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. 1989 Sep;46(9):636–642. doi: 10.1136/oem.46.9.636

Respiratory symptoms, lung function, and sensitisation to flour in a British bakery.

A W Musk 1, K M Venables 1, B Crook 1, A J Nunn 1, R Hawkins 1, G D Crook 1, B J Graneek 1, R D Tee 1, N Farrer 1, D A Johnson 1, et al.
PMCID: PMC1009839  PMID: 2789967

Abstract

A survey of dust exposure, respiratory symptoms, lung function, and response to skin prick tests was conducted in a modern British bakery. Of the 318 bakery employees, 279 (88%) took part. Jobs were ranked from 0 to 10 by perceived dustiness and this ranking correlated well with total dust concentration measured in 79 personal dust samples. Nine samples had concentrations greater than 10 mg/m3, the exposure limit for nuisance dust. All participants completed a self administered questionnaire on symptoms and their relation to work. FEV1 and FVC were measured by a dry wedge spirometer and bronchial reactivity to methacholine was estimated. Skin prick tests were performed with three common allergens and with 11 allergens likely to be found in bakery dust, including mites and moulds. Of the participants in the main exposure group, 35% reported chest symptoms which in 13% were work related. The corresponding figures for nasal symptoms were 38% and 19%. Symptoms, lung function, bronchial reactivity, and response to skin prick tests were related to current or past exposure to dust using logistic or linear regression analysis as appropriate. Exposure rank was significantly associated with most of the response variables studied. The study shows that respiratory symptoms and sensitisation are common, even in a modern bakery.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baur X., Fruhmann G., Haug B., Rasche B., Reiher W., Weiss W. Role of Aspergillus amylase in baker's asthma. Lancet. 1986 Jan 4;1(8471):43–43. doi: 10.1016/s0140-6736(86)91924-0. [DOI] [PubMed] [Google Scholar]
  2. Crockcroft D. W., Murdock K. Y., Berscheid B. A. Relationship between atopy and bronchial responsiveness to histamine in a random population. Ann Allergy. 1984 Jul;53(1):26–29. [PubMed] [Google Scholar]
  3. FRANKLAND A. W., LUNN J. A. ASTHMA CAUSED BY THE GRAIN WEEVIL. Br J Ind Med. 1965 Apr;22:157–159. doi: 10.1136/oem.22.2.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Georges P., Delvigne A., de Montis G. RAST et acariens des denrées entreposées. Allerg Immunol (Paris) 1987 Dec;19(10):393-4, 396-7. [PubMed] [Google Scholar]
  5. Herxheimer H. The skin sensitivity to flour of baker's apprentices. A final report of a long term investigation. Acta Allergol. 1973 May;28(1):42–49. [PubMed] [Google Scholar]
  6. James A. L., Cookson W. O., Buters G., Lewis S., Ryan G., Hockey R., Musk A. W. Symptoms and longitudinal changes in lung function in young seasonal grain handlers. Br J Ind Med. 1986 Sep;43(9):587–591. doi: 10.1136/oem.43.9.587. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Järvinen K. A., Pirilä V., Björksten F., Keskinen H., Lehtinen M., Stubb S. Unsuitability of bakery work for a person with atopy: a study of 234 bakery workers. Ann Allergy. 1979 Mar;42(3):192–195. [PubMed] [Google Scholar]
  8. Klaustermeyer W. B., Bardana E. J., Jr, Hale F. C. Pulmonary hypersensitivity to Alternaria and Aspergillus in baker's asthma. Clin Allergy. 1977 May;7(3):227–233. doi: 10.1111/j.1365-2222.1977.tb01447.x. [DOI] [PubMed] [Google Scholar]
  9. Korsgaard J., Dahl R., Iversen M., Hallas T. Storage mites as a cause of bronchial asthma in Denmark. Allergol Immunopathol (Madr) 1985 Mar-Apr;13(2):143–149. [PubMed] [Google Scholar]
  10. Napolitano J., Weiss N. S. Occupational asthma of bakers. Ann Allergy. 1978 Apr;40(4):258–261. [PubMed] [Google Scholar]
  11. Olenchock S. A., Mull J. C., Major P. C. Extracts of airborne grain dusts activate alternative and classical complement pathways. Ann Allergy. 1980 Jan;44(1):23–28. [PubMed] [Google Scholar]
  12. Popescu I. G., Ulmeanu V., Murariu D. Atopic and non-atopic sensitivity in a large bakery. Allergol Immunopathol (Madr) 1981 Jul-Aug;9(4):307–312. [PubMed] [Google Scholar]
  13. Prichard M. G., Ryan G., Musk A. W. Wheat flour sensitisation and airways disease in urban bakers. Br J Ind Med. 1984 Nov;41(4):450–454. doi: 10.1136/oem.41.4.450. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Prichard M. G., Ryan G., Walsh B. J., Musk A. W. Skin test and RAST responses to wheat and common allergens and respiratory disease in bakers. Clin Allergy. 1985 Mar;15(2):203–210. doi: 10.1111/j.1365-2222.1985.tb02274.x. [DOI] [PubMed] [Google Scholar]
  15. Soter N. A., Wasserman S. I., Austen K. F. Cold urticaria: release into the circulation of histamine and eosinophil chemotactic factor of anaphylaxis during cold challenge. N Engl J Med. 1976 Mar 25;294(13):687–690. doi: 10.1056/NEJM197603252941302. [DOI] [PubMed] [Google Scholar]
  16. Thiel H., Ulmer W. T. Bakers' asthma: development and possibility for treatment. Chest. 1980 Aug;78(2 Suppl):400–405. doi: 10.1378/chest.78.2_supplement.400. [DOI] [PubMed] [Google Scholar]
  17. Walsh B. J., Wrigley C. W., Musk A. W., Baldo B. A. A comparison of the binding of IgE in the sera of patients with bakers' asthma to soluble and insoluble wheat-grain proteins. J Allergy Clin Immunol. 1985 Jul;76(1):23–28. doi: 10.1016/0091-6749(85)90799-7. [DOI] [PubMed] [Google Scholar]
  18. Witt C., Stuckey M. S., Woolcock A. J., Dawkins R. L. Positive allergy prick tests associated with bronchial histamine responsiveness in an unselected population. J Allergy Clin Immunol. 1986 May;77(5):698–702. doi: 10.1016/0091-6749(86)90413-6. [DOI] [PubMed] [Google Scholar]
  19. Yan K., Salome C., Woolcock A. J. Rapid method for measurement of bronchial responsiveness. Thorax. 1983 Oct;38(10):760–765. doi: 10.1136/thx.38.10.760. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. van Hage-Hamsten M., Johansson S. G., Johansson E., Wiren A. Lack of allergenic cross-reactivity between storage mites and Dermatophagoides pteronyssinus. Clin Allergy. 1987 Jan;17(1):23–31. doi: 10.1111/j.1365-2222.1987.tb02316.x. [DOI] [PubMed] [Google Scholar]

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