Abstract
Two groups of 48 rats of the AF/HAN strain were exposed for one year to respirable dust clouds of UICC chrysotile asbestos at a dose level of 10 mg/m3. One group was treated with dust carrying the normal electrostatic charge produced during dust generation, whereas the other was exposed to dust discharged by exposure to ionising radiation from a thallium-204 source. After dusting most animals were retained for their full life span. At the end of the dusting period those animals treated with normally charged dust had significantly more chrysotile retained in their lungs than animals exposed to discharged dust. Subsequently, animals treated with normally charged dust developed more pulmonary fibrosis and more pulmonary tumours. These findings suggest that the charge carried by airborne fibres should be taken into account when considering the health risks from exposure to chrysotile. Highly charged fibres are more likely to be deposited in lung tissue and thus constitute a greater hazard.
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- Bolton R. E., Vincent J. H., Jones A. D., Addison J., Beckett S. T. An overload hypothesis for pulmonary clearance of UICC amosite fibres inhaled by rats. Br J Ind Med. 1983 Aug;40(3):264–272. doi: 10.1136/oem.40.3.264. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Davis J. M., Addison J., Bolton R. E., Donaldson K., Jones A. D. Inhalation and injection studies in rats using dust samples from chrysotile asbestos prepared by a wet dispersion process. Br J Exp Pathol. 1986 Feb;67(1):113–129. [PMC free article] [PubMed] [Google Scholar]
- Davis J. M., Addison J., Bolton R. E., Donaldson K., Jones A. D., Miller B. G. Inhalation studies on the effects of tremolite and brucite dust in rats. Carcinogenesis. 1985 May;6(5):667–674. doi: 10.1093/carcin/6.5.667. [DOI] [PubMed] [Google Scholar]
- Davis J. M., Addison J., Bolton R. E., Donaldson K., Jones A. D., Smith T. The pathogenicity of long versus short fibre samples of amosite asbestos administered to rats by inhalation and intraperitoneal injection. Br J Exp Pathol. 1986 Jun;67(3):415–430. [PMC free article] [PubMed] [Google Scholar]
- Davis J. M., Beckett S. T., Bolton R. E., Collings P., Middleton A. P. Mass and number of fibres in the pathogenesis of asbestos-related lung disease in rats. Br J Cancer. 1978 May;37(5):673–688. doi: 10.1038/bjc.1978.105. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ferin J., Mercer T. T., Leach L. J. The effect of aerosol charge on the deposition and clearance of TiO2 particles in rats. Environ Res. 1983 Jun;31(1):148–151. doi: 10.1016/0013-9351(83)90071-3. [DOI] [PubMed] [Google Scholar]
- John W., Vincent J. H. Static electrification of workplace aerosols: a perspective. Ann Occup Hyg. 1985;29(2):285–288. doi: 10.1093/annhyg/29.2.285. [DOI] [PubMed] [Google Scholar]
- Le Fur G. A propos du mécanisme d'action supposé des antidépresseurs. Encephale. 1980;6(4):303–313. [PubMed] [Google Scholar]
- Middleton A. P., Beckett S. T., Davis J. M. Further observations on the short-term retention and clearance of asbestos by rats, using UICC reference samples. Ann Occup Hyg. 1979;22(2):141–152. doi: 10.1093/annhyg/22.2.141. [DOI] [PubMed] [Google Scholar]
- Stein R. L. Deposition of aerosols on a charged polystyrene surface. Am Ind Hyg Assoc J. 1972 Dec;33(12):775–783. doi: 10.1080/0002889728506745. [DOI] [PubMed] [Google Scholar]
- Vincent J. H., Johnston W. B., Jones A. D., Johnston A. M. Static electrification of airborne asbestos: a study of its causes, assessment and effects on deposition in the lungs of rats. Am Ind Hyg Assoc J. 1981 Oct;42(10):711–721. doi: 10.1080/15298668191420585. [DOI] [PubMed] [Google Scholar]