Effects of carbon disulphide on the liver of rats

E J Bond; W H Butler; F De Matteis; J M Barnes

doi:10.1136/oem.26.4.335

. 1969 Oct;26(4):335–337. doi: 10.1136/oem.26.4.335

Effects of carbon disulphide on the liver of rats

E J Bond ^a,¹, W H Butler ^a, F De Matteis ^a, J M Barnes ^a

PMCID: PMC1008993 PMID: 5346831

Abstract

Bond, E. J., Butler, W. H., de Matteis, F., and Barnes, J. M. (1968).Brit. J. industr. Med.,26, 335-337. Effects of carbon disulphide on the liver of rats. Normal rats surviving a single oral dose of carbon disulphide (CS₂) show liver enlargement and depression of drug-metabolizing enzymes but no liver necrosis. If the drug-metabolizing enzymes are stimulated by phenobarbitone before exposure to CS_2, the LD₅₀ does not change but liver necrosis is produced.