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. 1980 Aug;37(3):213–221. doi: 10.1136/oem.37.3.213

Angiosarcoma of the liver: annual occurrence and aetiology in Great Britain.

P J Baxter, P P Anthony, R N Macsween, P J Scheuer
PMCID: PMC1008697  PMID: 7191719

Abstract

The annual occurrence of angiosarcoma of the liver (ASL) in Britain from 1963 to 1977 was studied, including clinical and occupational details for those cases agreed as ASL by a panel of histopathologists. Thirty-five cases (28 men, six women, and one infant girl) were agreed as ASL. The increase in the incidence of ASL observed in recent years was attributable to Thorotrast (thorium dioxide) usage (eight cases) and exposure to vinyl chloride (two cases) in the past. In its clinical presentation and prognosis ASL resembled primary liver carcinoma, except that extrahepatic metastases were found in only eight (23%) cases, and haemoperitoneum ws more common in those cases due to Thorotrast. The results suggested a possible increased risk of ASL in the electrical and plastics fabrication industries, but information on exposure was inadequate to implicate specific chemicals. The clinical features of one case were indicative of arsenical intoxication, but medications in the other patients did not appear to be of aetiological importance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alrenga D. P. Primary angiosarcoma of the liver. Review article. Int Surg. 1975 Apr;60(4):198–203. [PubMed] [Google Scholar]
  2. Baxter P. J., Anthony P. P., MacSween R. N., Scheuer P. J. Angiosarcoma of the liver in Great Britain, 1963-73. Br Med J. 1977 Oct 8;2(6092):919–921. doi: 10.1136/bmj.2.6092.919. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Burnett R. A., Patrick R. S., Spilg W. G., Buchanan W. M., Macsween R. N. Hepatocellular carcinoma and hepatic cirrhosis in the west of Scotland: a 25-year necropsy review. J Clin Pathol. 1978 Feb;31(2):108–110. doi: 10.1136/jcp.31.2.108. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Da Silva Horta J., Da Motta C., Tavares M. H. Thorium dioxide effects in man. Epidemiological, clinical, and pathological studies (experience in Portugal). Environ Res. 1974 Oct;8(2):131–159. doi: 10.1016/0013-9351(74)90046-2. [DOI] [PubMed] [Google Scholar]
  5. Doll R., Vessey M. P., Beasley R. W., Buckley A. R., Fear E. C., Fisher R. E., Gammon E. J., Gunn W., Hughes G. O., Lee K. Mortality of gasworkers - final report of a prospective study. Br J Ind Med. 1972 Oct;29(4):394–406. doi: 10.1136/oem.29.4.394. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Donald D., Dawson A. A. Microangiopathic haemolytic anaemia associated with malignant haemangio-endothelioma. J Clin Pathol. 1971 Jul;24(5):456–459. doi: 10.1136/jcp.24.5.456. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fox A. J., Collier P. F. Mortality experience of workers exposed to vinyl chloride monomer in the manufacture of polyvinyl chloride in Great Britain. Br J Ind Med. 1977 Feb;34(1):1–10. doi: 10.1136/oem.34.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Heath C. W., Jr, Falk H., Creech J. L., Jr Characteristics of cases of angiosarcoma of the liver among vinyl chloride workers in the United States. Ann N Y Acad Sci. 1975 Jan 31;246:231–236. doi: 10.1111/j.1749-6632.1975.tb51097.x. [DOI] [PubMed] [Google Scholar]
  9. Infante P. F. Mutagenic and carcinogenic risks associated with halogenated olefins. Environ Health Perspect. 1977 Dec;21:251–254. doi: 10.1289/ehp.7721251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Johnson P. J., Krasner N., Portmann B., Eddleston A. L., Williams R. Hepatocellular carcinoma in Great Britain: influence of age, sex, HBsAg status, and aetiology of underlying cirrhosis. Gut. 1978 Nov;19(11):1022–1026. doi: 10.1136/gut.19.11.1022. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lee F. I., Harry D. S. Angiosarcoma of the liver in a vinyl-chloride worker. Lancet. 1974 Jun 29;1(7870):1316–1318. doi: 10.1016/s0140-6736(74)90683-7. [DOI] [PubMed] [Google Scholar]
  12. MacSween R. N. A clinicopathological review of 100 cases of primary malignant tumours of the liver. J Clin Pathol. 1974 Aug;27(8):669–682. doi: 10.1136/jcp.27.8.669. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. MacSween R. N., Vetters J. M., Ross S. K., Ferguson J., Johnstone J. M., Sandison A. T. Haemangio-endothelial sarcoma of the liver. J Pathol. 1973 Jan;109(1):39–44. doi: 10.1002/path.1711090105. [DOI] [PubMed] [Google Scholar]
  14. Ong G. B., Taw J. L. Spontaneous rupture of hepatocellular carcinoma. Br Med J. 1972 Oct 21;4(5833):146–149. doi: 10.1136/bmj.4.5833.146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Pollard S. M., Millward-Sadler G. H. Malignant haemangioendothelioma involving the liver. J Clin Pathol. 1974 Mar;27(3):214–221. doi: 10.1136/jcp.27.3.214. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Popper H., Thomas L. B., Telles N. C., Falk H., Selikoff I. J. Development of hepatic angiosarcoma in man induced by vinyl chloride, thorotrast, and arsenic. Comparison with cases of unknown etiology. Am J Pathol. 1978 Aug;92(2):349–376. [PMC free article] [PubMed] [Google Scholar]
  18. Syed S., Jung R. T. Cardiac tamponade caused by metastasising haemangioendothelial sarcoma of the liver. Br Heart J. 1978 Jun;40(6):697–699. doi: 10.1136/hrt.40.6.697. [DOI] [PMC free article] [PubMed] [Google Scholar]

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