Abstract
Long term mortality was studied in a group of 57 chromate pigment workers who suffered clinical lead poisoning, mostly between 1930 and 1945. One death was attributed to lead poisoning and there were significant excesses of deaths from nephritis (observed/expected 3/0.24) and cerebrovascular disease (9/2.20), as well as non-significant excesses for respiratory diseases (7/3.59) and accidents and violence (3/1.13). The deaths from nephritis followed long spells of service exceeding 10 years. Poisoning appeared to have more adverse long term effects on older workers: 15 men aged 40 or over at the time of acute poisoning experienced generally high mortality, and 30 years later or by the end of 1981 only two survived instead of the seven expected. The risk of cerebrovascular disease appeared to be unrelated to duration of exposure and affected even men employed for under one year. Excluding the 57 lead poisoned men, other contemporary workers at the factories showed no excess mortality from cerebrovascular disease.
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- Baker E. L., Jr, Landrigan P. J., Barbour A. G., Cox D. H., Folland D. S., Ligo R. N., Throckmorton J. Occupational lead poisoning in the United States: clinical and biochemical findings related to blood lead levels. Br J Ind Med. 1979 Nov;36(4):314–322. doi: 10.1136/oem.36.4.314. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bonnell J. A. Lead smelting at Avonmouth. Br J Ind Med. 1973 Apr;30(2):199–201. doi: 10.1136/oem.30.2.199. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brown C. P., Spivey G. H., Valentine J. L., Browdy B. L. Cigarette smoking and lead levels in occupationally exposed lead workers. J Toxicol Environ Health. 1980 Jul;6(4):877–883. doi: 10.1080/15287398009529906. [DOI] [PubMed] [Google Scholar]
- Cooper W. C., Gaffey W. R. Mortality of lead workers. J Occup Med. 1975 Feb;17(2):100–107. doi: 10.1097/00043764-197502000-00012. [DOI] [PubMed] [Google Scholar]
- DANILOVIC V. Chronic nephritis due to ingestion of lead-contaminated flour. Br Med J. 1958 Jan 4;1(5061):27–28. doi: 10.1136/bmj.1.5061.27. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DINGWALL-FORDYCE I., LANE R. E. A FOLLOW-UP STUDY OF LEAD WORKERS. Br J Ind Med. 1963 Oct;20:313–315. doi: 10.1136/oem.20.4.313. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Davies J. M. Lung cancer mortality among workers making lead chromate and zinc chromate pigments at three English factories. Br J Ind Med. 1984 May;41(2):158–169. doi: 10.1136/oem.41.2.158. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Davies J. M. Lung-cancer mortality of workers making chrome pigments. Lancet. 1978 Feb 18;1(8060):384–384. doi: 10.1016/s0140-6736(78)91103-0. [DOI] [PubMed] [Google Scholar]
- Emmerson B. T. Chronic lead nephropathy. Kidney Int. 1973 Jul;4(1):1–5. doi: 10.1038/ki.1973.73. [DOI] [PubMed] [Google Scholar]
- Fox A. J. The role of OPCS in occupational epidemiology: some examples. Office of Population Censuses and Surveys. Ann Occup Hyg. 1978;21(4):393–403. doi: 10.1093/annhyg/21.4.393. [DOI] [PubMed] [Google Scholar]
- GOLDBLATT M. W. Research in industrial health in the chemical industry. Br J Ind Med. 1955 Jan;12(1):1–20. doi: 10.1136/oem.12.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lilis R., Gavrilescu N., Nestorescu B., Dumitriu C., Roventa A. Nephropathy in chronic lead poisoning. Br J Ind Med. 1968 Jul;25(3):196–202. doi: 10.1136/oem.25.3.196. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Malcolm D., Barnett H. A. A mortality study of lead workers 1925-76. Br J Ind Med. 1982 Nov;39(4):404–410. doi: 10.1136/oem.39.4.404. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Malcolm D. Prevention of long-term sequelae following the absorption of lead. Arch Environ Health. 1971 Oct;23(4):292–298. doi: 10.1080/00039896.1971.10666004. [DOI] [PubMed] [Google Scholar]
- McMichael A. J., Johnson H. M. Long-term mortality profile of heavily-exposed lead smelter workers. J Occup Med. 1982 May;24(5):375–378. doi: 10.1097/00043764-198205000-00008. [DOI] [PubMed] [Google Scholar]
- RADOSEVIC Z., SARIC M., BERITIC T., KNEZEVIC J. The kidney in lead poisoning. Br J Ind Med. 1961 Jul;18:222–230. doi: 10.1136/oem.18.3.222. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shannon H. S., Williams M. K., King E. Sickness absence of lead workers and controls. Br J Ind Med. 1976 Nov;33(4):236–242. doi: 10.1136/oem.33.4.236. [DOI] [PMC free article] [PubMed] [Google Scholar]