Figure 4.

(A) Schematic illustration of the R-S-NTP serving as a multifunctional sonotheranostics. This sonotheranostics was fabricated via coordinating Fe (III) and TPPS, followed by anchoring with Bis (DPA-Zn)-RGD and manganese superoxide dismutase (SOD₂)-siRNA. The R-S-NTP could substantially accumulate in the tumor via EPR effect and the active tumor-targeting ability of RGD. Upon uptake by cancer cells, the R-S-NTP could specifically down-regulate SOD₂ expression, trigger GSH depletion and Fenton reaction generation, and thus achieve highly efficient anticancer therapy. Reproduced with permission ¹¹³. Copyright 2019, Wiley-VCH. (B) Cu/CaCO₃@Ce6 nanoparticles (CCC NPs)-dominated advanced cancer therapy via multiple reactive oxidative species (ROS) amplification ¹¹⁴. Copyright 2022, Wiley-VCH. (C) Schematic illustration of 2D MXene-originated in situ nanosonosensitizer generation for augmented and synergistic sonodynamic tumor nanotherapy. a) Schematic illustration of the synthesis of Ti₃C₂/CuO₂@BSA nanosheets. (b) Synergetic chemodynamic and sonodynamic therapeutic process of 2D Ti₃C₂/CuO₂@BSA nanosheets under US irradiation. Reproduced with permission ¹¹⁸. Copyright 2022, American Chemical Society. (D) Illustration of a) self-assembly of amphiphilic Janus Au-MnO NPs into functional vesicles and b) their sequential US and GSH-induced disassembly into small JNPs with deep tumor penetration for synergistic SDT/CDT. Reproduced with permission ¹²¹. Copyright 2020, Wiley-VCH.