Abstract
The lungs from 36 past workers at an east London asbestos factory who had died from asbestos related disease were compared with lung tissue from 56 matched control patients being operated on in east London for carcinoma of the lung, correlating the severity of asbestosis and the presence of pulmonary carcinoma or mesothelioma of the pleura or peritoneum with an asbestos exposure index and type and amount of mineral fibre in the lungs. Asbestosis was associated with far heavier fibre burdens than mesothelioma. There was also a striking difference in the degree of asbestosis between the subjects with mesothelioma and those with carcinoma of the lung, the asbestosis being more severe in the latter. A further finding was that crocidolite and amosite were strongly associated with asbestosis, carcinoma of the lung complicating asbestosis, and mesothelioma, whereas no such correlation was evident with chrysotile or mullite. It is suggested that more emphasis should be placed on the biological differences between amphibole and serpentine asbestos fibre.
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Selected References
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- Becklake M. R. Asbestos-related diseases of the lung and other organs: their epidemiology and implications for clinical practice. Am Rev Respir Dis. 1976 Jul;114(1):187–227. doi: 10.1164/arrd.1976.114.1.187. [DOI] [PubMed] [Google Scholar]
- Churg A. Asbestos fibers and pleural plaques in a general autopsy population. Am J Pathol. 1982 Oct;109(1):88–96. [PMC free article] [PubMed] [Google Scholar]
- Churg A. Fiber counting and analysis in the diagnosis of asbestos-related disease. Hum Pathol. 1982 Apr;13(4):381–392. doi: 10.1016/s0046-8177(82)80227-x. [DOI] [PubMed] [Google Scholar]
- Churg A. Malignant mesothelioma in British Columbia in 1982. Cancer. 1985 Feb 1;55(3):672–674. doi: 10.1002/1097-0142(19850201)55:3<672::aid-cncr2820550333>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
- McDonald A. D., McDonald J. C., Pooley F. D. Mineral fibre content of lung in mesothelial tumours in North America. Ann Occup Hyg. 1982;26(1-4):417–422. [PubMed] [Google Scholar]
- Newhouse M. L. A study of the mortality of workers in an asbestos factory. Br J Ind Med. 1969 Oct;26(4):294–301. doi: 10.1136/oem.26.4.294. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Newhouse M. L., Berry G., Wagner J. C. Mortality of factory workers in east London 1933-80. Br J Ind Med. 1985 Jan;42(1):4–11. doi: 10.1136/oem.42.1.4. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pooley F. D. An examination of the fibrous mineral content of asbestos lung tissue from the Canadian chrysotile mining industry. Environ Res. 1976 Dec;12(3):281–298. doi: 10.1016/0013-9351(76)90038-4. [DOI] [PubMed] [Google Scholar]
- Roggli V. L., Pratt P. C., Brody A. R. Asbestos content of lung tissue in asbestos associated diseases: a study of 110 cases. Br J Ind Med. 1986 Jan;43(1):18–28. doi: 10.1136/oem.43.1.18. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Soter N. A., Wasserman S. I., Austen K. F. Cold urticaria: release into the circulation of histamine and eosinophil chemotactic factor of anaphylaxis during cold challenge. N Engl J Med. 1976 Mar 25;294(13):687–690. doi: 10.1056/NEJM197603252941302. [DOI] [PubMed] [Google Scholar]
- Wagner J. C., Moncrieff C. B., Coles R., Griffiths D. M., Munday D. E. Correlation between fibre content of the lungs and disease in naval dockyard workers. Br J Ind Med. 1986 Jun;43(6):391–395. doi: 10.1136/oem.43.6.391. [DOI] [PMC free article] [PubMed] [Google Scholar]