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. 1971 Apr;28(2):189–194. doi: 10.1136/oem.28.2.189

Balance between intake and output of lead in normal individuals

Jennifer A Thompson 1
PMCID: PMC1009265  PMID: 5572688

Abstract

Thompson, J. A. (1970).Brit. J. industr. Med.,27, 189-194. Balance between intake and output of lead in normal individuals. The amount of lead ingested by a group of five `normal' individuals for a number of consecutive days was determined; during the same period, the amount of lead which was excreted in faeces and urine was also determined and hence, by difference, the amount of lead retained in the body was calculated. The results showed a wide variation from day to day in the lead content of the food, with a range from 70 μg to 750 μg; the average amount was 274 μg. The lead ingested was almost totally eliminated in faeces and urine; the amount of lead excreted daily ranged from 140 μg to 625 μg with an average of 264 μg. Only about 10 μg on average per day, less than 4% of the average daily intake, was retained. At this rate of retention the lead accumulated would almost wholly account for the `normal' body burden of lead found by tissue analysis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bacon A. P., Froome K., Gent A. E., Cooke T. K., Sowerby P. Lead poisoning from drinking soft water. Lancet. 1967 Feb 4;1(7484):264–266. doi: 10.1016/s0140-6736(67)91322-0. [DOI] [PubMed] [Google Scholar]
  2. Barry P. S., Mossman D. B. Lead concentrations in human tissues. Br J Ind Med. 1970 Oct;27(4):339–351. doi: 10.1136/oem.27.4.339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Goldsmith J. R., Hexter A. C. Respiratory exposure to lead: epidemiological and experimental dose-response relationships. Science. 1967 Oct 6;158(3797):132–134. doi: 10.1126/science.158.3797.132. [DOI] [PubMed] [Google Scholar]
  4. Goldwater L. J. "Normal" concentrations of metals in urine and blood. WHO Chron. 1967 May;21(5):191–192. [PubMed] [Google Scholar]
  5. KEHOE R. A. The Harben Lectures, 1960: The metabolism of lead in man in health and disease. 3. Present hygienic problems relating to the absorption of lead. J R Inst Public Health. 1961 Aug;24:177–203. [PubMed] [Google Scholar]
  6. Kubota J., Lazar V. A., Losee F. Copper, zinc, cadmium, and lead in human blood from 19 locations in the United States. Arch Environ Health. 1968 Jun;16(6):788–793. doi: 10.1080/00039896.1968.10665153. [DOI] [PubMed] [Google Scholar]
  7. MONCRIEFF A. A., KOUMIDES O. P., CLAYTON B. E., PATRICK A. D., RENWICK A. G., ROBERTS G. E. LEAD POISONING IN CHILDREN. Arch Dis Child. 1964 Feb;39:1–13. doi: 10.1136/adc.39.203.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. OWEN J. A., IGGO B., SCANDRETT F. J., STEWART C. P. The determination of creatinine in plasma or serum, and in urine; a critical examination. Biochem J. 1954 Nov;58(3):426–437. doi: 10.1042/bj0580426. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. PATTERSON C. C. CONTAMINATED AND NATURAL LEAD ENVIRONMENTS OF MAN. Arch Environ Health. 1965 Sep;11:344–360. doi: 10.1080/00039896.1965.10664229. [DOI] [PubMed] [Google Scholar]
  10. Power J. G., Barnes R. M., Nash W. N., Robinson J. D. Lead poisoning in Gurkha soldiers in Hong Kong. Br Med J. 1969 Aug 9;3(5666):336–337. doi: 10.1136/bmj.3.5666.336. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Schroeder H. A., Tipton I. H. The human body burden of lead. Arch Environ Health. 1968 Dec;17(6):965–978. doi: 10.1080/00039896.1968.10665354. [DOI] [PubMed] [Google Scholar]
  12. Wilson A. T. Acute vertigo and the lead content of food and drink. Practitioner. 1968 Feb;200(196):282–285. [PubMed] [Google Scholar]

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