Skip to main content
NCBI home page
British Journal of Industrial Medicine logoLink to British Journal of Industrial Medicine
. 1989 Nov;46(11):791–798. doi: 10.1136/oem.46.11.791

A cytogenetic and haematological investigation of oil exposed workers in a Norwegian cable manufacturing company.

K Skyberg 1, I L Hansteen 1, O Jelmert 1, A Rønneberg 1
PMCID: PMC1009870  PMID: 2590644

Abstract

Cytogenetic and haematological parameters were studied in 31 oil exposed workers and 31 office workers matched for age and smoking, all men employed by a Norwegian cable manufacturing company. Information was obtained about tobacco and alcohol consumption, infections, allergies, chronic diseases, use of medicines, and exposure to radiography. A decrease in the absolute lymphocyte counts was observed in the most heavily exposed subgroup (p less than 0.05) but no other significant differences were found between exposed workers and referents. The influence of non-occupational variables on the cytogenetic parameters was studied by stepwise multiple linear regression analysis. The frequency of sister chromatid exchanges appeared to be influenced by smoking history (p less than 0.05) and season of sampling (p less than 0.01) and, if season was excluded, by age (p less than 0.05) and current smoking (p less than 0.05). The number of cells with chromosomal aberrations increased with age (p less than 0.05) and lymphocyte count (p less than 0.05), whereas the frequency of stable rearrangements was negatively correlated with current smoking (p less than 0.01).

Full text

PDF
791

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Evans H. J., Buckton K. E., Hamilton G. E., Carothers A. Radiation-induced chromosome aberrations in nuclear-dockyard workers. Nature. 1979 Feb 15;277(5697):531–534. doi: 10.1038/277531a0. [DOI] [PubMed] [Google Scholar]
  2. Funes-Cravioto F., Zapata-Gayon C., Kolmodin-Hedman B., Lambert B., Lindsten J., Norberg E., Nordenskjöld M., Olin R., Swensson A. Chromosome aberrations and sister-chromatid exchange in workers in chemical laboratories and a rotoprinting factory and in children of women laboratory workers. Lancet. 1977 Aug 13;2(8033):322–325. doi: 10.1016/s0140-6736(77)91485-4. [DOI] [PubMed] [Google Scholar]
  3. Galloway S. M., Berry P. K., Nichols W. W., Wolman S. R., Soper K. A., Stolley P. D., Archer P. Chromosome aberrations in individuals occupationally exposed to ethylene oxide, and in a large control population. Mutat Res. 1986 Apr-May;170(1-2):55–74. doi: 10.1016/0165-1218(86)90082-0. [DOI] [PubMed] [Google Scholar]
  4. Hansteen I. L., Jelmert O., Torgrimsen T., Førsund B. Low human exposure to styrene in relation to chromosome breaks, gaps and sister chromatid exchanges. Hereditas. 1984;100(1):87–91. doi: 10.1111/j.1601-5223.1984.tb00109.x. [DOI] [PubMed] [Google Scholar]
  5. Husgafvel-Pursiainen K., Sorsa M., Järventaus H., Norppa H. Sister-chromatid exchanges in lymphocytes of smokers in an experimental study. Mutat Res. 1984 Nov-Dec;138(2-3):197–203. doi: 10.1016/0165-1218(84)90044-2. [DOI] [PubMed] [Google Scholar]
  6. JOHNSON D. E. Hypoplastic anemia following chronic exposure to kerosene. J Am Med Womens Assoc. 1955 Dec;10(12):421–424. [PubMed] [Google Scholar]
  7. Lambert B., Lindblad A., Nordenskjöld M., Werelius B. Increased frequency of sister chromatid exchanges in cigarette smokers. Hereditas. 1978;88(2):147–149. doi: 10.1111/j.1601-5223.1978.tb01617.x. [DOI] [PubMed] [Google Scholar]
  8. Nau C. A., Neal J., Thornton M. C9-C12 fractions obtained from petroleum distillates. An evaluation of their potential toxicity. Arch Environ Health. 1966 Mar;12(3):382–393. doi: 10.1080/00039896.1966.10664385. [DOI] [PubMed] [Google Scholar]
  9. Rao G. S., Kannan K., Goel S. K., Pandya K. P., Shanker R. Subcutaneous kerosene toxicity in albino rats. Environ Res. 1984 Dec;35(2):516–530. doi: 10.1016/0013-9351(84)90158-0. [DOI] [PubMed] [Google Scholar]
  10. Rønneberg A., Andersen A., Skyberg K. Mortality and incidence of cancer among oil exposed workers in a Norwegian cable manufacturing company. Part 2. Mortality and cancer incidence 1953-84. Br J Ind Med. 1988 Sep;45(9):595–601. doi: 10.1136/oem.45.9.595. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Rønneberg A., Skyberg K. Mortality and incidence of cancer among oil exposed workers in a Norwegian cable manufacturing company. Part I. Exposure conditions 1920-79. Br J Ind Med. 1988 Sep;45(9):589–594. doi: 10.1136/oem.45.9.589. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Sarto F., Cominato I., Pinton A. M., Brovedani P. G., Faccioli C. M., Bianchi V., Levis A. G. Cytogenetic damage in workers exposed to ethylene oxide. Mutat Res. 1984 Nov-Dec;138(2-3):185–195. doi: 10.1016/0165-1218(84)90043-0. [DOI] [PubMed] [Google Scholar]
  13. Sinha A. K., Linscombe V. A., Gollapudi B. B., Jersey G. C., Flake R. E., Park C. N. Cytogenetic variability of lymphocytes from phenotypically normal men: influence of age, smoking, season, and sample storage. J Toxicol Environ Health. 1986;17(4):327–345. doi: 10.1080/15287398609530828. [DOI] [PubMed] [Google Scholar]
  14. Soper K. A., Stolley P. D., Galloway S. M., Smith J. G., Nichols W. W., Wolman S. R. Sister-chromatid exchange (SCE) report on control subjects in a study of occupationally exposed workers. Mutat Res. 1984 Oct;129(1):77–88. doi: 10.1016/0027-5107(84)90126-x. [DOI] [PubMed] [Google Scholar]
  15. Srám R. J., Holá N., Kotesovec F., Novákova A. Cytogenetic analysis of peripheral blood lymphocytes in glass workers occupationally exposed to mineral oils. Mutat Res. 1985 Dec;144(4):277–280. doi: 10.1016/0165-7992(85)90064-8. [DOI] [PubMed] [Google Scholar]
  16. Steenland K., Carrano A., Ratcliffe J., Clapp D., Ashworth L., Meinhardt T. A cytogenetic study of papaya workers exposed to ethylene dibromide. Mutat Res. 1986 Jun;170(3):151–160. doi: 10.1016/0165-1218(86)90029-7. [DOI] [PubMed] [Google Scholar]
  17. Van Sittert N. J., de Jong G., Clare M. G., Davies R., Dean B. J., Wren L. J., Wright A. S. Cytogenetic, immunological, and haematological effects in workers in an ethylene oxide manufacturing plant. Br J Ind Med. 1985 Jan;42(1):19–26. doi: 10.1136/oem.42.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Zhou X. T., Li L. R., Cui M. Y., Yu R. F., Li L., Yan Z. A. Cytogenetic monitoring of petrochemical workers. Mutat Res. 1986 Dec;175(4):237–242. doi: 10.1016/0165-7992(86)90060-6. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Industrial Medicine are provided here courtesy of BMJ Publishing Group

RESOURCES