Abstract
Plasma gamma-hexachlorocyclohexane (gamma-HCH) and three urinary trichlorophenols were measured in forestry workers who were engaged in planting seedlings treated with gamma-HCH. These two procedures were assessed as potential biological monitoring methods and the data were compared with reported clinical symptoms. The measurement of plasma gamma-HCH was considered to be a feasible and valid monitoring method for use in routine practice and is a useful indicator of gamma-HCH absorption. The data were used to illustrate the need to be vigilant about personal hygiene and the efficacy of protective clothing. Plasma gamma-HCH concentrations above 70 nmol/l were measured in two workers which coincided with persistent non-specific clinical symptoms. Trichlorophenols were identified in urine but the extensive and variable metabolism of gamma-HCH makes this approach less suitable for biological monitoring.
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Selected References
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- Angerer J., Maass R., Heinrich R. Occupational exposure to hexachlorocyclohexane. VI. Metabolism of gamma-hexachlorocyclohexane in man. Int Arch Occup Environ Health. 1983;52(1):59–67. doi: 10.1007/BF00380608. [DOI] [PubMed] [Google Scholar]
- Baumann K., Angerer J., Heinrich R., Lehnert G. Occupational exposure to hexachlorocyclohexane. I. Body burden of HCH-isomers. Int Arch Occup Environ Health. 1980;47(2):119–127. doi: 10.1007/BF00716371. [DOI] [PubMed] [Google Scholar]
- Baumann K., Behling K., Brassow H. L., Stapel K. Occupational exposure to hexachlorocyclohexane. III neurophysiological findings and neuromuscular function in chronically exposed workers. Int Arch Occup Environ Health. 1981;48(2):165–172. doi: 10.1007/BF00378437. [DOI] [PubMed] [Google Scholar]
- Czeglédi-Jankó G., Avar P. Occupational exposure to lindane: clinical and laboratory findings. Br J Ind Med. 1970 Jul;27(3):283–286. doi: 10.1136/oem.27.3.283. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ginsburg C. M., Lowry W. Absorption of gamma benzene hexachloride following application of Kwell shampoo. Pediatr Dermatol. 1983 Jul;1(1):74–76. doi: 10.1111/j.1525-1470.1983.tb01095.x. [DOI] [PubMed] [Google Scholar]
- Kashyap S. K. Health surveillance and biological monitoring of pesticide formulators in India. Toxicol Lett. 1986 Oct;33(1-3):107–114. doi: 10.1016/0378-4274(86)90075-5. [DOI] [PubMed] [Google Scholar]
- Nigam S. K., Karnik A. B., Majumder S. K., Visweswariah K., Raju G. S., Bai K. M., Lakkad B. C., Thakore K. N., Chatterjee B. B. Serum hexachlorocyclohexane residues in workers engaged at a HCH manufacturing plant. Int Arch Occup Environ Health. 1986;57(4):315–320. doi: 10.1007/BF00406186. [DOI] [PubMed] [Google Scholar]
- Zesch A., Nitzsche K., Lange M. Demonstration of the percutaneous resorption of a lipophilic pesticide and its possible storage in the human body. Arch Dermatol Res. 1982;273(1-2):43–49. doi: 10.1007/BF00509026. [DOI] [PubMed] [Google Scholar]