Skip to main content
NCBI home page
British Journal of Industrial Medicine logoLink to British Journal of Industrial Medicine
. 1973 Jan;30(1):74–77. doi: 10.1136/oem.30.1.74

Effect of silica on phospholipids in the rat lung

M Grünspan 1, H Antweiler 1, W Dehnen 1
PMCID: PMC1009481  PMID: 4346575

Abstract

Grünspan, M., Antweiler, H., and Dehnen, W. (1973).British Journal of Industrial Medicine,30, 74-77. Effect of silica on phospholipids in the rat lung. The total amount of phospholipids and the contents of sphingomyelin, phosphatidylcholine, phosphatidylserine, and phosphatidylethanolamine have been estimated in the lungs of rats from 2 to 90 days after intra-tracheal injections of quartz and corundum, respectively.

A significant increase in the contents of lung total phospholipids and of all phospholipid fractions examined was caused by quartz. The first increase was noted 48 hours after quartz application; after 30 days the amount of phosphatidylcholine had increased to about 20-fold, whereas the other phospholipid fractions had reached only an amount two or three times as great as in the control animals. The increase observed was steady for up to 90 days at the end of these experiments.

The increase in lung phospholipids was far less when corundum was injected into the lungs.

Full text

PDF
74

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brockmann U., Gercken G. Quantitative eindimensionale Dünnschichtchromatographie der Erythrozytenphospholipide. Clin Chim Acta. 1969 Mar;23(3):489–494. doi: 10.1016/0009-8981(69)90355-6. [DOI] [PubMed] [Google Scholar]
  2. Clark D. G., McElligott T. F., Hurst E. W. The toxicity of paraquat. Br J Ind Med. 1966 Apr;23(2):126–132. doi: 10.1136/oem.23.2.126. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Clements J. A. Comparative lipid chemistry of lungs. Arch Intern Med. 1971 Mar;127(3):387–389. [PubMed] [Google Scholar]
  4. FOLCH J., LEES M., SLOANE STANLEY G. H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957 May;226(1):497–509. [PubMed] [Google Scholar]
  5. Fallon J. T. Specific Tissue Reaction to Phospholipids: A Suggested Explanation for the Similarity of the Lesions of Silicosis and Pulmonary Tubercolosis. Can Med Assoc J. 1937 Mar;36(3):223–228. [PMC free article] [PubMed] [Google Scholar]
  6. Fletcher K., Wyatt I. The composition of lung lipids after poisoning with paraquat. Br J Exp Pathol. 1970 Dec;51(6):604–610. [PMC free article] [PubMed] [Google Scholar]
  7. Grünspan M., Antweiler H. Biochemical and biophysical reactions of rat lung tissue to quartz and corundum with and without PVN-oxide treatment. Inhaled Part. 1970;1:373–378. [PubMed] [Google Scholar]
  8. KARNOVSKY M. L., WALLACH D. F. The metabolic basis of phagocytosis. III. Incorporation of inorganic phosphate into various classes of phosphatides during phagocytosis. J Biol Chem. 1961 Jul;236:1895–1901. [PubMed] [Google Scholar]
  9. Kaw J. L., Gupta G. S., Zaidi S. H. Lung lipids and pulmonary silicosis in rats. Int Arch Arbeitsmed. 1971;27(4):324–330. doi: 10.1007/BF00539363. [DOI] [PubMed] [Google Scholar]
  10. MARKS G. S., MARASAS L. W. Changes in the lung lipids of rabbits and guinea-pigs exposed to the inhalation of silica dust. Br J Ind Med. 1960 Jan;17:31–35. doi: 10.1136/oem.17.1.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. PATTLE R. E. SURFACE LINING OF LUNG ALVEOLI. Physiol Rev. 1965 Jan;45:48–79. doi: 10.1152/physrev.1965.45.1.48. [DOI] [PubMed] [Google Scholar]
  12. von Wichert P. Bezichungen zwischen pathologischen Veränderungen und Phospholipidgehalt der menschlichen Lunge. Pneumonologie. 1971;144(3):201–205. doi: 10.1007/BF02088695. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Industrial Medicine are provided here courtesy of BMJ Publishing Group

RESOURCES