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. 1966 Oct;23(4):249–262.

Trichloroethylene: A Review

G F Smith 1
PMCID: PMC1008464  PMID: 5332897

Abstract

The physical and chemical characteristics of trichlorethylene are discussed together with its uses in industry and medical practice. Chemical and physical methods of the estimation of trichlorethylene in air have been described, including the use of gas detector tubes, which today is the method most commonly employed.

The metabolism of trichlorethylene was systematically investigated by Butler (1948), who in animals established the identity of the main metabolites appearing in the urine, Powell (1945a, b) having also done this in human subjects. The excretion of these metabolites has since been repeatedly investigated, but the intermediate breakdown products within the body as well as the organ mainly responsible still remain uncertain.

The acute toxicity of trichlorethylene, manifested preponderantly by central nervous system effects, came to be recognized during the second decade of this century, not long after its introduction as a substitute for benzol as a degreasant in Germany during the First World War. The recognition of a possible chronic toxic effect, characterized by a mild psycho-organic syndrome, came much later and is still not universally accepted. Damage to the trigeminal nerve after closed-circuit trichlorethylene anaesthesia was observed soon after its introduction as a general anaesthetic 30 to 40 years ago, and it was shown to be due to breakdown to dichloracetylene in carbon dioxide absorbers. The pure substance seems otherwise not to have a specific effect on this nerve. The balance of opinion, based on human observations and on animal experiments, is against a severe toxic effect on the liver, although individual cases of liver damage in industrial workers have been reported. The sudden fatal collapse of young workers during mild exercise has on rare occasions been described, there being in most cases an element of heavy exposure. Investigations on man and animals indicate that pure trichlorethylene has no severe effect on other systems of the body.

Maximum permissible levels for trichlorethylene in air were reduced from 400 p.p.m. in 1947 to 200 p.p.m., and in 1961 there was a further reduction to 100 p.p.m., which, except in the Soviet Union, is at present accepted in most parts of the world.

