Abstract
Acrylamide produces ataxia and limb weakness in rats when given in repeated oral doses of 25 100 mg./kg. at various intervals or mixed with the diet in concentrations of 100 to 400 p.p.m.
An electrophysiological and histological study of peripheral nerves has been carried out in chronical poisoned rats. In animals with severe clinical abnormalities, motor nerve conduction velocity in the fibr supplying the small muscles of the hind paw was reduced to approximately 80% of the control value.
Histologically, degeneration of axis cylinders and myelin sheaths was found in peripheral nerve affecting predominantly the distal parts of the longest fibres.
When paralysed animals were no longer given acrylamide, they recovered clinically, conduction velocity returned to the normal range, and there was histological evidence of regeneration of nerve fibres.
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- Cavanagh J. B. The significance of the "dying back" process in experimental and human neurological disease. Int Rev Exp Pathol. 1964;3:219–267. [PubMed] [Google Scholar]
- GILLIATT R. W., WILSON T. G. Ischaemic sensory loss in patients with peripheral nerve lesions. J Neurol Neurosurg Psychiatry. 1954 May;17(2):104–114. doi: 10.1136/jnnp.17.2.104. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GUTMANN E., HOLUBAR J. The degeneration of peripheral nerve fibers. J Neurol Neurosurg Psychiatry. 1950 May;13(2):89–105. doi: 10.1136/jnnp.13.2.89. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KAESER H. E. [Function tests of peripheral nerves in experimental polyneuritis and in wallerian degeneration]. Dtsch Z Nervenheilkd. 1962;183:268–304. [PubMed] [Google Scholar]
- LUBINSKA L. Intercalated internodes in nerve fibres. Nature. 1958 Apr 5;181(4614):957–958. doi: 10.1038/181957a0. [DOI] [PubMed] [Google Scholar]
- MARGOLIS G., PICKETT J. P. New applications of the Luxol fast blue myelin stain. Lab Invest. 1956 Nov-Dec;5(6):459–474. [PubMed] [Google Scholar]
- Morgan-Hughes J. A. Changes in motor nerve conduction velocity in diphtheritic polyneuritis. Riv Patol Nerv Ment. 1965 Apr;86(2):253–260. [PubMed] [Google Scholar]
- THOMAS P. K., FULLERTON P. M. NERVE FIBRE SIZE IN THE CARPAL TUNNEL SYNDROME. J Neurol Neurosurg Psychiatry. 1963 Dec;26:520–527. doi: 10.1136/jnnp.26.6.520. [DOI] [PMC free article] [PubMed] [Google Scholar]
- THOMAS P. K. Growth changes in the myelin sheath of peripheral nerve fibres in fishes. Proc R Soc Lond B Biol Sci. 1955 Mar 15;143(912):380–391. doi: 10.1098/rspb.1955.0018. [DOI] [PubMed] [Google Scholar]
- Vizoso A. D., Young J. Z. Internode length and fibre diameter in developing and regenerating nerves. J Anat. 1948 Apr;82(Pt 1-2):110–134.1. [PMC free article] [PubMed] [Google Scholar]
- WAKSMAN B. H., ADAMS R. D. A comparative study of experimental allergic neuritis in the rabbit, guinea pig, and mouse. J Neuropathol Exp Neurol. 1956 Jul;15(3):293–334. doi: 10.1097/00005072-195607000-00005. [DOI] [PubMed] [Google Scholar]