. P., Jr Mechanical factors in distribution of pulmonary ventilation. J Appl Physiol. 1956 Jan;8(4):427–443. doi: 10.1152/jappl.1956.8.4.427. [DOI] [PubMed] [Google Scholar]
- Ohlson C. G., Rydman T., Sundell L., Bodin L., Hogstedt C. Decreased lung function in long-term asbestos cement workers: a cross-sectional study. Am J Ind Med. 1984;5(5):359–366. doi: 10.1002/ajim.4700050504. [DOI] [PubMed] [Google Scholar]
- Parkes W. R. Asbestos-related disorders. Br J Dis Chest. 1973 Oct;67(4):261–300. doi: 10.1016/s0007-0971(73)80001-4. [DOI] [PubMed] [Google Scholar]
- Pearle J. Exercise performance and functional impairment in asbestos-exposed workers. Chest. 1981 Dec;80(6):701–705. doi: 10.1378/chest.80.6.701. [DOI] [PubMed] [Google Scholar]
- Rodriguez-Roisin R., Merchant J. E., Cochrane G. M., Hickey B. P., Turner-Warwick M., Clark T. J. Maximal expiratory flow volume curves in workers exposed to asbestos. Respiration. 1980;39(3):158–165. doi: 10.1159/000194211. [DOI] [PubMed] [Google Scholar]
- Siesjö B. K., Kjällquist A. A new theory for the regulation of the extracellular pH in the brain. Scand J Clin Lab Invest. 1969 Aug;24(1):1–9. doi: 10.3109/00365516909080124. [DOI] [PubMed] [Google Scholar]
- Sue D. Y., Oren A., Hansen J. E., Wasserman K. Lung function and exercise performance in smoking and nonsmoking asbestos-exposed workers. Am Rev Respir Dis. 1985 Sep;132(3):612–618. doi: 10.1164/arrd.1985.132.3.612. [DOI] [PubMed] [Google Scholar]
- Weill H., Waggenspack C., Bailey W., Ziskind M., Rossiter C. Radiographic and physiologic patterns among workers engaged in manufacture of asbestos cement products: a preliminary report. J Occup Med. 1973 Mar;15(3):248–252. [PubMed] [Google Scholar]
- Weill H., Ziskind M. M., Waggenspack C., Rossiter C. E. Lung function consequences of dust exposure in asbestos cement manufacturing plants. Arch Environ Health. 1975 Feb;30(2):88–97. doi: 10.1080/00039896.1975.10666650. [DOI] [PubMed] [Google Scholar]