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Selected References

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  1. ADAMS E. M., SPENCER H. C., ROWE V. K., McCOLLISTER D. D., IRISH D. D. Vapor toxicity of trichloroethylene determined by experiments on laboratory animals. AMA Arch Ind Hyg Occup Med. 1951 Nov;4(5):469–481. [PubMed] [Google Scholar]
  2. BARNES J. M. Mode of action of some toxic substance, with social reference to the effects of prolonged exposure. Br Med J. 1961 Oct 28;2(5260):1097–1104. doi: 10.1136/bmj.2.5260.1097. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BARTONICEK V., SOUCEK B. [Metabolism of trichloroethylene in dogs]. Arch Gewerbepathol Gewerbehyg. 1959;17:283–293. [PubMed] [Google Scholar]
  4. BATTIG K., GRANDJEAN E. CHRONIC EFFECTS OF TRICHLOROETHYLENE ON RAT BEHAVIOR. EFFECTS ON SWIMMING PERFORMANCE, EXPLORATORY BEHAVIOR, AND MAZE AND AVOIDANCE LEARNING. Arch Environ Health. 1963 Dec;7:694–699. doi: 10.1080/00039896.1963.10663602. [DOI] [PubMed] [Google Scholar]
  5. BEDFORD J., HICKISH D. E., SMITH J. H. Exposure to trichloro-ethylene during an industrial degreasing operation. Br J Ind Med. 1956 Oct;13(4):290–293. doi: 10.1136/oem.13.4.290. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. BERNSTINE M. L. Cardiac arrest occurring under trichloroethylene analgesia; report of a case with recovery. AMA Arch Surg. 1954 Feb;68(2):262–266. doi: 10.1001/archsurg.1954.01260050264014. [DOI] [PubMed] [Google Scholar]
  7. Brain F. H., Helliwell P. J. The estimation of trichloroethylene in blood. Biochem J. 1949;45(1):75–79. doi: 10.1042/bj0450075. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. CALVET J., PLANQUES J., RIBET A., COLL J. Intoxication aiguë par le trichloréthylène; guérison. Arch Mal Prof. 1959 May-Jun;20(3):297–299. [PubMed] [Google Scholar]
  9. CARPENTER C. P., SMYTH H. F., Jr, POZZANI U. C. The assay of acute vapor toxicity, and the grading and interpretation of results on 96 chemical compounds. J Ind Hyg Toxicol. 1949 Nov;31(6):343–346. [PubMed] [Google Scholar]
  10. CHALUPA B., SYNKOVA J., SEVCIK M. The assessment of electroencephalographic changes and memory disturbances in acute intoxications with industrial poisons. Br J Ind Med. 1960 Jul;17:238–241. doi: 10.1136/oem.17.3.238. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. CLAYTON J. I., PARKHOUSE J. Blood trichloroethylene concentrations during anaesthesia under controlled conditions. Br J Anaesth. 1962 Mar;34:141–148. doi: 10.1093/bja/34.3.141. [DOI] [PubMed] [Google Scholar]
  12. CONDON H. A. Convulsions under trilene anaesthesia. Br Med J. 1948 Aug 14;2(4571):340–340. doi: 10.1136/bmj.2.4571.340. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. DAVENPORT H. T. Damage to the skin due to trilene. Br J Anaesth. 1951 Jan;23(1):56–57. doi: 10.1093/bja/23.1.56. [DOI] [PubMed] [Google Scholar]
  14. Dodds G. H. Liver Necrosis and Bilateral Suprarenal Haemorrhage in the Puerperium. Br Med J. 1945 Jun 2;1(4404):769–770. doi: 10.1136/bmj.1.4404.769. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. ELKINS H. B. Analyses of biological materials as indices of exposure to organic solvents. AMA Arch Ind Hyg Occup Med. 1954 Mar;9(3):212–222. [PubMed] [Google Scholar]
  16. FRIBERG L., KYLIN B., NYSTROM A. Toxicities of trichlorethylene and tetrachloroethylene and Fujiwara's pyridine-alkali reaction. Acta Pharmacol Toxicol (Copenh) 1953;9(4):303–312. [PubMed] [Google Scholar]
  17. GIEVER P. M., COOK W. A. Automatic recording instruments as applied to air analysis. AMA Arch Ind Health. 1960 Mar;21:233–249. [PubMed] [Google Scholar]
  18. GUTCH C. F., TOMHAVE W. G., STEVENS S. C. ACUTE RENAL FAILURE DUE TO INHALATION OF TRICHLORETHYLENE. Ann Intern Med. 1965 Jul;63:128–134. doi: 10.7326/0003-4819-63-1-128. [DOI] [PubMed] [Google Scholar]
  19. HELLIWELL P. J., HUTTON A. M. Trichlorethylene anaesthesia. Anaesthesia. 1950 Jan;5(1):4–13. doi: 10.1111/j.1365-2044.1950.tb13680.x. [DOI] [PubMed] [Google Scholar]
  20. Hewer C. L. Trichlorethylene as a General Analgesic and Anaesthetic. Proc R Soc Med. 1942 May;35(7):463–468. [PMC free article] [PubMed] [Google Scholar]
  21. JORON G. E., CAMERON D. G., HALPENNY G. W. Massive necrosis of the liver due to trichlorethylene. Can Med Assoc J. 1955 Dec 1;73(11):890–891. [PMC free article] [PubMed] [Google Scholar]
  22. KYLIN B., REICHARD H., SUMEGI I., YLLNER S. Hepatotoxic effect of tri- and tetrachlorethylene on mice. Nature. 1962 Jan 27;193:395–395. doi: 10.1038/193395a0. [DOI] [PubMed] [Google Scholar]
  23. LOGAN C. J., STENTIFORD H. B. Trichloroethylene poisoning. Lancet. 1956 Sep 29;271(6944):659–660. doi: 10.1016/s0140-6736(56)92343-1. [DOI] [PubMed] [Google Scholar]
  24. LONGLEY E. O., JONES R. ACUTE TRICHLOROETHYLENE NARCOSIS. ACCIDENT INVOLVING THE USE OF TRICHLOROETHYLENE IN A CONFINED SPACE. Arch Environ Health. 1963 Aug;7:249–252. doi: 10.1080/00039896.1963.10663520. [DOI] [PubMed] [Google Scholar]
  25. LUEZ G. [Method of job classification]. Arch Mal Prof. 1962 Oct-Nov;23:693–697. [PubMed] [Google Scholar]
  26. MORGAN D. J. ASSESSMENT OF EXPOSURE TO TRICHLORETHYLENE. Ann Occup Hyg. 1964 Dec;7:365–367. doi: 10.1093/annhyg/7.4.365. [DOI] [PubMed] [Google Scholar]
  27. McBIRNEY R. S. Trichloroethylene and dichloroethylene poisoning. AMA Arch Ind Hyg Occup Med. 1954 Aug;10(2):130–133. [PubMed] [Google Scholar]
  28. O'CONNOR W. A. A case of trichlorethylene addiction. Br Med J. 1954 Aug 21;2(4885):451–452. doi: 10.1136/bmj.2.4885.451. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Pask E. A. Convulsions. Proc R Soc Med. 1942 Jun;35(8):545–548. [PMC free article] [PubMed] [Google Scholar]
  30. RIVOIRE J., GENEVOIS M., TOLOT F. [Elimination of trichloroacetic acid in subjects exposed to trichloroethylene. Results of the routine use of this method in an industrial plant]. Arch Mal Prof. 1962 Jun;23:395–399. [PubMed] [Google Scholar]
  31. TALVITIE N. A. New techniques for evaluating environmental exposures. AMA Arch Ind Health. 1958 May;17(5):563–570. [PubMed] [Google Scholar]
  32. TUBICH G. E., DAVIS I. H., BLOOMFIELD B. D. Occupational health studies of the shell-molding process. AMA Arch Ind Health. 1960 May;21:424–444. [PubMed] [Google Scholar]

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