Abstract
The toxicity of triphenyltin has been determined after its acute oral and intraperitoneal administration in rats, guinea-pigs, rabbits, mice, and hens, after feeding it to rats and guinea-pigs, and after its application to the skin of guinea-pigs.
The guinea-pig was the most sensitive species and its growth was inhibited by as little as 1 p.p.m. triphenyltin acetate in the diet. With higher concentrations in the diet the relationships between the dose and the survival time and between the amount consumed and the acute oral LD50 indicated that triphenyltin accumulated in the guinea-pig.
Compared with those of triethyltin, the effects of triphenyltin appeared relatively non-specific, but there was evidence of an action on the central nervous system although cerebral oedema did not occur. The effects of triphenyltin were quite different from those of diphenyltin which acted mainly as an irritant.
Triphenyltin did not readily penetrate unbroken skin.
The use of triphenyltin as an agricultural fungicide is considered in the discussion.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aldridge W. N., Street B. W. Oxidative phosphorylation. Biochemical effects and properties of trialkyltins. Biochem J. 1964 May;91(2):287–297. doi: 10.1042/bj0910287. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CREMER J. E. The metabolism in vitro of tissue slices from rats given triethyltin compounds. Biochem J. 1957 Sep;67(1):87–96. doi: 10.1042/bj0670087. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FRANCIS J. I., BARNES J. M. STUDIES ON THE MAMMALIAN TOXICITY OF FENTHION. Bull World Health Organ. 1963;29:205–212. [PMC free article] [PubMed] [Google Scholar]
- HEROK J., GOETTE H. RADIOMETRISCHE UNTERSUCHUNGEN UEBER DAS VERHALTEN VON TRIPHENYLZINNACETAT IN PFLANZE UND TIER. Int J Appl Radiat Isot. 1963 Oct;14:461–479. doi: 10.1016/0020-708x(63)90032-2. [DOI] [PubMed] [Google Scholar]
- KALSBECK J. E., CUMINGS J. N. Experimental edema in the rat and cat brain. J Neuropathol Exp Neurol. 1963 Apr;22:237–247. doi: 10.1097/00005072-196304000-00002. [DOI] [PubMed] [Google Scholar]
- KLIMMER O. R. [Triphenyltin acetate--a contribution to the toxicology of organic tin compounds]. Arzneimittelforschung. 1963 Jun;13:432–436. [PubMed] [Google Scholar]
- Scholz J. Chronic toxicity testing. Nature. 1965 Aug 21;207(999):870–871. doi: 10.1038/207870a0. [DOI] [PubMed] [Google Scholar]
- TAUBERGER G. TIEREXPERIMENTELLE ANALYSE DER TRIPHENYLZINNWIRKUNG NACH INTRAVENOESER INJEKTION. Med Exp Int J Exp Med. 1963;9:393–399. [PubMed] [Google Scholar]