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British Journal of Industrial Medicine logoLink to British Journal of Industrial Medicine
. 1983 Nov;40(4):384–389. doi: 10.1136/oem.40.4.384

Lung cancer associated with chloromethyl methyl ether manufacture: an investigation at two factories in the United Kingdom.

R I McCallum, V Woolley, A Petrie
PMCID: PMC1009211  PMID: 6226309

Abstract

The prevalence of deaths from lung cancer, other cancer, and all other causes was studied in workers and former workers at two factories (A and B) in the United Kingdom at which chloromethyl methyl ether has been manufactured, at one since about 1948 and at the other since 1956. At factory A in South Wales 571 men were traced and at factory B in the north east of England 1196. A statistically significant excess of observed deaths from lung cancer but not other cancer compared with the number expected was found in factory A when the death rates for the population of Glamorgan were applied. The deaths from lung cancer at factory A were related to risk in terms of total exposure time, and average exposure rate and dosage. The degree of exposure was more important than the duration of exposure. There has so far been no demonstrable excess of deaths from lung cancer in employees working at factory A since the process was changed in 1972. In factory B the risk was low over the whole period, and there was no excess of lung or other cancers compared with the rates for the Tyneside conurbation. Despite improvements in the process in both factories continued surveillance of the workers is needed for some years yet.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DeFonso L. R., Kelton S. C., Jr Lung cancer following exposure to chloromethyl methyl ether. An epidemiological study. Arch Environ Health. 1976 May-Jun;31(3):125–130. doi: 10.1080/00039896.1976.10667205. [DOI] [PubMed] [Google Scholar]
  2. Figueroa W. G., Raszkowski R., Weiss W. Lung cancer in chloromethyl methyl ether workers. N Engl J Med. 1973 May 24;288(21):1096–1097. doi: 10.1056/NEJM197305242882104. [DOI] [PubMed] [Google Scholar]
  3. Laskin S., Kuschner M., Drew R. T., Cappiello V. P., Nelson N. Tumors of the respiratory tract induced by inhalation of bis(chloromethyl)ether. Arch Environ Health. 1971 Aug;23(2):135–136. doi: 10.1080/00039896.1971.10665970. [DOI] [PubMed] [Google Scholar]
  4. Leong B. K., Macfarland H. N., Reese W. H., Jr Induction of lung adenomas by chronic inhalation of bis (chloromethyl) ether. Arch Environ Health. 1971 Jun;22(6):663–666. doi: 10.1080/00039896.1971.10665920. [DOI] [PubMed] [Google Scholar]
  5. Pasternack B. S., Shore R. E., Albert R. E. Occupational exposure to chloromethyl ethers. A retrospective cohort mortality study (1948-1972). J Occup Med. 1977 Nov;19(11):741–746. [PubMed] [Google Scholar]
  6. Thiess A. M., Hey W., Zeller H. Zur Toxikologie von Dichlordimethyläther--Verdacht auf kanzerogene Wirkungauch beim Menschen. Zentralbl Arbeitsmed. 1973 Apr;23(4):97–102. [PubMed] [Google Scholar]
  7. Van Duuren B. L., Goldschmidt B. M., Langseth L., Mercado G., Sivak A. Alpha-haloethers: a new type of alkylating carcinogen. Arch Environ Health. 1968 Apr;16(4):472–476. doi: 10.1080/00039896.1968.10665092. [DOI] [PubMed] [Google Scholar]

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