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[Preprint]. 2023 Mar 29:2023.03.28.534594. [Version 1] doi: 10.1101/2023.03.28.534594

Figure 12: Model of terpene antinociception in CIPN.

Figure 12:

Under the condition of paclitaxel (TAX) treatment, terpene injection results in activation of the A2AR in the spinal cord, leading to antinociception. Separately, opioid injection can activate the MOR at an undefined site which enhances terpene pain relief.