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. 1976 Feb;33(1):25–28. doi: 10.1136/oem.33.1.25

Induction of fibrogenesis by lung antibody-treated macrophages.

D M Lewis, R Burrell
PMCID: PMC1008098  PMID: 1268104

Abstract

Using a modification of an in vitro model of fibrogenesis, lung connective tissue antibodies have been shown to stimulate macrophages to release a collagen stimulating factor acting on fibroblast target cells. This stimulation was measured by increased hydroxyproline production from fibroblasts that had reached stationary growth phase. In subcytotoxic amounts, this antibody had no such effect directly on fibroblasts. These findings further illustrate the value of studying fibrogenesis by the in vitro method.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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