Table 1: Terpene binding energies in the orthosteric pockets of the A_2AR and the MOR.

Binding energies (Kcal/Mol) as a result of molecular docking simulation are shown for each terpene at each receptor. The binding energies were moderate to low, which may explain the high doses/concentrations required for activation. The energies were also similar for the A_2AR and the MOR, despite demonstrated lack of terpene activation of the MOR. Insight from the analysis of interacting residues in Figure 11 may explain this apparent discrepancy.

Terpene	A2aR S (Kcal/Mol)	MOR S (Kcal/Mol)
Geraniol	−5.1	−5.5
Linalool	−5.16	−5.34
β-Pinene	−4.51	−4.35
α-Humulene	−4.98	−4.94
β-Caryophyllene	−4.67	−5.07